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Akademický článek

Preliminary evidence that lectins in infant soy formula apparently bind bovine milk exosomes and prevent their absorption in healthy adults

Autor: Ezra Mutai, Alice Kah Hui Ngu, Janos Zempleni

Publikováno v: BMC Nutrition, Vol 8, Iss 1, Pp 1-6 (2022)

Abstract Background Milk exosomes and their microRNA (miR) cargos are bioavailable. The content of exosomes and miRs is negligible in infant formulas compared to human milk, and dietary depletion of exosomes led to changes in bacterial communities an

Externí odkaz: https://doaj.org/article/8233c02bf30f4ab4a3ca8b9bfb76f029

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Akademický článek

Small Extracellular Vesicles in Milk Cross the Blood-Brain Barrier in Murine Cerebral Cortex Endothelial Cells and Promote Dendritic Complexity in the Hippocampus and Brain Function in C57BL/6J Mice

Autor: Fang Zhou, Pearl Ebea, Ezra Mutai, Haichuan Wang, Sonal Sukreet, Shya Navazesh, Haluk Dogan, Wenhao Li, Juan Cui, Peng Ji, Denise M. O. Ramirez, Janos Zempleni

Publikováno v: Frontiers in Nutrition, Vol 9 (2022)

Human milk contains large amounts of small extracellular vesicles (sEVs) and their microRNA cargos, whereas infant formulas contain only trace amounts of sEVs and microRNAs. We assessed the transport of sEVs across the blood-brain barrier (BBB) and s

Externí odkaz: https://doaj.org/article/d8c92f9393424d439c15b02cb2a19285

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Akademický článek

Milk exosomes are bioavailable and distinct microRNA cargos have unique tissue distribution patterns

Autor: Sonia Manca, Bijaya Upadhyaya, Ezra Mutai, Amy T. Desaulniers, Rebecca A. Cederberg, Brett R. White, Janos Zempleni

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)

Abstract Exosomes participate in cell-to-cell communication, facilitated by the transfer of RNAs, proteins and lipids from donor to recipient cells. Exosomes and their RNA cargos do not exclusively originate from endogenous synthesis but may also be

Externí odkaz: https://doaj.org/article/d1aac8aef5bf4e3f9c8e1dd99276ab17

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Evaluation and Implementation of Lifestyle Habits and Life's Simple 7 in Northwest Indiana

Autor: Grant Thivierge, Matthew Ladwig, Ezra Mutai, Reagan Bishop, John Durocher

Publikováno v: Physiology. 38

The CDC’s Social Vulnerability Index (SVI) provides insight into many factors that contribute to the lack of health equity, such as poverty, lack of transportation, and crowded housing. Purdue University Northwest (PNW) has campuses located in Hamm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4b8ffd8b6123d6cc0e5e8c2f8135c1e4
https://doi.org/10.1152/physiol.2023.38.s1.5795484

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Milk Exosomes Cross the Blood-Brain Barrier in Murine Cerebral Cortex Endothelial Cells and Promote Dendritic Complexity in the Hippocampus and Brain Function in C57BL/6J Mice

Autor: Janos Zempleni, Peng Ji, Haluk Dogan, Wenhao Li, Ezra Mutai, Fang Zhou, Sonal Sukreet, Juan Cui, Pearl Ebea, Shya Navazesh, Denise M.O. Ramirez

BackgroundHuman milk contains large amounts of exosomes (MEs) and their regulatory microRNA cargos, whereas infant formulas contain only trace amounts of MEs and microRNAs. Breastfeeding has been implicated in optimal brain development but experiment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::acec3a977a4ba4a3578034cad6e33f79
https://doi.org/10.1101/2021.11.24.469889

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Milk-Derived Exosomes and Metabolic Regulation

Autor: Sonal Sukreet, Janos Zempleni, Di Wu, Fang Zhou, Ezra Mutai

Publikováno v: Annual Review of Animal Biosciences. 7:245-262

Exosomes are natural nanoparticles that play an important role in cell-to-cell communication. Communication is achieved through the transfer of cargos, such as microRNAs, from donor to recipient cells and binding of exosomes to cell surface receptors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::628958bfd981df0cadac904edf2ee70b
https://doi.org/10.1146/annurev-animal-020518-115300

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MicroRNAs in bovine milk exosomes are bioavailable in humans but do not elicit a robust pro-inflammatory cytokine response

Autor: Amanda E. Ramer-Tait, Ezra Mutai, Janos Zempleni

Publikováno v: ExRNA, Vol 2, Iss 1, Pp 1-9 (2020)

Background Bovine milk exosomes are studied for their roles as bioactive food compounds and as vehicles for drug delivery. Both lines of investigation converge on immune function, e.g., immune regulation by absorption of microRNAs encapsulated in mil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7465d6fe16722f41888b0258c4694dc3
https://doi.org/10.1186/s41544-019-0041-x

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