Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Ezio T. Fok"'
Autor:
Simone J.C.F.M. Moorlag, Yessica Alina Rodriguez-Rosales, Joshua Gillard, Stephanie Fanucchi, Kate Theunissen, Boris Novakovic, Cynthia M. de Bont, Yutaka Negishi, Ezio T. Fok, Lydia Kalafati, Panayotis Verginis, Vera P. Mourits, Valerie A.C.M. Koeken, L. Charlotte J. de Bree, Ger J.M. Pruijn, Craig Fenwick, Reinout van Crevel, Leo A.B. Joosten, Irma Joosten, Hans Koenen, Musa M. Mhlanga, Dimitri A. Diavatopoulos, Triantafyllos Chavakis, Mihai G. Netea
Publikováno v:
Cell Reports, Vol 33, Iss 7, Pp 108387- (2020)
Summary: The tuberculosis vaccine bacillus Calmette-Guérin (BCG) protects against some heterologous infections, probably via induction of non-specific innate immune memory in monocytes and natural killer (NK) cells, a process known as trained immuni
Externí odkaz:
https://doaj.org/article/867252fa4e9041d0b4262603d849461e
Publikováno v:
Frontiers in Immunology, Vol 9 (2019)
Trained immunity describes the ability of innate immune cells to form immunological memories of prior encounters with pathogens. Recollection of these memories during a secondary encounter manifests a broadly enhanced inflammatory response characteri
Externí odkaz:
https://doaj.org/article/21c64b4163184cc9a71445c32d3a101e
Publikováno v:
South African Journal of Science, Vol 111, Iss 7/8, Pp 7-7 (2015)
Efficient and robust genome editing tools and strategies allow for specific and exact genetic changes to be captured in model systems, thereby accelerating both forward and reverse genetics studies. The development of CRISPR/Cas9 as a facile designer
Externí odkaz:
https://doaj.org/article/8633e968eb97410d9a54fcc4c7c76be2
Autor:
Collins K. Boahen, S.J.C.F.M. Moorlag, Kristoffer Jarlov Jensen, Vasiliki Matzaraki, Stephanie Fanucchi, Ivan Monteiro, Charlotte de Bree, Ezio T. Fok, Musa Mhlanga, Leo A.B. Joosten, Peter Aaby, Christine Stabell Benn, Mihai G. Netea, Vinod Kumar
Publikováno v:
Journal of Genetics and Genomics
Journal of Genetics and Genomics, 50, 434-446
Journal of Genetics and Genomics, 50, 6, pp. 434-446
Journal of Genetics and Genomics, 50, 434-446
Journal of Genetics and Genomics, 50, 6, pp. 434-446
Genetic variation is a key factor influencing cytokine production capacity, but which genetic loci regulate cytokine production before and after vaccination, particularly in African population is unknown. Here, we aimed to identify single-nucleotide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::625d07a3bd9cd39509af3a8027f8a137
https://doi.org/10.1016/j.jgg.2023.01.002
https://doi.org/10.1016/j.jgg.2023.01.002
Autor:
Jéssica C. dos Santos, Zhenhua Zhang, Louise E. van Eekeren, Ezio T. Fok, Nadira Vadaq, Lisa van de Wijer, Wouter A. van der Heijden, Valerie A. C. M. Koeken, Hans J.P.M. Koenen, Musa Mhlanga, Mihai G. Netea, André J. van der Ven, Yang Li
C-C chemokine receptor 5 (CCR5) is the main HIV co-receptor affecting susceptibility and disease course. Quantitative trait loci (QTL) mapping analysis was performed to assess genetic variants associated with CCR5 expression on circulating immune cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e51fac8825d6c7e6077cf5342a18174
https://doi.org/10.1101/2022.06.19.496757
https://doi.org/10.1101/2022.06.19.496757
Genetic regulators of cytokine responses in children from West Africa: the impact of BCG vaccination
Autor:
Collins K. Boahen, S.J.C.F.M. Moorlag, Kristoffer Jarlov Jensen, Vasiliki Matzaraki, Stephanie Fanucchi, Ivan Monteiro, Charlotte de Bree, Ezio T. Fok, Musa Mhlanga, Leo A.B Joosten, Peter Aaby, Christine Stabell Benn, Mihai G. Netea, Vinod Kumar
Genetic variation is a key factor influencing cytokine production capacity, but which genetic loci regulate cytokine production before and after vaccination, particularly in African population is unknown. Here, we aimed to identify single-nucleotide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dba9abb2bca4a47d116c4a7f01eb3312
https://doi.org/10.21203/rs.3.rs-1502935/v1
https://doi.org/10.21203/rs.3.rs-1502935/v1
Autor:
Kathleen Börner, Youtaro Shibayama, Kevin C. Wang, Dirk Grimm, Emiliano Dalla, Stoyan Stoychev, Stephanie Fanucchi, Guoliang Li, Musa M. Mhlanga, Ezio T. Fok, Wing-Kin Sung, Maxim Imakaev, Erin Y. Chang
Publikováno v:
Nature Genetics
Nature Genetics, 2018, 51, pp.138-150. ⟨10.1038/s41588-018-0298-2⟩
Nature Genetics, 2018, 51, pp.138-150. ⟨10.1038/s41588-018-0298-2⟩
Accumulation of trimethylation of histone H3 at lysine 4 (H3K4me3) on immune-related gene promoters underlies robust transcription during trained immunity. However, the molecular basis for this remains unknown. Here we show three-dimensional chromati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9efd61b63585c6308867bb9873452509
https://doi.org/10.1038/s41588-018-0298-2
https://doi.org/10.1038/s41588-018-0298-2
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2157
The organization of the eukaryotic nucleus facilitates functional chromatin contacts which regulate gene transcription. Despite this being extensively studied through population-based chromatin contact mapping and microscopic observations in single c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3188843eeca1f7a40f6e694b94cadc79
https://pubmed.ncbi.nlm.nih.gov/32820405
https://pubmed.ncbi.nlm.nih.gov/32820405
Publikováno v:
Methods in Molecular Biology ISBN: 9781071606636
Bodega, B; Lanzuolo, C (ed.), Capturing Chromosome Conformation, pp. 197-212
Bodega, B; Lanzuolo, C (ed.), Capturing Chromosome Conformation, pp. 197-212
The organization of the eukaryotic nucleus facilitates functional chromatin contacts which regulate gene transcription. Despite this being extensively studied through population-based chromatin contact mapping and microscopic observations in single c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d588db527af2ce6953a4353d9a1e31fb
https://doi.org/10.1007/978-1-0716-0664-3_11
https://doi.org/10.1007/978-1-0716-0664-3_11
Autor:
Ezio T. Fok, Musa M. Mhlanga, Mihai G. Netea, Stephanie Fanucchi, Jorge Domínguez-Andrés, Yutaka Negishi, Leo A. B. Joosten, Cameron M. Green, Simone J.C.F.M. Moorlag
SummaryWe use a data quality model to demonstrate that BCG vaccination is correlated with protection from death from COVID19From a mechanistic perspective, BCG is well described to elicit its protective non-specific effects through the process of tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a0701ee5d83b0a639dc4e589b07fae2
https://doi.org/10.1101/2020.04.10.20060905
https://doi.org/10.1101/2020.04.10.20060905