Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Eylem Kulkoyluoglu Cotul"'
Autor:
Michael F. Coleman, Eylem Kulkoyluoglu Cotul, Alexander J. Pfeil, Emily N. Devericks, Muhammad H. Safdar, Marvis Monteiro, Hao Chen, Alyssa N. Ho, Numair Attaar, Hannah M. Malian, Violet A. Kiesel, Alexis Ramos, Matthew Smith, Heena Panchal, Adam Mailloux, Dorothy Teegarden, Stephen D. Hursting, Michael K. Wendt
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-20 (2024)
Abstract Background Metabolic plasticity mediates breast cancer survival, growth, and immune evasion during metastasis. However, how tumor cell metabolism is influenced by and feeds back to regulate breast cancer progression are not fully understood.
Externí odkaz:
https://doaj.org/article/4bc52c528bb64c7f812b584380877b6e
Autor:
Aparna Shinde, Eylem Kulkoyluoglu Cotul, Hao Chen, Andrew Smith, Sarah Libring, Luis Solorio, Michael K. Wendt
Publikováno v:
Molecular Biomedicine, Vol 3, Iss 1, Pp 1-11 (2022)
Abstract Acquisition of resistance to targeted therapies remains a major clinical obstacle for the HER2+ subtype of breast cancer. Using an isogeneic progression series of HER2+ breast cancer metastasis we demonstrate that metastatic cells have an in
Externí odkaz:
https://doaj.org/article/04e68c777d484452a19e710b40dd4281
Autor:
Violet A. Kiesel, Madeline P. Sheeley, Michael F. Coleman, Eylem Kulkoyluoglu Cotul, Shawn S. Donkin, Stephen D. Hursting, Michael K. Wendt, Dorothy Teegarden
Publikováno v:
Cancer & Metabolism, Vol 9, Iss 1, Pp 1-13 (2021)
Abstract Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate (OAA), serving to replenish the tricarboxylic acid (TCA) cycle. In nonmalignant tissue, PC plays an essential role
Externí odkaz:
https://doaj.org/article/b686bcf2126847f6852b5d69aa73e389
Autor:
Zeynep Madak Erdogan, Debu Tripathy, Akshara Singareeka Raghavendra, John D. O'Neill, Evelyn Aranda, Benita S. Katzenellenbogen, Yvonne Ziegler, Ben Ho Park, David J. Shapiro, Nicole Hwajin Park, Eylem Kulkoyluoglu-Cotul, Ozan Berk Imir, Jenny Drnevich, Christine Chien, Ashlie Santaliz Casiano, Yu-Jeh Liu, Ayca Nazli Mogol, Qianying Zuo
Supplementary Table from Targeting Metabolic Adaptations in the Breast Cancer–Liver Metastatic Niche Using Dietary Approaches to Improve Endocrine Therapy Efficacy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08fcbd670914710b64958120b07b5ee2
https://doi.org/10.1158/1541-7786.22528229.v1
https://doi.org/10.1158/1541-7786.22528229.v1
Autor:
Zeynep Madak Erdogan, Debu Tripathy, Akshara Singareeka Raghavendra, John D. O'Neill, Evelyn Aranda, Benita S. Katzenellenbogen, Yvonne Ziegler, Ben Ho Park, David J. Shapiro, Nicole Hwajin Park, Eylem Kulkoyluoglu-Cotul, Ozan Berk Imir, Jenny Drnevich, Christine Chien, Ashlie Santaliz Casiano, Yu-Jeh Liu, Ayca Nazli Mogol, Qianying Zuo
Estrogen receptor–positive (ER+) metastatic tumors contribute to nearly 70% of breast cancer–related deaths. Most patients with ER+ metastatic breast cancer (MBC) undergo treatment with the estrogen receptor antagonist fulvestrant as standard of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10b4132d6b56eba42f1eb12d4ae2f62b
https://doi.org/10.1158/1541-7786.c.6545651.v1
https://doi.org/10.1158/1541-7786.c.6545651.v1
Autor:
Michael F. Coleman, Eylem Kulkoyluoglu Cotul, Alexander J. Pfeil, Emily N. Devericks, Muhammad H. Safdar, Hao Chen, Violet A. Kiesel, Dorothy Teegarden, Stephen D. Hursting, Michael K. Wendt
Publikováno v:
Cancer Research. 83:656-656
Metabolic reprogramming and immune evasion are established hallmarks of the tumor microenvironment (TME). Tumor metabolic dysregulation is a key mediator of tumor immune evasion. High levels of lactate produced by the tumor potently suppress antitumo
Hypoxia-mediated suppression of pyruvate carboxylase drives tumor microenvironment immunosuppression
Autor:
Michael F. Coleman, Eylem Kulkoyluoglu Cotul, Alexander J. Pfeil, Emily N. Devericks, Hao Chen, Violet A. Kiesel, Muhammad H. Safdar, Dorothy Teegarden, Stephen D. Hursting, Michael K. Wendt
Metabolic reprogramming and immune evasion are established hallmarks of the tumor microenvironment (TME). Growing evidence supports tumor metabolic dysregulation as an important mediator of tumor immune evasion. High TME levels of lactate potently su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a81caea5366cab71443c1317caee0edd
https://doi.org/10.1101/2022.04.06.487050
https://doi.org/10.1101/2022.04.06.487050
Autor:
Yu-Jeh Liu, Ozan Berk Imir, David J. Shapiro, Yvonne S. Ziegler, Qianying Zuo, Jenny Drnevich, Evelyn Aranda, Zeynep Madak-Erdogan, Ashlie Santaliz Casiano, C. Chien, Debu Tripathy, N. H. Park, A. N. Mogol, Eylem Kulkoyluoglu-Cotul, Benita S. Katzenellenbogen, Ben Ho Park, A. S. Raghavendra, John D. O’Neill
Publikováno v:
Mol Cancer Res
Estrogen receptor-positive (ER+) metastatic tumors contribute to nearly 70% of breast cancer-related deaths. Most patients with ER+ metastatic breast cancer (MBC) undergo treatment with the estrogen receptor antagonist fulvestrant (Fulv) as standard-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::194582c788d79991066b0614024b916a
https://doi.org/10.1101/2021.09.07.458711
https://doi.org/10.1101/2021.09.07.458711
Autor:
Meera Patel, Brandi Patrice Smith, Eylem Kulkoyluoglu-Cotul, Qianying Zuo, Gianluigi Rossi, Anna Maria Storniolo, Shoham Band, Jodi A. Flaws, Zeynep Madak-Erdogan, Ashlie Santaliz Casiano, Yiru C. Zhao, Rebecca L. Smith, John A. Katzenellenbogen, Natascia Marino, Kinga Wrobel, Sung Hoon Kim, Mariah L. Johnson
Publikováno v:
Cancer Research. 79:2494-2510
Obesity is a risk factor for postmenopausal estrogen receptor alpha (ERα)-positive (ER+) breast cancer. Molecular mechanisms underlying factors from plasma that contribute to this risk and how these mechanisms affect ERα signaling have yet to be el
Publikováno v:
Trends in Endocrinology & Metabolism. 30:25-38
Estrogens and estrogen receptors (ERs) regulate metabolism in both normal physiology and in disease. The metabolic characteristics of intrinsic breast cancer subtypes change based on their ER expression. Crosstalk between estrogen signaling elements