Association of plasma YKL-40 with brain amyloid-β levels, memory performance, and sex in subjective memory complainers

Autor: Andrea Vergallo, Simone Lista, Pablo Lemercier, Patrizia A. Chiesa, Henrik Zetterberg, Kaj Blennow, Marie-Claude Potier, Marie-Odile Habert, Filippo Baldacci, Enrica Cavedo, Filippo Caraci, Bruno Dubois, Harald Hampel, Hovagim Bakardjian, Habib Benali, Hugo Bertin, Joel Bonheur, Laurie Boukadida, Nadia Boukerrou, Patrizia Chiesa, Olivier Colliot, Marion Dubois, Stéphane Epelbaum, Geoffroy Gagliardi, Remy Genthon, Marion Houot, Aurélie Kas, Foudil Lamari, Marcel Levy, Christiane Metzinger, Fanny Mochel, Francis Nyasse, Catherine Poisson, Marie Revillon, Antonio Santos, Katia Santos Andrade, Marine Sole, Mohmed Surtee, Michel Thiebaut de Schotten, Nadjia Younsi, Mohammad Afshar, Lisi Flores Aguilar, Leyla Akman-Anderson, Joaquín Arenas, Jesús Ávila, Claudio Babiloni, Richard Batrla, Norbert Benda, Keith L. Black, Arun L.W. Bokde, Ubaldo Bonuccelli, Karl Broich, Francesco Cacciola, Giuseppe Caruso, Juan Castrillo†, Roberto Ceravolo, Massimo Corbo, Jean-Christophe Corvol, Augusto Claudio Cuello, Jeffrey L. Cummings, Herman Depypere, Andrea Duggento, Enzo Emanuele, Valentina Escott-Price, Howard Federoff, Maria Teresa Ferretti, Massimo Fiandaca, Richard A. Frank, Francesco Garaci, Hugo Geerts, Ezio Giacobini, Filippo S. Giorgi, Edward J. Goetzl, Manuela Graziani, Marion Haberkamp, Britta Hänisch, Karl Herholz, Felix Hernandez, Bruno P. Imbimbo, Dimitrios Kapogiannis, Eric Karran, Steven J. Kiddle, Seung H. Kim, Yosef Koronyo, Maya Koronyo-Hamaoui, Todd Langevin, Stéphane Lehéricy, Francisco Llavero, Jean Lorenceau, Alejandro Lucía, Dalila Mango, Mark Mapstone, Christian Neri, Robert Nisticò, Sid E. O’bryant, Giovanni Palermo, George Perry, Craig Ritchie, Simone Rossi, Amira Saidi, Emiliano Santarnecchi, Lon S. Schneider, Olaf Sporns, Nicola Toschi, Pedro L. Valenzuela, Bruno Vellas, Steven R. Verdooner, Nicolas Villain, Kelly Virecoulon Giudici, Mark Watling, Lindsay A. Welikovitch, Janet Woodcock, Erfan Younesi, José L. Zugaza

Publikováno v: Neurobiology of Aging
Neurobiology of Aging, Elsevier, 2020, 96, pp.22-32. ⟨10.1016/j.neurobiolaging.2020.07.009⟩

Neuroinflammation, a key early pathomechanistic alteration of Alzheimer’s disease, may represent either a detrimental or a compensatory mechanism or both (according to the disease stage). YKL-40, a glycoprotein highly expressed in differentiated gl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b90065c443225c7b64787f11ddbf1a78
https://hal.archives-ouvertes.fr/hal-03491473

Sex and Gender Differences in the Brain Cholinergic System and in the Response to Therapy of Alzheimer Disease with Cholinesterase Inhibitors

Autor: Giancarlo Pepeu, Ezio Giacobini

Publikováno v: Current Alzheimer Research. 15:1077-1084

This review has two aims. First, to examine whether or not sex and gender may influence the brain cholinergic system in animals and in humans. Second, to examine the available evidence of sexually dimorphic response to the therapeutic and toxic effec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1859793dec7429e6820ca66367dade0d
https://doi.org/10.2174/1567205015666180613111504

Sex differences in Alzheimer disease - the gateway to precision medicine

Autor: Maria Teresa Ferretti, Sabina Misoch, Herman Depypere, Patrizia A. Chiesa, Enrica Cavedo, Hélène Girouard, Annemarie Schumacher Dimech, Antonella Santuccione Chadha, Harald Hampel, Maria Florencia Iulita, Ezio Giacobini, Francesca Baracchi

Publikováno v: Nature reviews. Neurology. 14(8)

Alzheimer disease (AD) is characterized by wide heterogeneity in cognitive and behavioural syndromes, risk factors and pathophysiological mechanisms. Addressing this phenotypic variation will be crucial for the development of precise and effective th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a7a751c00d0673f4154c9c701231913
https://pubmed.ncbi.nlm.nih.gov/29985474

Clinical trials and late-stage drug development for Alzheimer's disease: an appraisal from 1984 to 2014

Autor: Lon S. Schneider, Miia Kivipelto, Bengt Winblad, Ezio Giacobini, Howard Feldman, Luca Pani, Roy W. Jones, Patrizia Mecocci, Francesca Mangialasche, Valentina Mantua, Niels Andreasen

Publikováno v: Journal of internal medicine, vol 275, iss 3

The modern era of drug development for Alzheimer’s disease began with the proposal of the cholinergic hypothesis of memory impairment and the 1984 research criteria for Alzheimer’s disease. Since then, despite the evaluation of numerous potential

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::536bd45ce06b5332f5b1445a5d0bae89
https://doi.org/10.1111/joim.12191

Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers

Autor: Philip Scheltens, Heather M. Snyder, Valentina Garibotto, Oskar Hansson, Jonathan M. Schott, Niklas Mattsson, Mara ten Kate, Kaj Blennow, Jean-François Démonet, Frederik Barkhof, Charles Scerri, Giovanni B. Frisoni, Karl Herholz, Urs Peter Mosimann, Samia Hurst, Chiara Cerami, Alessandro Padovani, Marina Boccardi, Stefano F. Cappa, Andreas U. Monsch, Ezio Giacobini, Gabriel Gold, Valentina Gallo, Andrea Varrone, José-Luis Molinuevo, Bruno Dubois, Agnese Picco, Pieter Jelle Visser, Ida Sonni, Osman Ratib, Agneta Nordberg, Emiliano Albanese, Flavio Nobili, Corinna Porteri, Paolo Vineis, Clifford R. Jack, Anton F. Gietl, Patrick M.M. Bossuyt, Panteleimon Giannakopoulos, Yutaka Yasui, Konstantinos Chiotis, Bengt Winblad, Stefan J. Teipel, Laure Saint-Aubert, Maria C. Carrillo, Anders Lönneborg, Stefanie I. Becker, Karl-Olof Lövblad

Publikováno v: The Lancet Neurology, Vol. 16, No 8 (2017) pp. 661-676
Frisoni, G B, Boccardi, M, Barkhof, F, Blennow, K, Cappa, S, Chiotis, K, Démonet, J F, Garibotto, V, Giannakopoulos, P, Gietl, A, Hansson, O, Herholz, K, Jack, C R, Nobili, F, Nordberg, A, Snyder, H M, Ten Kate, M, Varrone, A, Albanese, E, Becker, S, Bossuyt, P, Carrillo, M C, Cerami, C, Dubois, B, Gallo, V, Giacobini, E, Gold, G, Hurst, S, Lönneborg, A, Lovblad, K O, Mattsson, N, Molinuevo, J L, Monsch, A U, Mosimann, U, Padovani, A, Picco, A, Porteri, C, Ratib, O, Saint-Aubert, L, Scerri, C, Scheltens, P, Schott, J M, Sonni, I, Teipel, S, Vineis, P, Visser, P J, Yasui, Y & Winblad, B 2017, ' Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers ', The Lancet Neurology, vol. 16, no. 8, pp. 661-676 . https://doi.org/10.1016/S1474-4422(17)30159-X
The lancet / Neurology 16(8), 661-676 (2017). doi:10.1016/S1474-4422(17)30159-X

The diagnosis of Alzheimer's disease can be improved by the use of biological measures. Biomarkers of functional impairment, neuronal loss, and protein deposition that can be assessed by neuroimaging (ie, MRI and PET) or CSF analysis are increasingly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f83feb975a24862796c41562837f1cf5
http://hdl.handle.net/11567/874037