Zobrazeno 1 - 10
of 2 146
pro vyhledávání: '"F, HUGHES"'
Autor:
Oonagh C. Lyons, Maeve A. Kerr, Mary A. T. Flynn, Leane Hoey, Catherine F. Hughes, Aoife Caffrey, Eamon Laird, Katie Moore, Kirsty M. Porter, Conal Cunningham, Kevin McCarroll, Anne M. Molloy, Fergal Tracey, Maurice O’Kane, J. J. Strain, Mary Ward, Helene McNulty
Publikováno v:
Diabetology & Metabolic Syndrome, Vol 16, Iss 1, Pp 1-18 (2024)
Abstract Background Nutrition is recognized as playing an important role in the metabolic syndrome (MetS), but the dietary components involved are unclear. We aimed to investigate nutrition factors in relation to MetS and its progression in older adu
Externí odkaz:
https://doaj.org/article/ae7632d2ded349deaaea9b75e4b4a165
Autor:
Victoria Ledbetter, Scott Auerbach, Logan J. Everett, Beena Vallanat, Anna Lowit, Gregory Akerman, William Gwinn, Leah C. Wehmas, Michael F. Hughes, Michael Devito, J. Christopher Corton
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
Current methods for cancer risk assessment are resource-intensive and not feasible for most of the thousands of untested chemicals. In earlier studies, we developed a new approach methodology (NAM) to identify liver tumorigens using gene expression b
Externí odkaz:
https://doaj.org/article/b05c465a5b4645b5b3f97f1d7d895f25
Autor:
Helene Damhofer, Tülin Tatar, Benjamin Southgate, Scott Scarneo, Karl Agger, Daria Shlyueva, Lene Uhrbom, Gillian M. Morrison, Philip F. Hughes, Timothy Haystead, Steven M. Pollard, Kristian Helin
Publikováno v:
Cell Death and Disease, Vol 15, Iss 4, Pp 1-17 (2024)
Abstract Poor survival and lack of treatment response in glioblastoma (GBM) is attributed to the persistence of glioma stem cells (GSCs). To identify novel therapeutic approaches, we performed CRISPR/Cas9 knockout screens and discovered TGFβ activat
Externí odkaz:
https://doaj.org/article/9c882069fd714df8a02c424b20d4f84c
Autor:
Peter D. Hibbert, Charlotte J. Molloy, Ian D. Cameron, Leonard C. Gray, Richard L. Reed, Louise K. Wiles, Johanna Westbrook, Gaston Arnolda, Rebecca Bilton, Ruby Ash, Andrew Georgiou, Alison Kitson, Clifford F. Hughes, Susan J. Gordon, Rebecca J. Mitchell, Frances Rapport, Carole Estabrooks, Gregory L. Alexander, Charles Vincent, Adrian Edwards, Andrew Carson-Stevens, Cordula Wagner, Brendan McCormack, Jeffrey Braithwaite
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background This study estimated the prevalence of evidence-based care received by a population-based sample of Australian residents in long-term care (LTC) aged ≥ 65 years in 2021, measured by adherence to clinical practice guideline (CPG)
Externí odkaz:
https://doaj.org/article/08cb650470204549ac984048f4b07f7c
Autor:
Nicola F. Hughes, Lorna A. Fern, Angela Polanco, Chris Carrigan, Richard G. Feltbower, Ashley Gamble, Emily Connearn, Angela Lopez, Ellen Bisci, Kathy Pritchard-Jones
Publikováno v:
Research Involvement and Engagement, Vol 9, Iss 1, Pp 1-10 (2023)
Abstract Background In the United Kingdom, healthcare data is collected on all patients receiving National Health Service (NHS) care, including children and young people (CYP) with cancer. This data is used to inform service delivery, and with specia
Externí odkaz:
https://doaj.org/article/53466b6c26124434bd51a50e0aed3e96
Autor:
Alyssah Ahern, Daniel F. Hughes
Publikováno v:
PeerJ, Vol 12, p e17209 (2024)
Changes to biodiversity from urbanization are occurring worldwide, and baseline data is vital to document the magnitude and direction of these alterations. We set out to document the biodiversity of an urban lake in Eastern Iowa that was devoid of ba
Externí odkaz:
https://doaj.org/article/7c86f5e1838c4579ac95baa04ace3806
Autor:
Adrianna K. San Roman, Helen Skaletsky, Alexander K. Godfrey, Neha V. Bokil, Levi Teitz, Isani Singh, Laura V. Blanton, Daniel W. Bellott, Tatyana Pyntikova, Julian Lange, Natalia Koutseva, Jennifer F. Hughes, Laura Brown, Sidaly Phou, Ashley Buscetta, Paul Kruszka, Nicole Banks, Amalia Dutra, Evgenia Pak, Patricia C. Lasutschinkow, Colleen Keen, Shanlee M. Davis, Angela E. Lin, Nicole R. Tartaglia, Carole Samango-Sprouse, Maximilian Muenke, David C. Page
Publikováno v:
Cell Genomics, Vol 4, Iss 1, Pp 100462- (2024)
Summary: Somatic cells of human males and females have 45 chromosomes in common, including the “active” X chromosome. In males the 46th chromosome is a Y; in females it is an “inactive” X (Xi). Through linear modeling of autosomal gene expres
Externí odkaz:
https://doaj.org/article/f7bcee4c14104a018d0e1ee125035ddd
Autor:
Ricky Nathvani, Sierra N. Clark, Emily Muller, Abosede S. Alli, James E. Bennett, James Nimo, Josephine Bedford Moses, Solomon Baah, A. Barbara Metzler, Michael Brauer, Esra Suel, Allison F. Hughes, Theo Rashid, Emily Gemmell, Simon Moulds, Jill Baumgartner, Mireille Toledano, Ernest Agyemang, George Owusu, Samuel Agyei-Mensah, Raphael E. Arku, Majid Ezzati
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract The urban environment influences human health, safety and wellbeing. Cities in Africa are growing faster than other regions but have limited data to guide urban planning and policies. Our aim was to use smart sensing and analytics to charact
Externí odkaz:
https://doaj.org/article/c87f25fc035e4ae297131f4949aec374
Autor:
Scott A. Scarneo, Aaron P. Smith, Jacob Favret, Robert O’Connell, Joy Pickeral, Kelly W. Yang, Guido Ferrari, David R. Loiselle, Philip F. Hughes, Manjusha M. Kulkarni, Madhusudhana Gargesha, Bryan Scott, Debashish Roy, Barton F. Haynes, Jesse J. Kwiek, Timothy A. J. Haystead
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Heat shock protein 90 (Hsp90) maintains cellular proteostasis during stress and has been under investigation as a therapeutic target in cancer for over two decades. We and others have identified a membrane expressed form of Hsp90 (mHsp90) th
Externí odkaz:
https://doaj.org/article/7498fd35bf0d43599a354d885b957978
Autor:
Jennifer F. Hughes, Helen Skaletsky, Peter K. Nicholls, Alexis Drake, Tatyana Pyntikova, Ting-Jan Cho, Daniel W. Bellott, David C. Page
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-13 (2022)
Abstract Background The mammalian X and Y chromosomes originated from a pair of ordinary autosomes. Over the past ~180 million years, the X and Y have become highly differentiated and now only recombine with each other within a short pseudoautosomal
Externí odkaz:
https://doaj.org/article/36f0d6bd4f974647b276c82792290331