The novel drug candidate VOMG kills Mycobacterium abscessus and other pathogens by inhibiting cell division.

Autor: Degiacomi G; Department of Biology and Biotechnology 'Lazzaro Spallanzani', University of Pavia, Pavia, Italy., Chiarelli LR; Department of Biology and Biotechnology 'Lazzaro Spallanzani', University of Pavia, Pavia, Italy., Riabova O; Federal Research Centre 'Fundamentals of Biotechnology' of the Russian Academy of Sciences, Moscow, Russia., Loré NI; Emerging Bacterial Pathogens Unit, Division of Immunology, Transplantation and Infectious Disease, IRCCS San Raffaele Scientific Institute, Milan, Italy., Muñoz-Muñoz L; Department of Microbiology/Faculty of Medicine, University of Zaragoza, Zaragoza, Spain., Recchia D; Department of Biology and Biotechnology 'Lazzaro Spallanzani', University of Pavia, Pavia, Italy., Stelitano G; Department of Biology and Biotechnology 'Lazzaro Spallanzani', University of Pavia, Pavia, Italy., Postiglione U; Department of Biology and Biotechnology 'Lazzaro Spallanzani', University of Pavia, Pavia, Italy., Saliu F; Emerging Bacterial Pathogens Unit, Division of Immunology, Transplantation and Infectious Disease, IRCCS San Raffaele Scientific Institute, Milan, Italy., Griego A; Department of Pharmaceutical Sciences, University of Milan, Milan, Italy; National Institute of Molecular Genetics, Milan, Italy., Scoffone VC; Department of Biology and Biotechnology 'Lazzaro Spallanzani', University of Pavia, Pavia, Italy., Kazakova E; Federal Research Centre 'Fundamentals of Biotechnology' of the Russian Academy of Sciences, Moscow, Russia., Scarpa E; Department of Pharmaceutical Sciences, University of Milan, Milan, Italy; National Institute of Molecular Genetics, Milan, Italy., Ezquerra-Aznárez JM; Department of Microbiology/Faculty of Medicine, University of Zaragoza, Zaragoza, Spain., Stamilla A; Department of Biology and Biotechnology 'Lazzaro Spallanzani', University of Pavia, Pavia, Italy., Buroni S; Department of Biology and Biotechnology 'Lazzaro Spallanzani', University of Pavia, Pavia, Italy., Tortoli E; Emerging Bacterial Pathogens Unit, Division of Immunology, Transplantation and Infectious Disease, IRCCS San Raffaele Scientific Institute, Milan, Italy., Rizzello L; Department of Pharmaceutical Sciences, University of Milan, Milan, Italy; National Institute of Molecular Genetics, Milan, Italy., Sassera D; Department of Biology and Biotechnology 'Lazzaro Spallanzani', University of Pavia, Pavia, Italy; Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Ramón-García S; Department of Microbiology/Faculty of Medicine, University of Zaragoza, Zaragoza, Spain; Research and Development Agency of Aragon Foundation, Zaragoza, Spain; Spanish Network for Research on Respiratory Diseases, Carlos III Health Institute, Madrid, Spain. Electronic address: santiramon@unizar.es., Cirillo DM; Emerging Bacterial Pathogens Unit, Division of Immunology, Transplantation and Infectious Disease, IRCCS San Raffaele Scientific Institute, Milan, Italy. Electronic address: cirillo.daniela@hsr.it., Makarov V; Federal Research Centre 'Fundamentals of Biotechnology' of the Russian Academy of Sciences, Moscow, Russia. Electronic address: makarov@inbi.ras.ru., Pasca MR; Department of Biology and Biotechnology 'Lazzaro Spallanzani', University of Pavia, Pavia, Italy; Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. Electronic address: mariarosalia.pasca@unipv.it.

Publikováno v: International journal of antimicrobial agents [Int J Antimicrob Agents] 2024 Oct; Vol. 64 (4), pp. 107278. Date of Electronic Publication: 2024 Jul 26.

Overcoming the Prokaryote/Eukaryote Barrier in Tuberculosis Treatment: A Prospect for the Repurposing and Use of Antiparasitic Drugs.

Autor: Ezquerra-Aznárez JM; Departamento de Microbiología, Facultad de Medicina, Instituto de Biocomputación y Física de Sistemas Complejos (BIFI), Universidad de Zaragoza, 50009 Zaragoza, Spain., Almeida da Silva PE; Departamento de Microbiología, Facultad de Medicina, Instituto de Biocomputación y Física de Sistemas Complejos (BIFI), Universidad de Zaragoza, 50009 Zaragoza, Spain.; Programa de Pós-Graduação em Ciências da Saúde, Faculdade de Medicina, Universidade Federal do Rio Grande, Rio Grande 96200-190, Brazil., Aínsa JA; Departamento de Microbiología, Facultad de Medicina, Instituto de Biocomputación y Física de Sistemas Complejos (BIFI), Universidad de Zaragoza, 50009 Zaragoza, Spain.; Instituto de Investigación Sanitaria de Aragón (IIS-Aragón), 50009 Zaragoza, Spain.; CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, 28029 Madrid, Spain.

Publikováno v: Microorganisms [Microorganisms] 2021 Nov 11; Vol. 9 (11). Date of Electronic Publication: 2021 Nov 11.