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ANALYSIS OF TMEFF2 ALLOGRAFTS AND TRANSGENIC MOUSE MODELS REVEALS ROLES IN PROSTATE REGENERATION AND CANCER

Autor: Corbin, JM., Overcash, RF., Wren, JD., Coburn, A., Tipton, GJ., Ezzell, JA., McNaughton, KK., Fung, KM, Kosanke, SD., Ruiz-Echevarria, MJ

Previous results from our lab indicate a tumor suppressor role for the transmembrane protein with epidermal growth factor and two follistatin motifs 2 (TMEFF2) in prostate cancer (PCa). Here, we further characterize this role and uncover new function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7b4a9f61c6fe04a0a52002f5afc87ac3
https://europepmc.org/articles/PMC4722803/

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Akademický článek

Combination of polymeric micelle formulation of TGFβ receptor inhibitors and paclitaxel produces consistent response across different mouse models of Triple-negative breast cancer.

Autor: Vinod N; Division of Pharmacoengineering and Molecular Pharmaceutics, Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy University of North Carolina at Chapel Hill Chapel Hill North Carolina USA.; Joint UNC/NC State Department of Biomedical Engineering University of North Carolina Chapel Hill North Carolina USA.; Present address: National Cancer Institute, National Institutes of Health Bethesda Maryland USA., Hwang D; Division of Pharmacoengineering and Molecular Pharmaceutics, Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy University of North Carolina at Chapel Hill Chapel Hill North Carolina USA.; College of Pharmacy Keimyung University Daegu Republic of Korea., Fussell SC; Department of Biology, Department of Chemistry University of North Carolina at Chapel Hill Chapel Hill North Carolina USA.; Present address: Vaccine Research Center, National Institute of Allergy and Infectious Disease National Institutes of Health Bethesda Maryland USA., Owens TC; Division of Pharmacoengineering and Molecular Pharmaceutics, Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy University of North Carolina at Chapel Hill Chapel Hill North Carolina USA., Tofade OC; Division of Pharmacoengineering and Molecular Pharmaceutics, Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy University of North Carolina at Chapel Hill Chapel Hill North Carolina USA., Benefield TS; Department of Radiology University of North Carolina at Chapel Hill Chapel Hill North Carolina USA., Copling S; Division of Pharmacoengineering and Molecular Pharmaceutics, Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy University of North Carolina at Chapel Hill Chapel Hill North Carolina USA., Ramsey JD; Division of Pharmacoengineering and Molecular Pharmaceutics, Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy University of North Carolina at Chapel Hill Chapel Hill North Carolina USA., Rädler PD; Lineberger Comprehensive Cancer Center University of North Carolina Chapel Hill North Carolina USA.; Department of Genetics University of North Carolina Chapel Hill North Carolina USA., Atkins HM; Lineberger Comprehensive Cancer Center University of North Carolina Chapel Hill North Carolina USA.; Pathology and Laboratory Medicine, School of Medicine University of North Carolina Chapel Hill North Carolina USA.; Department of Pathology and Laboratory Medicine, Division of Comparative Medicine University of North Carolina Chapel Hill North Carolina USA.; Center for Human Health and the Environment North Carolina State University Raleigh North Carolina USA., Livingston EE; Department of Radiology, Biomedical Research Imaging Center, UNC Lineberger Comprehensive Cancer Center University of North Carolina at Chapel Hill Chapel Hill North Carolina USA., Ezzell JA; Histology Research Core University of North Carolina Chapel Hill North Carolina USA., Sokolsky-Papkov M; Division of Pharmacoengineering and Molecular Pharmaceutics, Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy University of North Carolina at Chapel Hill Chapel Hill North Carolina USA., Yuan H; Department of Radiology, Biomedical Research Imaging Center, UNC Lineberger Comprehensive Cancer Center University of North Carolina at Chapel Hill Chapel Hill North Carolina USA., Perou CM; Lineberger Comprehensive Cancer Center University of North Carolina Chapel Hill North Carolina USA.; Department of Genetics University of North Carolina Chapel Hill North Carolina USA., Kabanov AV; Division of Pharmacoengineering and Molecular Pharmaceutics, Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy University of North Carolina at Chapel Hill Chapel Hill North Carolina USA.

Publikováno v: Bioengineering & translational medicine [Bioeng Transl Med] 2024 Jun 04; Vol. 9 (5), pp. e10681. Date of Electronic Publication: 2024 Jun 04 (Print Publication: 2024).

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TDP-43 pathology links innate and adaptive immunity in amyotrophic lateral sclerosis.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jan 10. Date of Electronic Publication: 2024 Jan 10.

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Akademický článek

RNA-binding deficient TDP-43 drives cognitive decline in a mouse model of TDP-43 proteinopathy.

Autor: Necarsulmer JC; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, United States.; Department of Neurology, University of North Carolina, Chapel Hill, United States., Simon JM; UNC Neuroscience Center, University of North Carolina, Chapel Hill, United States.; Carolina Institute for Developmental Disabilities, University of North Carolina, Chapel Hill, United States.; Department of Genetics, University of North Carolina, Chapel Hill, United States., Evangelista BA; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, United States.; Department of Neurology, University of North Carolina, Chapel Hill, United States., Chen Y; Department of Neurology, University of North Carolina, Chapel Hill, United States., Tian X; Department of Neurology, University of North Carolina, Chapel Hill, United States., Nafees S; Department of Neurology, University of North Carolina, Chapel Hill, United States., Marquez AB; Human Pluripotent Stem Cell Core, University of North Carolina, Chapel Hill, United States., Jiang H; Department of Biostatistics, University of North Carolina, Chapel Hill, United States., Wang P; Department of Neurology, University of North Carolina, Chapel Hill, United States., Ajit D; Department of Neurology, University of North Carolina, Chapel Hill, United States., Nikolova VD; Carolina Institute for Developmental Disabilities, University of North Carolina, Chapel Hill, United States.; Department of Psychiatry, The University of North Carolina, Chapel Hill, United States., Harper KM; Carolina Institute for Developmental Disabilities, University of North Carolina, Chapel Hill, United States.; Department of Psychiatry, The University of North Carolina, Chapel Hill, United States., Ezzell JA; Department of Cell Biology & Physiology, Histology Research Core Facility, University of North Carolina, Chapel Hill, United States., Lin FC; Department of Biostatistics, University of North Carolina, Chapel Hill, United States., Beltran AS; Department of Genetics, University of North Carolina, Chapel Hill, United States.; Human Pluripotent Stem Cell Core, University of North Carolina, Chapel Hill, United States.; Department of Pharmacology, University of North Carolina, Chapel Hill, United States., Moy SS; Carolina Institute for Developmental Disabilities, University of North Carolina, Chapel Hill, United States.; Department of Psychiatry, The University of North Carolina, Chapel Hill, United States., Cohen TJ; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, United States.; Department of Neurology, University of North Carolina, Chapel Hill, United States.; UNC Neuroscience Center, University of North Carolina, Chapel Hill, United States.; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, United States.

Publikováno v: ELife [Elife] 2023 Oct 11; Vol. 12. Date of Electronic Publication: 2023 Oct 11.

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Publisher Correction: A postnatal network of co-hepato/pancreatic stem/progenitors in the biliary trees of pigs and humans.

Autor: Zhang W; Department of Cell Biology and Physiology, University of North Carolina (UNC) School of Medicine, Chapel Hill, NC, 27599, USA.; Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University School of Medicine, 200123, Shanghai, China.; Shanghai Engineering Research Center of Stem Cells Translational Medicine, 200335, Shanghai, China.; Shanghai Institute of Stem Cell Research and Clinical Translation, 200120, Shanghai, China., Wang X; Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University School of Medicine, 200123, Shanghai, China.; Shanghai Engineering Research Center of Stem Cells Translational Medicine, 200335, Shanghai, China.; Shanghai Institute of Stem Cell Research and Clinical Translation, 200120, Shanghai, China., Lanzoni G; Diabetes Research Institute, Leonard Miller School of Medicine, 1450 N.W. 10th Avenue, Miami, FL, 33136, USA., Wauthier E; Department of Cell Biology and Physiology, University of North Carolina (UNC) School of Medicine, Chapel Hill, NC, 27599, USA., Simpson S; Department of Molecular Biomedical Sciences, North Carolina State University (NCSU) College of Veterinary Medicine, Raleigh, NC, 27606, USA.; Comparative Medicine Institute, NCSU, Raleigh, NC, 27606, USA., Ezzell JA; Department of Cell Biology and Physiology, University of North Carolina (UNC) School of Medicine, Chapel Hill, NC, 27599, USA., Allen A; Department of Cell Biology and Physiology, University of North Carolina (UNC) School of Medicine, Chapel Hill, NC, 27599, USA., Suitt C; Center for Gastrointestinal Biology and Disease (CGIBD), UNC School of Medicine, Chapel Hill, NC, 27599, USA., Krolik J; Department of Cell Biology and Physiology, University of North Carolina (UNC) School of Medicine, Chapel Hill, NC, 27599, USA., Jhirad A; Department of Cell Biology and Physiology, University of North Carolina (UNC) School of Medicine, Chapel Hill, NC, 27599, USA., Dominguez-Bendala J; Diabetes Research Institute, Leonard Miller School of Medicine, 1450 N.W. 10th Avenue, Miami, FL, 33136, USA., Cardinale V; Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University, Rome, Latina, 04100, Italy., Alvaro D; Department of Translational and Precision Medicine, Sapienza University, Rome, 00185, Italy., Overi D; Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Sapienza University, Rome, 00161, Italy., Gaudio E; Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Sapienza University, Rome, 00161, Italy., Sethupathy P; Department of Biomedical Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY, 14853, USA. pr46@cornell.edu., Carpino G; Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Sapienza University, Rome, 00161, Italy. guido.carpino@uniroma1.it., Adin C; Department of Clinical Sciences, Soft Tissue and Oncologic Surgery Service, College of Veterinary Medicine, NCSU, Raleigh, NC, 27606, USA. adinc@ufl.edu.; Department of Small Animal Clinical Sciences, University of Florida College of Veterinary Medicine, Gainesville, FL, 32608, USA. adinc@ufl.edu., Piedrahita JA; Department of Molecular Biomedical Sciences, North Carolina State University (NCSU) College of Veterinary Medicine, Raleigh, NC, 27606, USA. japiedra@ncsu.edu.; Comparative Medicine Institute, NCSU, Raleigh, NC, 27606, USA. japiedra@ncsu.edu., Mathews K; Department of Clinical Sciences, Soft Tissue and Oncologic Surgery Service, College of Veterinary Medicine, NCSU, Raleigh, NC, 27606, USA. kmathews@ncsu.edu., He Z; Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University School of Medicine, 200123, Shanghai, China. zyhe@tongji.edu.cn.; Shanghai Engineering Research Center of Stem Cells Translational Medicine, 200335, Shanghai, China. zyhe@tongji.edu.cn.; Shanghai Institute of Stem Cell Research and Clinical Translation, 200120, Shanghai, China. zyhe@tongji.edu.cn., Reid LM; Department of Cell Biology and Physiology, University of North Carolina (UNC) School of Medicine, Chapel Hill, NC, 27599, USA. Lola.M.Reid@gmail.com.; Program in Molecular Biology and Biotechnology, UNC School of Medicine, Chapel Hill, NC, 27599, USA. Lola.M.Reid@gmail.com.

Publikováno v: NPJ Regenerative medicine [NPJ Regen Med] 2023 Sep 06; Vol. 8 (1), pp. 47. Date of Electronic Publication: 2023 Sep 06.

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Akademický článek

Intermediate filament dysregulation in astrocytes in the human disease model of KLHL16 mutation in giant axonal neuropathy (GAN).

Autor: Battaglia R; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill., Faridounnia M; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill., Beltran A; Department of Genetics, University of North Carolina at Chapel Hill., Robinson J; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill., Kinghorn K; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill., Ezzell JA; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill., Bharucha-Goebel D; National Institute of Neurological Diseases and Stroke, Bethesda, MD., Bonnemann C; National Institute of Neurological Diseases and Stroke, Bethesda, MD., Hooper JE; Department of Pathology, Stanford University, Palo Alto, CA., Opal P; Departments of Neurology and Cell and Developmental Biology, Northwestern University, Chicago, IL., Bouldin TW; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill., Armao D; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill.; Department of Radiology, University of North Carolina at Chapel Hill., Snider N; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill.

Publikováno v: Molecular biology of the cell [Mol Biol Cell] 2023 Sep 06, pp. mbcE23030094. Date of Electronic Publication: 2023 Sep 06.

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Akademický článek

A postnatal network of co-hepato/pancreatic stem/progenitors in the biliary trees of pigs and humans.

Publikováno v: NPJ Regenerative medicine [NPJ Regen Med] 2023 Aug 01; Vol. 8 (1), pp. 40. Date of Electronic Publication: 2023 Aug 01.

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Combination of Polymeric Micelle Formulation of TGFβ Receptor Inhibitors and Paclitaxel Produce Consistent Response Across Different Mouse Models of TNBC.

Autor: Vinod N; Center for Nanotechnology in Drug Delivery and Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC 27599, United States.; Joint UNC/NC State Department of Biomedical Engineering, University of North Carolina, Chapel Hill, NC 27599, United States., Hwang D; Center for Nanotechnology in Drug Delivery and Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC 27599, United States., Fussell SC; Department of Biology, Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA., Owens TC; Center for Nanotechnology in Drug Delivery and Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC 27599, United States., Tofade OC; Center for Nanotechnology in Drug Delivery and Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC 27599, United States., Copling S; Center for Nanotechnology in Drug Delivery and Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC 27599, United States., Ramsey JD; Center for Nanotechnology in Drug Delivery and Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC 27599, United States., Rädler PD; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, United States.; Department of Genetics, University of North Carolina, Chapel Hill, NC 27514, United States., Atkins HM; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, United States.; Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, United States.; Department of Pathology and Laboratory Medicine, Division of Comparative Medicine, University of North Carolina, Chapel Hill, NC, 27599, USA.; Center for Human Health and the Environment, North Carolina State University, Raleigh, NC, 27695, USA., Livingston EE; Biomedical Research Imaging Center, Department of Radiology, and UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States., Ezzell JA; Histology Research Core, University of North Carolina, Chapel Hill, NC 27599, United States., Sokolsky-Papkov M; Center for Nanotechnology in Drug Delivery and Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC 27599, United States., Yuan H; Biomedical Research Imaging Center, Department of Radiology, and UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States., Perou CM; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, United States.; Department of Genetics, University of North Carolina, Chapel Hill, NC 27514, United States., Kabanov AV; Center for Nanotechnology in Drug Delivery and Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC 27599, United States.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jun 14. Date of Electronic Publication: 2023 Jun 14.

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Akademický článek

Increased tryptophan, but not increased glucose metabolism, predict resistance of pembrolizumab in stage III/IV melanoma.

Autor: Oldan JD; Departments of Radiology, The University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA.; Biomedical Research Imaging Center, UNC-CH,Chapel Hill, NC, USA., Giglio BC; Biomedical Research Imaging Center, UNC-CH,Chapel Hill, NC, USA., Smith E; Departments of Radiology, The University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA.; Biomedical Research Imaging Center, UNC-CH,Chapel Hill, NC, USA., Zhao W; Biomedical Research Imaging Center, UNC-CH,Chapel Hill, NC, USA., Bouchard DM; Lineberger Comprehensive Cancer Center, UNC-CH, Chapel Hill, NC, USA., Ivanovic M; Departments of Radiology, The University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA.; Biomedical Research Imaging Center, UNC-CH,Chapel Hill, NC, USA., Lee YZ; Departments of Radiology, The University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA.; Biomedical Research Imaging Center, UNC-CH,Chapel Hill, NC, USA., Collichio FA; Lineberger Comprehensive Cancer Center, UNC-CH, Chapel Hill, NC, USA.; Departments of Medicine, The University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA., Meyers MO; Lineberger Comprehensive Cancer Center, UNC-CH, Chapel Hill, NC, USA.; Departmant of Surgery, The University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA., Wallack DE; Lineberger Comprehensive Cancer Center, UNC-CH, Chapel Hill, NC, USA., Abernethy-Leinwand A; Biomedical Research Imaging Center, UNC-CH,Chapel Hill, NC, USA., Long PK; Lineberger Comprehensive Cancer Center, UNC-CH, Chapel Hill, NC, USA.; Departmant of Surgery, The University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA., Trembath DG; Departments of Pathology And Laboratory Medicine, The University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA., Googe PB; Departments of Dermatology, The University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA., Kowalski MH; Department of Biostatistics, The University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USA., Ivanova A; Department of Biostatistics, The University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USA., Ezzell JA; Departments of Cell Biology and Physiology, The University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA., Nikolaishvili-Feinberg N; Lineberger Comprehensive Cancer Center, UNC-CH, Chapel Hill, NC, USA., Thomas NE; Lineberger Comprehensive Cancer Center, UNC-CH, Chapel Hill, NC, USA.; Departments of Dermatology, The University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA., Wong TZ; Departments of Radiology, The University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA.; Biomedical Research Imaging Center, UNC-CH,Chapel Hill, NC, USA., Ollila DW; Lineberger Comprehensive Cancer Center, UNC-CH, Chapel Hill, NC, USA.; Departmant of Surgery, The University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA., Li Z; Departments of Radiology, The University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA.; Biomedical Research Imaging Center, UNC-CH,Chapel Hill, NC, USA., Moschos SJ; Lineberger Comprehensive Cancer Center, UNC-CH, Chapel Hill, NC, USA.; Departments of Medicine, The University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC, USA.

Publikováno v: Oncoimmunology [Oncoimmunology] 2023 Apr 26; Vol. 12 (1), pp. 2204753. Date of Electronic Publication: 2023 Apr 26 (Print Publication: 2023).

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Intermediate filament dysregulation and astrocytopathy in the human disease model of KLHL16 mutation in giant axonal neuropathy (GAN).

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Mar 14. Date of Electronic Publication: 2023 Mar 14.

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