Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Eyup Akgün"'
Autor:
Raini Dutta, Mary M. Lunzer, Jennifer L. Auger, Eyup Akgün, Philip S. Portoghese, Bryce A. Binstadt
Publikováno v:
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-10 (2018)
Abstract Background Pain accompanies rheumatoid arthritis and other chronic inflammatory conditions and is difficult to manage. Although opioids provide potent analgesia, chronic opioid use can cause tolerance and addiction. Recent studies have demon
Externí odkaz:
https://doaj.org/article/52d8dea972c8455d9122c10989aa592a
Autor:
Giuseppe Cataldo, Mary M. Lunzer, Eyup Akgün, Henry L. Wong, Philip S. Portoghese, Donald A. Simone
Publikováno v:
Neuroscience. 516:54-61
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c048e45c72204f282d9c739b70b78754
https://doi.org/10.1016/j.neuroscience.2023.02.006
https://doi.org/10.1016/j.neuroscience.2023.02.006
Autor:
Philip S. Portoghese, George L. Wilcox, Daniel J. Bruce, Michael Ansonoff, Defeng Tian, Eyup Akgün, Mary M. Lunzer, John E. Pintar, Jon E. Hawkinson
Publikováno v:
Biochemistry. 60:1413-1419
This report describes the unique pharmacological profile of FBNTI, a potent DOR antagonist that acts as a MOR agonist via an allosteric mechanism. Binding of FBNTI to opioid receptors expressed in HEK 293 cells revealed a 190-fold greater affinity fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa7c17f8b55b43255a8b507dd9a416a3
https://doi.org/10.1021/acs.biochem.0c00498
https://doi.org/10.1021/acs.biochem.0c00498
Publikováno v:
ACS Chemical Neuroscience. 10:2004-2011
Commonly prescribed opioid analgesics produce tolerance upon chronic use due in part to induction of hyperalgesia. Given that two reported bivalent ligands (MMG22 and MCC22) produce potent antinociception without tolerance only in inflamed mice, we h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccadb183f6f1e2ace28badfaa1330bb2
https://doi.org/10.1021/acschemneuro.8b00323
https://doi.org/10.1021/acschemneuro.8b00323
Autor:
Maureen S. Riedl, Eyup Akgün, Mary M. Lunzer, Carolyn A. Fairbanks, George L. Wilcox, Lucy Vulchanova, Cristina D. Peterson, Philip S. Portoghese, Kelley F. Kitto
Publikováno v:
Pain. 158:2431-2441
The mu opioid receptor (MOR) and metabotropic glutamate receptor 5 (mGluR5) are well-established pharmacological targets in the management of chronic pain. Both receptors are expressed in the spinal cord. MMG22, a bivalent ligand containing 2 pharmac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b547b3a12b5a90f86e074eb188c5fe13
https://doi.org/10.1097/j.pain.0000000000001050
https://doi.org/10.1097/j.pain.0000000000001050
Autor:
Eyup Akgün, Carolyn A. Fairbanks, Cristina D. Peterson, Sophia Lazzaroni, George L. Wilcox, Kelley F. Kitto, Phillip S. Portoghese, Daniel J. Bruce
Publikováno v:
Anesthesiology
Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New Background The long-term use of opioids for analgesia carries significant risk for tolerance, addiction, and diversion. These adverse effects are larg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02bf64c7f8a4550a765f578896534a37
https://europepmc.org/articles/PMC6693899/
https://europepmc.org/articles/PMC6693899/
Autor:
Samuel J. Erb, Catherine Harding-Rose, Sarah S. Shueb, Donald A. Simone, Philip S. Portoghese, Rebecca Speltz, Eyup Akgün, Mary M. Lunzer
Publikováno v:
Neuropharmacology
Pain is among the most common symptoms in cancer and approximately 90% of patients experience end-stage cancer pain. The management of cancer pain is challenging due to the significant side effects associated with opioids, and novel therapeutic appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a603729542c7bead8c31af8da1f094d4
https://europepmc.org/articles/PMC7210724/
https://europepmc.org/articles/PMC7210724/
Publikováno v:
Journal of Molecular Structure. 1101:33-40
In this study, two new Ce(III) complexes [Ce(L1)(NO3)3]∙H2O and [Ce(L2)(NO3)3]∙H2O were synthesized and characterized by spectroscopic and analytical methods where L1 and L2 are pentadentate diimine ligands. Molecular structure of [Ce(L1)(NO3)3]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab67f8ac8a3b32eb9c94db2364aa5c6c
https://doi.org/10.1016/j.molstruc.2015.08.016
https://doi.org/10.1016/j.molstruc.2015.08.016
Autor:
Gregory M. Vercellotti, John D. Belcher, Julie K. Olson, Philip S. Portoghese, Donald A. Simone, Eyup Akgün, Mary M. Lunzer, Giuseppe Cataldo
Publikováno v:
Pain. 159(7)
Sickle cell disease (SCD) is a chronic inflammatory disorder accompanied by chronic pain. In addition to ongoing pain and hyperalgesia, vaso-occlusive crises-induced pain can be chronic or episodic. Since analgesics typically used to treat pain are n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::099c00ecf9f478c5ec08280b8653c5bd
https://pubmed.ncbi.nlm.nih.gov/29578946
https://pubmed.ncbi.nlm.nih.gov/29578946
Figure S1. Structure of MCC22. MCC22 is a bivalent pharmacophore comprising a mu opioid receptor (MOR) agonist and a CCR5 antagonist joined by a 22-atom spacer. Figure S2. Representative histologic sections. The images show histologic sections of ank
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b77b13a1d3af511e7f7d991ea89bcb2a