Výsledky vyhledávání - "Ezra J. van der Wel"

Atherosclerosis regression is associated with both infiltration of new leukocytes into the plaque and a shift in macrophage polarization towards a more migratory phenotype

Autor: Menno Hoekstra, Ezra J. van der Wel, Miranda Van Eck

Publikováno v: Atherosclerosis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61ce1e58b5f5f694a8b1ebaa6474e748
https://doi.org/10.1016/j.atherosclerosis.2022.06.1013

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Apolipoprotein A1 deficiency in mice primes bone marrow stem cells for T cell lymphopoiesis

Autor: Ezra J. van der Wel, Myrthe E. Reiche, Olga S.C. Snip, Robbert Wever, Miranda Van Eck, Menno Hoekstra, Amber B. Ouweneel, Esther Lutgens, Soňa Kauerova, Frank H. Schaftenaar

Publikováno v: Journal of cell science, 135(5):jcs25890. Company of Biologists Ltd
Journal of Cell Science, 135(5)
Journal of Cell Science
article-version (VoR) Version of Record
Journal of Cell Science, 135(5):jcs.258901. COMPANY BIOLOGISTS LTD

The bone marrow has emerged as a potentially important target in cardiovascular disease as it generates all leukocytes involved in atherogenesis. In the current study, we evaluated whether a change in bone marrow functionality underlies the increased

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab2748ff7a0efa0b00583bd871b00b06
https://hdl.handle.net/1887/3505572

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Hypocholesterolemic phospholipid transfer protein knockout mice exhibit a normal glucocorticoid response to food deprivation

Autor: Menno, Hoekstra, Qiuyu, Liu, Yiheng, Zhang, Ezra J, van der Wel, Sylvia E, Le Dévédec, Miranda, Van Eck

Publikováno v: Am J Transl Res

Objectives: Glucocorticoids, adrenal-derived steroid hormones, facilitate the physiological response to stress. High-density lipoproteins (HDL) are considered the primary source of cholesterol used for glucocorticoid synthesis in mice. Phospholipid t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b1751bf6126ed884d782410696e498aa
https://pubmed.ncbi.nlm.nih.gov/35422905

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PRMT4 inhibitor TP-064 inhibits the pro-inflammatory macrophage lipopolysaccharide response in vitro and ex vivo and induces peritonitis-associated neutrophilia in vivo

Autor: Ezra J. van der Wel, Menno Hoekstra, Miranda Van Eck, Yiheng Zhang, Miriam de Boer

Publikováno v: Biochimica et Biophysica Acta: Molecular Basis of Disease, 1867(11)

Previous in vitro studies have shown that protein arginine N-methyltransferase 4 (PRMT4) is a co-activator for an array of cellular activities, including NF-κB-regulated pro-inflammatory responses. Here we investigated the effect of PRMT4 inhibitor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::014fcc7f95a4daeef364583f753ee6a8
https://doi.org/10.1016/j.bbadis.2021.166212

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Hypercholesterolemia impairs megakaryopoiesis and platelet production in scavenger receptor BI knockout mice

Autor: Ezra J. van der Wel, Menno Hoekstra, Jasmin Hassan, Olga S.C. Snip, Miranda Van Eck, Suzanne J.A. Korporaal, Amber B. Ouweneel, Frank H. Schaftenaar

Publikováno v: Atherosclerosis, 282, 176. Elsevier

Background and aims: Thrombocytopenia in scavenger receptor BI (SR-BI) knockout mice is suggested to result from augmented platelet clearance induced by elevated intracellular unesterified cholesterol (UC) levels. We hypothesize that SR-BI deficiency

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c5f5cc43d3a5ebe8da8472c2f38927a
https://hdl.handle.net/1887/3203171

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