Zobrazeno 1 - 10
of 109
pro vyhledávání: '"F, Benech"'
Autor:
Alexa Patzelt, Christèle Ribaud, Hans Schaefer, Jacques Leclaire, Heike Richter, F. Benech-Kieffer, Gerhard J. Nohynek, Hervé Toutain, Frédérique Hueber-Becker, Wolfram Sterry, Ute Jacobi, Eric K. Dufour, Juergen Lademann
Publikováno v:
Food and Chemical Toxicology. 46:2214-2223
Although in vitro skin absorption studies often detect small residues of applied test material in the epidermis/dermis, it is uncertain whether the residue is within the living skin. We studied the dermal absorption of a hair dye hydroxyanthraquinone
Publikováno v:
Skin Pharmacology and Physiology. 21:89-97
Percutaneous penetration studies are usually performed in human skin samples set up in a Franz® cell device. The ability to perform these studies may depend on the availability of skin samples. Reconstructed skin models are an interesting alternativ
Publikováno v:
Food and Chemical Toxicology. 42:517-543
Hair dyes and their ingredients have moderate to low acute toxicity. Human poisoning accidents are rare and have only been reported following oral ingestion. Contact sensitisation to hair dyes has been a safety issue, mainly as a consequence of unpro
Publikováno v:
Skin Pharmacology and Physiology. 16:343-355
The potential human health risk of UV filters depends on their toxicity and the human systemic exposure which is a function of the extent of percutaneous absorption of the topically applied substance into the human organism. Using a ‘mass balance
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Autor:
Audrey Gueniche, F. Benech, D. Bernard, M. Bayer-Vanmoen, B. Renault, O. Perin, Cécile Clavaud, F. Cabirol, M. Thomas
Publikováno v:
Journal of Investigative Dermatology. 137:S220
Autor:
P. Wegrich, Hans Schaefer, G. Klecak, F. Benech-Kieffer, Jacques Leclaire, R. Schwarzenbach, T. Weber
Publikováno v:
Skin Pharmacology and Physiology. 13:324-335
Appropriate evaluation of sunscreens is required to provide better knowledge of their safety and efficacy. One of the most important elements of this evaluation is the assessment of percutaneous absorption. In vitro methods are largely used for such
Autor:
J Spengler, H Beck, P. Courtellemont, W. Steiling, Walter Diembeck, Marc Paye, Will W. Lovell, F. Benech-Kieffer, J. Dupuis
Publikováno v:
Food and Chemical Toxicology. 37:191-205
The following guidelines present an in vitro alternative, which uses excised animal or human skin, to experiments conducted in vivo on animals or humans for the assessment of dermal absorption and percutaneous penetration. Both aspects are essential
Autor:
P. Boone, S. Hammer, F. Benech-Kieffer, Hidekazu Yamada, F. Yamazaki, A.-C. Goydadin, H. Brocvielle, C. Leclerc, Howard I. Maibach, Monika Schäfer-Korting, T. Yudate, P. Humbert, Jens-Uwe Grundmann, Harald Gollnick, F. Broly, Masaharu Matsukura, Gerhard J. Nohynek, Ulrike Blume-Peytavi, I. Brinkmann, R.G. Ramirez, Hongbo Zhai, Peter Elsner, J.-P. Kantelip, Len Roza, Uta-Christina Hipler, Jacques Leclaire, Ingrid Wiswedel, W.J.A. Meuling, A. Yajima, T. Tezuka, Tobias W. Fischer, U. Münster, Christel C. Müller-Goymann, D. Hirsch, Patrice Muret
Publikováno v:
Skin Pharmacology and Physiology. 16:415-417
Publikováno v:
The British journal of dermatology. 160(1)
Summary Background To date, risk assessment following topical exposure to cosmetic/dermatological formulations cannot be precisely evaluated. Objectives To provide a tool for optimization of active permeation into/through skin and for risk assessment