Dopamine neurons encode trial-by-trial subjective reward value in an auction-like task

Autor: Daniel F. Hill, Robert W. Hickman, Alaa Al-Mohammad, Arkadiusz Stasiak, Wolfram Schultz

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)

Abstract The dopamine reward prediction error signal is known to be subjective but has so far only been assessed in aggregate choices. However, personal choices fluctuate across trials and thus reflect the instantaneous subjective reward value. In th

Externí odkaz: https://doaj.org/article/2f933654d24d421891ce47ce75de96c5

Dentate gyrus granule cells are a locus of pathology in Scn8a developmental encephalopathy

Autor: Wenxi Yu, Sophie F. Hill, Limei Zhu, Yiannos Demetriou, Faith Reger, Joanna Mattis, Miriam H. Meisler

Publikováno v: Neurobiology of Disease, Vol 199, Iss , Pp 106591- (2024)

Gain-of-function mutations in SCN8A cause developmental and epileptic encephalopathy (DEE), a disorder characterized by early-onset refractory seizures, deficits in motor and intellectual functions, and increased risk of sudden unexpected death in ep

Externí odkaz: https://doaj.org/article/189c97fcbc4d4863b31a95564c0f9ff5

Microglial activation induces nitric oxide signalling and alters protein S‐nitrosylation patterns in extracellular vesicles

Autor: Natasha Vassileff, Jereme G. Spiers, Sarah E. Bamford, Rohan G. T. Lowe, Keshava K. Datta, Paul J. Pigram, Andrew F. Hill

Publikováno v: Journal of Extracellular Vesicles, Vol 13, Iss 6, Pp n/a-n/a (2024)

Abstract Neuroinflammation is an underlying feature of neurodegenerative conditions, often appearing early in the aetiology of a disease. Microglial activation, a prominent initiator of neuroinflammation, can be induced through lipopolysaccharide (LP

Externí odkaz: https://doaj.org/article/45a9df57564c449e940ed1bb0ad4a68b

Changing snow water storage in natural snow reservoirs

Autor: C. M. Aragon, D. F. Hill

Publikováno v: Hydrology and Earth System Sciences, Vol 28, Pp 781-800 (2024)

This work introduces a novel snow metric, snow water storage (SwS), defined as the integrated area under the snow water equivalent (SWE) curve (units: length-time, e.g., m d). Unlike other widely used snow metrics that capture snow variables at a sin

Externí odkaz: https://doaj.org/article/a978fd9d6f964758befe1c80ce0a7a3a

Randomised multicentre effectiveness trial of rapid syndromic testing by panel assay in children presenting to European emergency departments with acute respiratory infections—trial protocol for the ADEQUATE Paediatric trial

Autor: Alexander Ross, Andrew Atkinson, Maarten J Postma, Federica Vanoni, Julia A Bielicki, Fernando Antoñanzas, Herman Goossens, Elias Iosifidis, Emmanuel Roilides, Mark Lyttle, Elia Vitale, Malte Kohns Vasconcelos, Florence Allantaz, Claire Hawksworth, Pablo Rojo, Dalia Dawoud, Surbhi Malhotra-Kumar, Silke Peter, Hanna Renk, Marc Bonten, Manuel Gijon, Maggie Nyirenda Nyang’wa, Thea van Asselt, Anthony Hemeson, Cristina Prat Aymerich, Simon van der Pol, Parthena Savvidou, Sophie Vandepitte, Emma Gardiner, Michelle Clements, Yasmine Yau, Giulio Vecchia, Federica D’Ambrosio, Wietske Bouwman, Marjolein van Esschoten, Frank Leus, David de Pooter, Leen Timbermont, Juan Pablo Rodriguez Ruiz, Benjamin Hommel, Marie Tessonneau, Jean-Louis Tissier, Philippe Cleuziat, Pim van Dorst, Paula Rojas, Marino Gonzales, Harry Heijerman, Henri van Werkhoven, Maria Simitsopoulou, Kalliopi Pantzartzi, Kostas Zarras, Argyro Ftergioti, Maria Kitsou, Aristea Karypiadou, Charis Lampada, Konstantina Charisi, Olga Tsiatsiou, Elsa Chorafa, Elisavet Michailidou, Ann-Kathrin Stiegler, Carmen Junk, Kristina Kiesel, Maren Belschner, Maike Seyfried, Kristina Schmauder, Tobias Walter, Dominic Imort, Fabian Behret, Rahel Berger, Leon Pfeiffer, Emanuela Früh, Elena Robinson, Andrea Marten, Claudia Werner, Rosa Calderón, Fátima Machín, Laura Cabello, Andrea Seoane, Sofía Mesa, Lidia Oviedo, Luisa Barón, Irene Hernández, Lisa Capozzi, Louisa Brock, Cecilia Hultin, Louise F Hill, Alessia Severi Conti, Gianluca Gualco

Publikováno v: BMJ Open, Vol 14, Iss 4 (2024)

Introduction Syndromic panel assays, that is, using one test to simultaneously target multiple pathogens with overlapping signs and symptoms, have been integrated into routine paediatric care over the past decade, mainly for more severely ill and hos

Externí odkaz: https://doaj.org/article/d5c0be897b4147ba974e10f2eee0d1ef