Zobrazeno 1 - 10
of 533
pro vyhledávání: '"Ezra E.W. Cohen"'
Human papillomavirus E5 suppresses immunity via inhibition of the immunoproteasome and STING pathway
Autor:
Sayuri Miyauchi, Sangwoo S. Kim, Riley N. Jones, Lin Zhang, Kripa Guram, Sonia Sharma, Stephen P. Schoenberger, Ezra E.W. Cohen, Joseph A. Califano, Andrew B. Sharabi
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112508- (2023)
Summary: The role that human papillomavirus (HPV) oncogenes play in suppressing responses to immunotherapy in cancer deserves further investigation. In particular, the effects of HPV E5 remain poorly understood relative to E6 and E7. Here, we demonst
Externí odkaz:
https://doaj.org/article/0ab3a92f30554844b0725683d435e893
Autor:
Spencer E. Brightman, Martin S. Naradikian, Rukman R. Thota, Angelica Becker, Leslie Montero, Milad Bahmanof, Ashmitaa Logandha Ramamoorthy Premlal, Jason A. Greenbaum, Bjoern Peters, Ezra E.W. Cohen, Aaron M. Miller, Stephen P. Schoenberger
Publikováno v:
JCI Insight, Vol 8, Iss 2 (2023)
CD4+ T cells play a critical role in antitumor immunity via recognition of peptide antigens presented on MHC class II (MHC-II). Although some solid cancers can be induced to express MHC-II, the extent to which this enables direct recognition by tumor
Externí odkaz:
https://doaj.org/article/269a1b54d04f495aa248feef28743e01
Autor:
J. Silvio Gutkind, Alfredo A. Molinolo, Xingyu Wu, Zhiyong Wang, Daniela Nachmanson, Olivier Harismendy, Ludmil B. Alexandrov, Beverly R. Wuertz, Frank G. Ondrey, Denise Laronde, Leigha D. Rock, Miriam Rosin, Charles Coffey, Valerie D. Butler, Lisa Bengtson, Chiu-Hsieh Hsu, Julie E. Bauman, Stephen M. Hewitt, Ezra E.W. Cohen, H-H. Sherry Chow, Scott M. Lippman, Eva Szabo
Publikováno v:
JCI Insight, Vol 6, Iss 17 (2021)
BACKGROUND The aberrant activation of the PI3K/mTOR signaling circuitry is one of the most frequently dysregulated signaling events in head and neck squamous cell carcinoma (HNSCC). Here, we conducted a single-arm, open-label phase IIa clinical trial
Externí odkaz:
https://doaj.org/article/7bd72c5d13414014a05eecb53dce3ebd
Autor:
David S. Hong, Michael Postow, Bartosz Chmielowski, Ryan Sullivan, Amita Patnaik, Ezra E.W. Cohen, Geoffrey Shapiro, Conor Steuer, Martin Gutierrez, Heather Yeckes-Rodin, Robert Ilaria, Brenda O'Connell, Joanna Peng, Guangbin Peng, Nora Zizlsperger, Anthony Tolcher, Jedd D. Wolchok
Publikováno v:
Clinical Cancer Research. :OF1-OF10
Purpose: Eganelisib (IPI-549) is a first-in-class, orally administered, highly selective PI3Kγ inhibitor with antitumor activity alone and in combination with programmed cell death protein 1/ligand 1 (PD-1/PD-L1) inhibitors in preclinical studies. T
Autor:
Joseph S. Dolina, Joey Lee, Spencer E. Brightman, Sara McArdle, Samantha M. Hall, Rukman R. Thota, Manasa Lanka, Ashmitaa Logandha Ramamoorthy Premlal, Jason A. Greenbaum, Ezra E.W. Cohen, Bjoern Peters, Stephen P. Schoenberger
Publikováno v:
bioRxiv
Therapeutic benefit to immune checkpoint blockade (ICB) is currently limited to the subset of cancers thought to possess a sufficient tumor mutational burden (TMB) to allow for the spontaneous recognition of neoantigens (NeoAg) by autologous T cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::458ca4cdb3519a9775be1f21081abf43
https://europepmc.org/articles/PMC10187312/
https://europepmc.org/articles/PMC10187312/
Autor:
Ari J. Rosenberg, Chih-Yi Liao, Theodore Karrison, Jonas A. de Souza, Francis P. Worden, Bernadette Libao, Monika K. Krzyzanowska, D. Neil Hayes, Eric Winquist, Vassiliki Saloura, Kevin Prescott, Victoria M. Villaflor, Tanguy Y. Seiwert, Rebecca B. Schechter, Walter M. Stadler, Ezra E.W. Cohen, Everett E. Vokes
Publikováno v:
Annals of Oncology.
Autor:
Cherie-Ann O. Nathan, D. Neil Hayes, Theodore Karrison, Olivier Harismendy, José M. Flores, Tara Moore-Medlin, Everett E. Vokes, J. Silvio Gutkind, Prakash Neupane, Glenn Mills, Zoukaa Sargi, Tanguy Seiwert, Juneko Grilley-Olson, Terry Day, Maura Gillison, James L. Wade, Lawrence Feldman, Gautam Jha, Mark Kozloff, Miriam O'Leary, Francis P. Worden, Ezra E.W. Cohen
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 28, iss 23
Clin Cancer Res
Clin Cancer Res
Purpose: Investigate whether adjuvant everolimus, an mTOR inhibitor, improves progression-free survival (PFS) in advanced-stage head and neck squamous cell carcinoma (HNSCC) and provide outcomes related to correlative biological factors associated wi
Autor:
Jedd D. Wolchok, Anthony Tolcher, Nora Zizlsperger, Guangbin Peng, Joanna Peng, Brenda O'Connell, Robert Ilaria, Heather Yeckes-Rodin, Martin Gutierrez, Conor Steuer, Geoffrey Shapiro, Ezra E.W. Cohen, Amita Patnaik, Ryan Sullivan, Bartosz Chmielowski, Michael Postow, David S. Hong
Study IPI-549-01 progression-free survival censoring rules for efficacy analyses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3449dda81899432179d1e7829050dfc0
https://doi.org/10.1158/1078-0432.22700464
https://doi.org/10.1158/1078-0432.22700464
Autor:
Jedd D. Wolchok, Anthony Tolcher, Nora Zizlsperger, Guangbin Peng, Joanna Peng, Brenda O'Connell, Robert Ilaria, Heather Yeckes-Rodin, Martin Gutierrez, Conor Steuer, Geoffrey Shapiro, Ezra E.W. Cohen, Amita Patnaik, Ryan Sullivan, Bartosz Chmielowski, Michael Postow, David S. Hong
Purpose:Eganelisib (IPI-549) is a first-in-class, orally administered, highly selective PI3Kγ inhibitor with antitumor activity alone and in combination with programmed cell death protein 1/ligand 1 (PD-1/PD-L1) inhibitors in preclinical studies. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::746d8eba95c048501f4f9a57f5e24227
https://doi.org/10.1158/1078-0432.c.6618073
https://doi.org/10.1158/1078-0432.c.6618073
Autor:
Jedd D. Wolchok, Anthony Tolcher, Nora Zizlsperger, Guangbin Peng, Joanna Peng, Brenda O'Connell, Robert Ilaria, Heather Yeckes-Rodin, Martin Gutierrez, Conor Steuer, Geoffrey Shapiro, Ezra E.W. Cohen, Amita Patnaik, Ryan Sullivan, Bartosz Chmielowski, Michael Postow, David S. Hong
Study IPI-549-01 full protocol inclusion and exclusion criteria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77fdad17852c392b3f16271b9f9278fa
https://doi.org/10.1158/1078-0432.22700461.v1
https://doi.org/10.1158/1078-0432.22700461.v1