Zobrazeno 1 - 10
of 58
pro vyhledávání: '"F, Breillout"'
Publikováno v:
British Journal of Cancer
A bladder carcinoma cell line (J82) was selected for resistance to the new vinca alkaloid navelbine. The resistance factor of the resistant subline (J82-NVB) to navelbine was 17. P-glycoprotein was not detected in the membrane of J82-NVB cells. The l
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 289(1)
The relevance of chronopharmacology for improving tolerability and antitumor efficacy of the antimitotic drug vinorelbine was investigated in female B6D2F1 mice standardized with 12 h of light and 12 h of darkness. A single i.v. vinorelbine dose (26
Publikováno v:
Anticancer research. 17(2A)
The bladder carcinoma cell line J82-NVB was selected for resistance to the new vinca alkaloid Navelbine. These cells possessed a non-MDR phenotype and were cross-resistant to vinca alkaloids and taxoids. Some morphological differences between sensiti
Publikováno v:
Bulletin du cancer. 81(10)
A phenotype of resistance to the new vinca alkaloid Navelbine was induced in the J82 human bladder carcinoma cells. The resistance factor of the resistant cell line (J82-NVB) to Navelbine was 17. The resistance phenotype of these cells is not a multi
Publikováno v:
Cancer chemotherapy and pharmacology. 32(3)
Using [3H]-vinorelbine, we demonstrated the presence of saturable and time-dependent high-affinity binding sites on human platelets and lymphocytes. The dissociation constant and binding-site values observed were 200 +/- 38 nM, 20.0 +/- 2.2 amol/plat
Autor:
D, Van den Berge, E, Bruyneel, W, Distelmans, S, Van Belle, A, Krikonian, F, Breillout, G, Storme
Publikováno v:
Anticancer research. 13(1)
5'-nor-anhydrovinblastine (Navelbine) is a hemisynthetic Vinca alkaloid for which a selectivity for mitotic microtubules has been demonstrated. In previous studies, we have demonstrated an anti-invasive effect of other Vinca alkaloids. Here the resul
Autor:
C. Bailly, T. Imbert, Nicolas Guilbaud, Jean Philippe Annereau, V. Brel, Jean-Marc Barret, Charles Dumontet, Y. Guminski, F. Breillout
Publikováno v:
Journal of Clinical Oncology. 27:11087-11087
11087 Background: The Polyamine Transport System (PTS) is an energy-dependent machinery generally hyper-active in cancer cells with a high demand for polyamines. This system can be viewed as a suitable molecular gate to deliver selectively polyamine-
Publikováno v:
Cancer research. 51(8)
The pharmacokinetics and metabolism of Navelbine (NVB) were investigated in 20 patients by a specific high performance liquid chromatographic methodology allowing the monitoring of NVB, deacetyl-NVB, and N-oxide NVB. After the i.v. (15 min) administr
Autor:
F Breillout, A Krikorian
Publikováno v:
Onkologie. 14(1)
Vinorelbine (Navelbine) is a new, semisynthetic 5'Nor-vinca-alkaloid, modified on the catharantine ring, developed by Pierre Fabre Medicament. Vinorelbine is a potent as the other vinca alkaloids to inhibit mitotic microtubule polymerization. On the
Publikováno v:
Cancer/Radiothérapie. 2:604