Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Eylan, Yutuc"'
Autor:
James Hennegan, Aled H. Bryant, Lauren Griffiths, Matthieu Trigano, Oliver J.M. Bartley, Joanna J. Bartlett, Carys Minahan, Willy Antoni Abreu de Oliveira, Eylan Yutuc, Sotirios Ntikas, Christos S. Bartsocas, Margarita Markouri, Eleni Antoniadou, Ioanna Laina, Owain W. Howell, Meng Li, Yuqin Wang, William J. Griffiths, Emma L. Lane, Mariah J. Lelos, Spyridon Theofilopoulos
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108670- (2024)
Summary: Dysregulated cholesterol metabolism has been linked to neurodegeneration. We previously found that free, non-esterified, 7α,(25R)26-dihydroxycholesterol (7α,26-diHC), was significantly elevated in the cerebrospinal fluid of patients with P
Externí odkaz:
https://doaj.org/article/cc11eaec18cb42d988985f04f6f16725
Autor:
Alison Dickson, Eylan Yutuc, Catherine A. Thornton, James E. Dunford, Udo Oppermann, Yuqin Wang, William J. Griffiths
Publikováno v:
Open Biology, Vol 13, Iss 5 (2023)
Most biologically active oxysterols have a 3β-hydroxy-5-ene function in the ring system with an additional site of oxidation at C-7 or on the side-chain. In blood plasma oxysterols with a 7α-hydroxy group are also observed with the alternative 3-ox
Externí odkaz:
https://doaj.org/article/17d9e78ab32f4d83adb33f794fb2752d
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
The aim of this study was to identify oxysterols and any down-stream metabolites in placenta, umbilical cord blood plasma, maternal plasma and amniotic fluid to enhance our knowledge of the involvement of these molecules in pregnancy. We confirm the
Externí odkaz:
https://doaj.org/article/8398923c7ed5473f819bac8cda43fde6
Autor:
Nicholas J. Hudson, Antonio Reverter, William J. Griffiths, Eylan Yutuc, Yuqin Wang, Angela Jeanes, Sean McWilliam, David W. Pethick, Paul L. Greenwood
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-23 (2020)
Abstract Background This study used a genome-wide screen of gene expression to better understand the metabolic and functional differences between commercially valuable intramuscular fat (IMF) and commercially wasteful subcutaneous (SC) fat depots in
Externí odkaz:
https://doaj.org/article/5da402a1a6004aa7b0a3321a239f0d5e
Autor:
William J. Griffiths, Jonas Abdel-Khalik, Sarah F. Moore, Ruwani S. Wijeyekoon, Peter J. Crick, Eylan Yutuc, Krista Farrell, David P. Breen, Caroline H. Williams-Gray, Spyridon Theofilopoulos, Ernest Arenas, Miles Trupp, Roger A. Barker, Yuqin Wang
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Disordered cholesterol metabolism is linked to neurodegeneration. In this study we investigated the profile of cholesterol metabolites found in the cerebrospinal fluid (CSF) of Parkinson’s disease (PD) patients. When adjustments were made for confo
Externí odkaz:
https://doaj.org/article/abaae19036454c66a3664ff79c96a45e
Publikováno v:
Mass Spectrometry for Lipidomics. :481-508
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64e6c9672601c01faff39fcd527397e0
https://doi.org/10.1002/9783527836512.ch16
https://doi.org/10.1002/9783527836512.ch16
Autor:
Philip Höflinger, Stefan Hauser, Eylan Yutuc, Holger Hengel, Lauren Griffiths, Florentine Radelfahr, Owain W. Howell, Yuqin Wang, Sonja L. Connor, P. Barton Duell, Andrea E. DeBarber, Peter Martus, Dieter Lütjohann, William J. Griffiths, Ludger Schöls
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100078- (2021)
Cerebrotendinous xanthomatosis (CTX) is caused by autosomal recessive loss-of-function mutations in CYP27A1, a gene encoding cytochrome p450 oxidase essential for bile acid synthesis, resulting in altered bile acid and lipid metabolism. Here, we aime
Externí odkaz:
https://doaj.org/article/41d7e6fd58f7466ca39ad0e0f6bfc8e4
Autor:
William J. Griffiths, Ian Gilmore, Eylan Yutuc, Jonas Abdel-Khalik, Peter J. Crick, Thomas Hearn, Alison Dickson, Brian W. Bigger, Teresa Hoi-Yee Wu, Anu Goenka, Arunabha Ghosh, Simon A. Jones, Yuqin Wang
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 6, Pp 1058-1070 (2018)
7-Oxocholesterol (7-OC), 5,6-epoxycholesterol (5,6-EC), and its hydrolysis product cholestane-3β,5α,6β-triol (3β,5α,6β-triol) are normally minor oxysterols in human samples; however, in disease, their levels may be greatly elevated. This is the
Externí odkaz:
https://doaj.org/article/22e61a656a04415999d23ca94e60b770
Autor:
Jonas Abdel-Khalik, Eylan Yutuc, Peter J. Crick, Jan-Åke Gustafsson, Margaret Warner, Gustavo Roman, Kevin Talbot, Elizabeth Gray, William J. Griffiths, Martin R. Turner, Yuqin Wang
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 1, Pp 267-278 (2017)
As neurons die, cholesterol is released in the central nervous system (CNS); hence, this sterol and its metabolites may represent a biomarker of neurodegeneration, including in amyotrophic lateral sclerosis (ALS), in which altered cholesterol levels
Externí odkaz:
https://doaj.org/article/9d8e6d3705504fb48c95baea8195e5c8
Autor:
null Alison Dickson, null Eylan Yutuc, null Catherine A. Thornton, null James E. Dunford, null Udo Oppermann, null Yuqin Wang, null William J. Griffiths
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ef0dc841ebba91fba0dd4b07b0fcf64
https://doi.org/10.1098/rsob.220313/v2/response1
https://doi.org/10.1098/rsob.220313/v2/response1
