Structure based design and synthesis of 3-(7-nitro-3-oxo-3,4-dihydroquinoxalin-2-yl)propanehydrazide derivatives as novel bacterial DNA-gyrase inhibitors: In-vitro, In-vivo, In-silico and SAR studies

Autor: Saleh, Marwa A., Elmaaty, Ayman Abo, El Saeed, Hoda S., Saleh, Moustafa M., Salah, Mohammed, Ezz Eldin, Rogy R.

Publikováno v: In Bioorganic Chemistry December 2022 129

In vivo screening and toxicity studies of indolinone incorporated thiosemicarbazone, thiazole and piperidinosulfonyl moieties as anticonvulsant agents

Autor: Fayed, Eman A., Ragab, Ahmed, Ezz Eldin, Rogy R., Bayoumi, Ashraf H., Ammar, Yousry A.

Publikováno v: In Bioorganic Chemistry November 2021 116

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Ligand-based design and synthesis of N' -Benzylidene-3,4-dimethoxybenzohydrazide derivatives as potential antimicrobial agents; evaluation by in vitro , in vivo, and in silico approaches with SAR studies.

Autor: Ezz Eldin RR; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Port Said University, Port Said, Egypt., Saleh MA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt., Alotaibi MH; National Center for Chemical Technologies, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia., Alsuair RK; National Center for Chemical Technologies, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia., Alzahrani YA; National Center for Chemical Technologies, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia., Alshehri FA; National Center for Chemical Technologies, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia., Mohamed AF; Department of Anatomy and Embryology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., Hafez SM; Department of Anatomy and Embryology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., Althoqapy AA; Department of Microbiology and Immunology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., Khirala SK; Department of Microbiology and Immunology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., Amin MM; Department of Pharmacology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., A F Y; Department of Physiology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., AbdElwahab AH; Department of Physiology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., Alesawy MS; Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt., Elmaaty AA; Department of Medicinal Chemistry, Faculty of Pharmacy, Port Said University, Port Said, Egypt., Al-Karmalawy AA; Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Horus University-Egypt, New Damietta, Egypt.

Publikováno v: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 1098-1119.