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DÉVELOPPEMENT D'UN MODÈLE ANATOMIQUE ET PHYSIOLOGIQUE RESPIRATOIRE DE PRIMATE NON HUMAIN POUR ÉTUDIER LE DÉPÔT DES AÉROSOLS

Autor: J- R. CREPPY, M. CABRERA, J. PARDESSUS, G. ROSEAU, B. DELACHE, J. MONTHARU, L. GARANGER, F. DUCANCEL, L. VECELLIO

Les études précliniques utilisant des modèles animaux sont essentielles et dans certains cas règlementaires pour les aérosols inhalés. Le macaque a été identifié comme un modèle animal pertinent mais difficile d'accès. Dans le contexte de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eae1851d036b071d7cf77f13e7dade14

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Endothelin-like peptides

Autor: F Ducancel

Publikováno v: Cellular and Molecular Life Sciences. 62:2828-2839

Mammalian endothelins (ETs) and snake venom sarafotoxins (SRTXs) comprise structurally and functionally related potent vasoconstrictor isopeptides that act on the vascular system via identical receptors. This similarity is remarkable, since SRTXs are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7add60987df5bdb7c63f0a060c696af
https://doi.org/10.1007/s00018-005-5286-x

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Precursors of vertebrate peptide antibiotics dermaseptin b and adenoregulin have extensive sequence identities with precursors of opioid peptides dermorphin, dermenkephalin, and deltorphins

Autor: J.-C. Boulain, Mohamed Amiche, A. Menez, F. Ducancel, Amram Mor, Pierre Nicolas

Publikováno v: Journal of Biological Chemistry. 269:17847-17852

The dermaseptins are a family of broad spectrum antimicrobial peptides, 27-34 amino acids long, involved in the defense of the naked skin of frogs against microbial invasion. They are the first vertebrate peptides to show lethal effects against the f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca922a576818e6f7805d3bd232a5ede
https://doi.org/10.1016/s0021-9258(17)32386-4

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Molecular Cloning of a cDNA Encoding the Precursor of Adenoregulin from Frog Skin: Relationships with the Vertebrate Defensive Peptides, Dermaseptins

Autor: J.-C. Boulain, F. Ducancel, E. Lajeunesse, Mohamed Amiche, A. Menez, Pierre Nicolas

Publikováno v: Biochemical and Biophysical Research Communications. 191:983-990

Adenoregulin has recently been isolated from Phyllomedusa skin as a 33 amino acid residues peptide which enhanced binding of agonists to the A1 adenosine receptor. In order to study the structure of the precursor of adenoregulin we constructed a cDNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7635ff75ec9d2dead5bbdee0962fa171
https://doi.org/10.1006/bbrc.1993.1314

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Étude cinétique des propriétés catalytiques de l’hémocyanine de scorpion

Autor: E. Queinnec, Monique Gardès-Albert, M. Goyffon, Christiane Ferradini, Monique Vuillaume, F. Ducancel

Publikováno v: Journal de Chimie Physique. 88:927-935

Les hemocyanines, metalloproteines a cuivre, ont pour fonction de transporter l’oxygene dissous dans l’hemolyniphe de nombreux Mollusques et Arthropodes. Elles presentent egalement des proprietes enzymatiques remarquables : peroxydasiques et cata

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55fce8916c8897979e681a1d20828809
https://doi.org/10.1051/jcp/1991880927

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Highly specific anti-estradiol antibodies: structural characterisation and binding diversity

Autor: C, Monnet, F, Bettsworth, E A, Stura, M H, Le Du, R, Ménez, L, Derrien, S, Zinn-Justin, B, Gilquin, G, Sibaï, N, Battail-Poirot, M, Jolivet, A, Ménez, M, Arnaud, F, Ducancel, J B, Charbonnier

Publikováno v: Journal of molecular biology. 315(4)

Subtle modulation of antibody-binding properties by protein engineering often lies with an accurate structural and energetic description of how an antigen is recognised. Thus, with the intent to increase the affinity and add a bias in favour of natur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b03e5a631f70a575221a124931cb21b3
https://pubmed.ncbi.nlm.nih.gov/11812141

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Stability of a structural scaffold upon activity transfer: X-ray structure of a three fingers chimeric protein

Autor: M H, Le Du, A, Ricciardi, M, Khayati, R, Ménez, J C, Boulain, A, Ménez, F, Ducancel

Publikováno v: Journal of molecular biology. 296(4)

Fasciculin 2 and toxin alpha proteins belong to the same structural family of three-fingered snake toxins. They act on different targets, but in each case the binding region involves residues from loops I and II. The superimposition of the two struct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f3f55f3c15d892b563c6f82a1deaf540
https://pubmed.ncbi.nlm.nih.gov/10686100

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Molecular evolution of snake toxins: is the functional diversity of snake toxins associated with a mechanism of accelerated evolution?

Autor: M, Ohno, R, Ménez, T, Ogawa, J M, Danse, Y, Shimohigashi, C, Fromen, F, Ducancel, S, Zinn-Justin, M H, Le Du, J C, Boulain, T, Tamiya, A, Ménez

Publikováno v: Progress in nucleic acid research and molecular biology. 59

Recent studies revealed that animal toxins with unrelated biological functions often possess a similar architecture. To tentatively understand the evolutionary mechanisms that may govern this principle of functional prodigality associated with a stru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6d658f881dfe5e544440aae0d12c031b
https://pubmed.ncbi.nlm.nih.gov/9427847

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