Ligand-based design and synthesis of N' -Benzylidene-3,4-dimethoxybenzohydrazide derivatives as potential antimicrobial agents; evaluation by in vitro , in vivo, and in silico approaches with SAR studies.

Autor: Ezz Eldin RR; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Port Said University, Port Said, Egypt., Saleh MA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt., Alotaibi MH; National Center for Chemical Technologies, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia., Alsuair RK; National Center for Chemical Technologies, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia., Alzahrani YA; National Center for Chemical Technologies, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia., Alshehri FA; National Center for Chemical Technologies, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia., Mohamed AF; Department of Anatomy and Embryology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., Hafez SM; Department of Anatomy and Embryology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., Althoqapy AA; Department of Microbiology and Immunology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., Khirala SK; Department of Microbiology and Immunology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., Amin MM; Department of Pharmacology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., A F Y; Department of Physiology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., AbdElwahab AH; Department of Physiology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., Alesawy MS; Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt., Elmaaty AA; Department of Medicinal Chemistry, Faculty of Pharmacy, Port Said University, Port Said, Egypt., Al-Karmalawy AA; Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Horus University-Egypt, New Damietta, Egypt.

Publikováno v: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 1098-1119.

Structure based design and synthesis of 3-(7-nitro-3-oxo-3,4-dihydroquinoxalin-2-yl)propanehydrazide derivatives as novel bacterial DNA-gyrase inhibitors: In-vitro, In-vivo, In-silico and SAR studies.

Autor: Saleh MA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt., Elmaaty AA; Medicinal Chemistry Department, Faculty of Pharmacy, Port Said University, Port Said 42526, Egypt. Electronic address: ayman.mohamed@pharm.psu.edu.eg., El Saeed HS; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt., Saleh MM; Microbiology and Immunology Department, Faculty of Pharmacy, Port Said University, Egypt., Salah M; Microbiology and Immunology Department, Faculty of Pharmacy, Port Said University, Egypt., Ezz Eldin RR; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Port Said University, Port Said, Egypt. Electronic address: rogyezz29@gmail.com.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2022 Dec; Vol. 129, pp. 106186. Date of Electronic Publication: 2022 Oct 05.

Pharmacophore-linked pyrazolo[3,4-d]pyrimidines as EGFR-TK inhibitors: Synthesis, anticancer evaluation, pharmacokinetics, and in silico mechanistic studies.

Autor: Gaber AA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Nasr City, Egypt., El-Morsy AM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Nasr City, Egypt.; Pharmaceutical Chemistry Department, College of Pharmacy, The Islamic University, Najaf, Iraq., Sherbiny FF; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Nasr City, Egypt.; Department of Chemistry, Basic Science Center and Pharmaceutical Organic Chemistry College of Pharmaceutical Science & Drug Manufacturing, Misr University for Science and Technology (MUST), Al-Motamayez District, 6th of October City, Egypt., Bayoumi AH; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Nasr City, Egypt., El-Gamal KM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Nasr City, Egypt., El-Adl K; Department of Medicinal Chemistry & Drug Design, Faculty of Pharmacy, Al-Azhar University, Cairo, Nasr City, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Heliopolis University for Sustainable Development, Cairo, Egypt., Al-Karmalawy AA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Horus University-Egypt, New Damietta, Egypt., Ezz Eldin RR; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Port Said University, Port Said, Egypt., Saleh MA; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt., Abulkhair HS; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Nasr City, Egypt.; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Horus University-Egypt, New Damietta, Egypt.

Publikováno v: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2021 Aug 31, pp. e2100258. Date of Electronic Publication: 2021 Aug 31.