Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Ezequiel, Marron Fernandez de Velasco"'
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 18 (2024)
IntroductionStress and trauma are significant risk factors for many neuropsychiatric disorders and diseases, including anxiety disorders. Stress-induced anxiety symptoms have been attributed to enhanced excitability in circuits controlling fear, anxi
Externí odkaz:
https://doaj.org/article/00ee864373c4445ab47446946296d706
Autor:
Reshma Gore, Tina Esmail, Kelsey Pflepsen, Ezequiel Marron Fernandez de Velasco, Kelley F. Kitto, Maureen S. Riedl, Andrea Karlen, R. Scott McIvor, Christopher N. Honda, Carolyn A. Fairbanks, Lucy Vulchanova
Publikováno v:
Frontiers in Pain Research, Vol 4 (2023)
Investigation of neural circuits underlying visceral pain is hampered by the difficulty in achieving selective manipulations of individual circuit components. In this study, we adapted a dual AAV approach, used for projection-specific transgene expre
Externí odkaz:
https://doaj.org/article/267d366a68584b458e50530348ee8317
Autor:
Kevin Lin, Ya-Chu Chang, Ezequiel Marron Fernandez de Velasco, Kevin Wickman, Chad L. Myers, Anja-Katrin Bielinsky
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101675- (2022)
Summary: Pooled lentiviral CRISPR-Cas9 screens are utilized for assessing the differential sensitivity or resistance of many single-gene knockouts to a compound. Here, we present a scalable approach for high-throughput compound screening by utilizing
Externí odkaz:
https://doaj.org/article/954cde00cbfd4802acf251d0cbe0cfb8
Autor:
Alexander G. J. Skorput, Reshma Gore, Rachel Schorn, Maureen S. Riedl, Ezequiel Marron Fernandez de Velasco, Bailey Hadlich, Kelley F. Kitto, Carolyn A. Fairbanks, Lucy Vulchanova
Publikováno v:
PLoS ONE, Vol 17, Iss 3 (2022)
Adeno-associated viral (AAV) vectors allow for site-specific and time-dependent genetic manipulation of neurons. However, for successful implementation of AAV vectors, major consideration must be given to the selection of viral serotype and route of
Externí odkaz:
https://doaj.org/article/6fb643af031c48b9a9569490d07460b9
Autor:
Allison Anderson, Kanchan Kulkarni, Ezequiel Marron Fernandez de Velasco, Nicholas Carlblom, Zhilian Xia, Atsushi Nakano, Kirill A. Martemyanov, Elena G. Tolkacheva, Kevin Wickman
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Abstract The atrial G protein-gated inwardly rectifying K+ (GIRK) channel is a critical mediator of parasympathetic influence on cardiac physiology. Here, we probed the details and relevance of the GIRK channel in mouse ventricle. mRNAs for the atria
Externí odkaz:
https://doaj.org/article/88e26c9be7d64664993ca42a8ef00461
Publikováno v:
American journal of physiology. Cell physiology. 323(2)
G protein-gated inwardly rectifying K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3624de6f4f3a75ce335bd6afe7d39a97
https://pubmed.ncbi.nlm.nih.gov/35704701
https://pubmed.ncbi.nlm.nih.gov/35704701
Autor:
Ezequiel Marron Fernandez de Velasco, Lei Zhang, Baovi N. Vo, Megan Tipps, Shannon Farris, Zhilian Xia, Allison Anderson, Nicholas Carlblom, C. David Weaver, Serena M. Dudek, Kevin Wickman
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Many neurotransmitters directly inhibit neurons by activating G protein-gated inwardly rectifying K+ (GIRK) channels, thereby moderating the influence of excitatory input on neuronal excitability. While most neuronal GIRK channels are formed
Externí odkaz:
https://doaj.org/article/71558560ec304bf5a09b60698ab9c399
Publikováno v:
American Journal of Physiology-Cell Physiology. 323:C439-C460
G protein-gated inwardly rectifying K+ (GIRK/Kir3) channels exert a critical inhibitory influence on neurons. Neuronal GIRK channels mediate the G protein-dependent, direct/postsynaptic inhibitory effect of many neurotransmitters including γ-aminobu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d3c8796f424188ff485b4686b9ea4ed
https://doi.org/10.1152/ajpcell.00102.2022
https://doi.org/10.1152/ajpcell.00102.2022
Autor:
Matthew V. Green, Thomas Pengo, Jonathan D. Raybuck, Tahmina Naqvi, Hannah M. McMullan, Jon E. Hawkinson, Ezequiel Marron Fernandez de Velasco, Brian S. Muntean, Kirill A. Martemyanov, Rachel Satterfield, Samuel M. Young, Stanley A. Thayer
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Synapse loss and dendritic damage correlate with cognitive decline in many neurodegenerative diseases, underlie neurodevelopmental disorders, and are associated with environmental and drug-induced CNS toxicities. However, screening assays designed to
Externí odkaz:
https://doaj.org/article/696e303d6aaf4c8384cab892bc02e5d6
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Central Nervous System Pharmacology - Neuropharmacology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09d80faeb3c21aa28ff77e09d49cf403
https://doi.org/10.1124/jpet.122.217940
https://doi.org/10.1124/jpet.122.217940