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Combined liver-cytokine humanization comes to the rescue of circulating human red blood cells.

Autor: Song Y; Section of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT, USA.; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA.; Department of Hematologic Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China., Shan L; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. liang.shan@wustl.edu stephanie.halene@yale.edu richard.flavell@yale.edu.; Department of Medicine, Pathology and Immunology, Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA., Gbyli R; Section of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT, USA.; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA., Liu W; Section of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT, USA.; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA., Strowig T; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Helmholtz Centre for Infection Research, Braunschweig, Germany., Patel A; Section of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT, USA.; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA., Fu X; Section of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT, USA.; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA.; Department of Laboratory Medicine, Shenzhen Children's Hospital, Shenzhen, People's Republic of China., Wang X; Section of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT, USA.; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA.; Department of Hematology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China., Xu ML; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA., Gao Y; Section of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT, USA.; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA., Qin A; Section of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT, USA.; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA., Bruscia EM; Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA., Tebaldi T; Section of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT, USA.; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA.; Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Trento, Italy., Biancon G; Section of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT, USA.; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA., Mamillapalli P; Section of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT, USA.; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA., Urbonas D; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Eynon E; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Gonzalez DG; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA., Chen J; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Krause DS; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA.; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA., Alderman J; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Halene S; Section of Hematology, Department of Internal Medicine, Yale Cancer Center, and Yale Center for RNA Science and Medicine, Yale University School of Medicine, New Haven, CT, USA. liang.shan@wustl.edu stephanie.halene@yale.edu richard.flavell@yale.edu.; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA., Flavell RA; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. liang.shan@wustl.edu stephanie.halene@yale.edu richard.flavell@yale.edu.; Howard Hughes Medical Institute, Yale University, New Haven, CT, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2021 Mar 05; Vol. 371 (6533), pp. 1019-1025.

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