Výsledky vyhledávání

Differentiating Total- or Partial-Body Irradiation in Baboons Using mRNA Expression Patterns: A Proof of Concept

Autor: Matthias Port, Julian Haupt, Simone Schüle, Patrick Ostheim, Matthäus Majewski, M. Valente, Michael Abend, F. Herodin, Michel Drouet

Publikováno v: Radiation Research. 194

To better predict clinical outcome after radiation exposure, it is very important to know the absorbed dose and body areas exposed. Previously we found that 22 miRNAs appeared to predict total- and partial-body irradiation (TBI and PBI, respectively)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af7bebbaad6ceae03af4168e90f7c8fd
https://doi.org/10.1667/rade-20-00121.1

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Validating Baboon Ex Vivo and In Vivo Radiation-Related Gene Expression with Corresponding Human Data

Publikováno v: Radiation research. 189(4)

The research for high-throughput diagnostic tests for victims of radio/nuclear incidents remains ongoing. In this context, we have previously identified candidate genes that predict risk of late-occurring hematologic acute radiation syndrome (HARS) i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b72c04028392a5fc4a5e7f1d0d41282
https://pubmed.ncbi.nlm.nih.gov/29373091

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Laboratory intercomparison of the cytokinesis-block micronucleus assay

Publikováno v: Radiat. Res. 180, 120-128 (2013)
RADIATION RESEARCH

The focus of the study is an intercomparison of laboratories' dose-assessment performances using the cytokinesis-block micronucleus (CBMN) assay as a diagnostic triage tool for individual radiation dose assessment. Homogenously X-irradiated (240 kVp,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8e325fcfe50367b7bbb898c60826bd6
https://pubmed.ncbi.nlm.nih.gov/23862731

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Laboratory intercomparison of gene expression assays

Autor: Florigio Lista, B. Terbrueggen, Sylwia Kabacik, Andrew R. Missel, R. Greither, Kai Rothkamm, Frederic Zenhausern, Giovanni Faggioni, Thomas Poyot, Michael Abend, Christina Beinke, Muriel Brengues, Christophe Badie, Viktor Meineke, F. Herodin, André Peinnequin, H. Braselmann, Yoganand Balagurunathan, Nordlinger Bernard

Publikováno v: Radiat. Res. 180, 138-148 (2013)

The possibility of a large-scale acute radiation exposure necessitates the development of new methods that could provide rapid individual dose estimates with high sample throughput. The focus of the study was an intercomparison of laboratories' dose-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d11df14c124cd27a5ef07297b5be19e4
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=27391

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First Generation Gene Expression Signature for Early Prediction of Late Occurring Hematological Acute Radiation Syndrome in Baboons

Autor: Michel Drouet, Matthias Port, Marco Valente, Andreas Lamkowski, Matthäus Majewski, Michael Abend, F. Herodin

Publikováno v: Radiation Research. 186:39

We implemented a two-stage study to predict late occurring hematologic acute radiation syndrome (HARS) in a baboon model based on gene expression changes measured in peripheral blood within the first two days after irradiation. Eighteen baboons were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7da6bed68a4fde11a98d144ddb30aff4
https://doi.org/10.1667/rr14318.1

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GFP-transduced CD34+ and Lin- CD34- hematopoietic stem cells did not adopt a cardiac phenotype in a nonhuman primate model of myocardial infarct

Autor: Françoise Norol, Andre Peinnequin, Fabrice Chretien, Francios M. Lemoine, Claude Baillou, Jean-Paul Vernant, F. Herodin, David Klatzmann, Benoit Delache, Roger LeGrand, Richard Isnard, Didier Nègre, Nicolas Bonnet

Publikováno v: Experimental Hematology
Experimental Hematology, 2007, 35 (4), pp.653-61. ⟨10.1016/j.exphem.2006.12.003⟩
Experimental Hematology, Elsevier, 2007, 35 (4), pp.653-61. ⟨10.1016/j.exphem.2006.12.003⟩

International audience; OBJECTIVE: Studies in mice have reported contradictory results on the contribution of bone marrow cells to myocardial regeneration. This study aims to evaluate their ability to differentiate into cells of cardiac lineage in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b8cb1b6e8e31fb2037896743ee31788
https://www.hal.inserm.fr/inserm-00388026/file/Norol-07.pdf

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Cell cycle activation of peripheral blood stem and progenitor cells expanded ex vivo with SCF, FLT-3 ligand, TPO, and IL-3 results in accelerated granulocyte recovery in a baboon model of autologous transplantation but G0/G1 and S/G2/M graft cell content does not correlate with transplantability

Autor: M, Drouet, F, Herodin, F, Norol, F, Mourcin, J F, Mayol

Publikováno v: Stem cells (Dayton, Ohio). 19(5)

Ex vivo expansion is a new strategy for hematopoietic stem and progenitor cell transplantation based on cytokine-induced amplification to produce grafts of controlled maturity. If the cell cycle position of CD34(+) cells has been reported to govern t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::74704b468cd070fa7eee4994393d3a2a
https://pubmed.ncbi.nlm.nih.gov/11553852

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