The human Shu complex promotes RAD51 activity by modulating RPA dynamics on ssDNA.

Autor: Hengel SR; University of Pittsburgh, School of Medicine, Department of Pharmacology and Chemical Biology, UPMC-Hillman Cancer Center, Pittsburgh, PA, USA. sarah.hengel@tufts.edu.; Tufts University, Department of Biology, Medford, MA, USA. sarah.hengel@tufts.edu., Oppenheimer KG; University of Pittsburgh, School of Medicine, Department of Pharmacology and Chemical Biology, UPMC-Hillman Cancer Center, Pittsburgh, PA, USA., Smith CM; University of Pittsburgh, School of Medicine, Department of Pharmacology and Chemical Biology, UPMC-Hillman Cancer Center, Pittsburgh, PA, USA.; University of North Carolina at Chapel Hill, Department of Pathology and Laboratory Medicine, Chapel Hill, NC, USA., Schaich MA; University of Pittsburgh, School of Medicine, Department of Pharmacology and Chemical Biology, UPMC-Hillman Cancer Center, Pittsburgh, PA, USA., Rein HL; University of Pittsburgh, School of Medicine, Department of Pharmacology and Chemical Biology, UPMC-Hillman Cancer Center, Pittsburgh, PA, USA., Martino J; University of Pittsburgh, School of Medicine, Department of Pharmacology and Chemical Biology, UPMC-Hillman Cancer Center, Pittsburgh, PA, USA.; GeneDx, Gaithersburg, MD, USA., Darrah KE; University of Pennsylvania School of Medicine, Penn Center for Genome Integrity, Department of Biochemistry and Biophysics, 421 Curie Boulevard, Philadelphia, PA, USA., Witham M; Tufts University, Department of Biology, Medford, MA, USA., Ezekwenna OC; Tufts University, Department of Biology, Medford, MA, USA., Burton KR; Tufts University, Department of Biology, Medford, MA, USA., Van Houten B; University of Pittsburgh, School of Medicine, Department of Pharmacology and Chemical Biology, UPMC-Hillman Cancer Center, Pittsburgh, PA, USA., Spies M; University of Iowa, Department of Biochemistry and Molecular Biology, Iowa City, IA, USA., Bernstein KA; University of Pittsburgh, School of Medicine, Department of Pharmacology and Chemical Biology, UPMC-Hillman Cancer Center, Pittsburgh, PA, USA. kara.bernstein@pennmedicine.upenn.edu.; University of Pennsylvania School of Medicine, Penn Center for Genome Integrity, Department of Biochemistry and Biophysics, 421 Curie Boulevard, Philadelphia, PA, USA. kara.bernstein@pennmedicine.upenn.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Aug 21; Vol. 15 (1), pp. 7197. Date of Electronic Publication: 2024 Aug 21.