Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Ezra B Ketema"'
1
Akademický článek
High risk of early sub-therapeutic penicillin concentrations after intramuscular benzathine penicillin G injections in Ethiopian children and adults with rheumatic heart disease.
Autor: Ezra B Ketema, Nigus Z Gishen, Abraha Hailu, Abadi Leul, Abera Hadgu, Kiflom Hagos, Samual Berhane, Temesgen Tsega, Madhu Page-Sharp, Timothy Me Davis, Brioni Moore, Kevin T Batty, Jonathan Carapetis, Sam Salman, Laurens Manning
Publikováno v: PLoS Neglected Tropical Diseases, Vol 15, Iss 6, p e0009399 (2021)
IntroductionIntramuscular benzathine penicillin G (BPG) injections are a cornerstone of secondary prophylaxis to prevent acute rheumatic fever (ARF) and rheumatic heart disease (RHD). Uncertainties regarding inter-ethnic and preparation variability,
Externí odkaz: https://doaj.org/article/a8be4e16c1974b01be6d3c664dcb0d1a
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2
Akademický článek
The role of acetylation in obesity-induced cardiac metabolic alterations
Autor: Ezra B. Ketema, Gary D. Lopaschuk
Publikováno v: Journal of Pharmacy & Pharmaceutical Sciences, Vol 27 (2024)
Obesity is a growing public health problem, with its prevalence rate having tripled in the last five decades. It has been shown that obesity is associated with alterations in cardiac energy metabolism, which in turn plays a significant role in heart
Externí odkaz: https://doaj.org/article/62d6643f702c4cbca210aee41909a1db
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3
Akademický článek
Protein lysine acetylation does not contribute to the high rates of fatty acid oxidation seen in the post-ischemic heart
Autor: Ezra B. Ketema, Muhammad Ahsan, Liyan Zhang, Qutuba G. Karwi, Gary D. Lopaschuk
Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract High rates of cardiac fatty acid oxidation during reperfusion of ischemic hearts contribute to contractile dysfunction. This study aimed to investigate whether lysine acetylation affects fatty acid oxidation rates and recovery in post-ischem
Externí odkaz: https://doaj.org/article/45a63400048c4dca9d03e141156144d1
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5
Post-translational Acetylation Control of Cardiac Energy Metabolism
Autor: Ezra B. Ketema, Gary D. Lopaschuk
Publikováno v: Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Frontiers in Cardiovascular Medicine
Perturbations in myocardial energy substrate metabolism are key contributors to the pathogenesis of heart diseases. However, the underlying causes of these metabolic alterations remain poorly understood. Recently, post-translational acetylation-media
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c27a1929020d9b3e060e864575cf557
https://www.frontiersin.org/articles/10.3389/fcvm.2021.723996/full
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6
Metabolic, structural and biochemical changes in diabetes and the development of heart failure
Autor: Kim L, Ho, Qutuba G, Karwi, David, Connolly, Simran, Pherwani, Ezra B, Ketema, John R, Ussher, Gary D, Lopaschuk
Publikováno v: Diabetologia. 65(3)
Diabetes contributes to the development of heart failure through various metabolic, structural and biochemical changes. The presence of diabetes increases the risk for the development of cardiovascular disease (CVD), and since the introduction of car
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::063b9c556c79ffe02682f72613232a2b
https://pubmed.ncbi.nlm.nih.gov/34994805
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7
Concurrent diabetes and heart failure: interplay and novel therapeutic approaches
Autor: Qutuba G. Karwi, Qiu Yu Sun, Kim L. Ho, Simran Pherwani, Ezra B. Ketema, Gary D. Lopaschuk
Publikováno v: Cardiovascular research. 118(3)
Diabetes mellitus increases the risk of developing heart failure, and the co-existence of both diseases worsens cardiovascular outcomes, hospitalization, and the progression of heart failure. Despite current advancements on therapeutic strategies to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65024d5739744cd443bcd9f00323e566
https://pubmed.ncbi.nlm.nih.gov/34897419
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9
Ketone metabolism in the failing heart
Autor: Kim L. Ho, Qutuba G. Karwi, Simran Pherwani, Gary D. Lopaschuk, Ezra B. Ketema
Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1865:158813
The high energy demands of the heart are met primarily by the mitochondrial oxidation of fatty acids and glucose. However, in heart failure there is a decrease in cardiac mitochondrial oxidative metabolism and glucose oxidation that can lead to an en
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97f30219deffb47f3af91ac0b0e6ffe5
https://doi.org/10.1016/j.bbalip.2020.158813
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10
Akademický článek
Apoptotic pathways as a therapeutic target for colorectal cancer treatment.
Autor: Abraha AM; Aman M Abraha, Ezra B Ketema, Department of Medical Biochemistry, College of Health Sciences, Mekelle University, Mekelle 1871, Ethiopia., Ketema EB; Aman M Abraha, Ezra B Ketema, Department of Medical Biochemistry, College of Health Sciences, Mekelle University, Mekelle 1871, Ethiopia.
Publikováno v: World journal of gastrointestinal oncology [World J Gastrointest Oncol] 2016 Aug 15; Vol. 8 (8), pp. 583-91.
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