Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IkappaB Kinase 2, TPCA-1 (2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflammatory cytokines and antigen-induced T cell Proliferation.

Autor: L, Podolin Patricia, F, Callahan James, J, Bolognese Brian, H, Li Yue, Karey, Carlson, Gregg, Davis T, W, Mellor Geoff, Christopher, Evans, K, Roshak Amy

Publikováno v: The Journal of Pharmacology and Experimental Therapeutics; January 2005, Vol. 312 Issue: 1 p373-81, 9p