Zobrazeno 1 - 10
of 325
pro vyhledávání: '"F, Chellat"'
Das natürliche Phänomen der Wirkstoffresistenz stellt eine universelle Beeinträchtigung des Nutzens von pharmazeutischen Wirkstoffen in vielen klinischen Indikationen dar. Antibakterielle und antifungale Wirkstoffe sind dabei ebenso betroffen wie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a39fba416d5771fba1928fa6cb997835
http://hdl.handle.net/11383/2077675
http://hdl.handle.net/11383/2077675
Autor:
Rainer Riedl, Mathieu F. Chellat
Publikováno v:
Angewandte Chemie International Edition. 56:13184-13186
Seek, and ye shall find: After years of focusing research on synthetic antibiotics out of fear that all the useful natural ones had already been found, a novel antibacterial compound has been discovered through conventional microbial extract screenin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5eb83e5b5f265edf331a1834e20c991
https://doi.org/10.1002/anie.201708133
https://doi.org/10.1002/anie.201708133
The natural phenomenon of drug resistance is a widespread issue that hampers the performance of drugs in many major clinical indications. Antibacterial and antifungal drugs are affected, as well as compounds for the treatment of cancer, viral infecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39f68c0309ae6080afcde40e0f342b44
https://hdl.handle.net/11475/21747
https://hdl.handle.net/11475/21747
Autor:
Rainer Riedl, Mathieu F. Chellat
Gesucht und gefunden: Nach Jahren der Fokussierung auf synthetische Antibiotika konnte jetzt ein neuartiger antibiotischer Wirkstoff durch konventionelles Screening in mikrobiellen Naturstoffextrakten entdeckt werden: Pseudouridimycin (PUM). Der sele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a2eafbf6f6e5e5e1c77e85d4635181d
https://hdl.handle.net/11475/2880
https://hdl.handle.net/11475/2880
Publikováno v:
ChemInform. 47
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8df159c338533315498911bbacd2b90e
https://doi.org/10.1002/chin.201629282
https://doi.org/10.1002/chin.201629282
Publikováno v:
Synthesis. 2011:3083-3088
The lithium diisopropylamide mediated halogen dance reaction of 5-iodooxazoles to generate 4-iodooxazoles was studied. The mechanism of the reaction was investigated and compared to the reported mechanism for the halogen dance rearrangement of 5-brom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d8f1fc3e43e0cc6b8319e0f898905e2
https://doi.org/10.1055/s-0030-1260164
https://doi.org/10.1055/s-0030-1260164
Publikováno v:
Organic Letters. 13:3246-3249
The synthesis of all key fragments of the marine macrolide leiodelide A is described. The polyoxygenated northern subunit is derived from d-xylose, while the southern subunit is rapidly assembled via an aldol reaction and Horner-Wadsworth-Emmons olef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f1898dc063ee9b25f7d4065f00114fc
https://doi.org/10.1021/ol201183f
https://doi.org/10.1021/ol201183f
Publikováno v:
ChemInform. 45
Diketones and phenylsulfonylketones can be obtained via the title reaction by using the corresponding enolates which undergo electrophilic trapping by nitroolefins or vinylsulfones.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73acdfc26226251accc90a3069ba9a65
https://doi.org/10.1002/chin.201439034
https://doi.org/10.1002/chin.201439034
Publikováno v:
Organic Letters, Vol. 16, No 7 (2014) pp. 2006-2009
ORGANIC LETTERS
ORGANIC LETTERS
Enantioenriched Al-, Mg-, and Zn-enolates undergo electrophilic trapping by nitroolefins and vinylsulfones to afford 1,4-diketones and 2-(bis(phenylsulfonyl)ethyl)ketones in good yield and excellent diastereoselectivity. A one-pot preparation of inde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bf1de43173f3d7537daeed4faf90c45
https://archive-ouverte.unige.ch/unige:35768
https://archive-ouverte.unige.ch/unige:35768
Autor:
Alexandre Alexakis, Bernardo Pezzati, John C. Stephens, Céline Besnard, Gianna Reginato, John Murphy, Mathieu F. Chellat
Publikováno v:
ChemInform. 44
The title reaction proceeds in the presence of an optically active diphenylprolinol derived catalyst to afford cyclohexadienes with excellent diastereo- and enantioselectivities.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b727343fc31806351e3356982a5eacc2
https://doi.org/10.1002/chin.201346042
https://doi.org/10.1002/chin.201346042