Výsledky vyhledávání - "Eye Proteins/genetics/metabolism"

Pax6 Is a Key Component of Regulated Glucagon Secretion

Autor: Caroline Poisson, Mounia Heddad Masson, Jacques Philippe, Yvan Gosmain, Audrey Guérardel, Claire Cheyssac

Publikováno v: Endocrinology, Vol. 153, No 9 (2012) pp. 4204-15

The Pax6 transcription factor is crucial for pancreatic α-cells. Indeed, Pax6-deficient mouse models are characterized by markedly altered α-cell differentiation. Our objective was to investigate the role of Pax6 in glucagon secretion process. We u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e4e08a66a1b2e4c08788194ee66248e
https://doi.org/10.1210/en.2012-1425

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Multifunctional RNA processing protein SRm160 induces apoptosis and regulates eye and genital development in Drosophila

Autor: Yong-Zhen Xu, Aryn H. Gittis, Chen Qiu, Leonard Rabinow, Yu-Jie Fan, François Juge

Publikováno v: Genetics
Genetics, Genetics Society of America, 2014, 197 (4), pp.1251--65. ⟨10.1534/genetics.114.164434⟩

SRm160 is an SR-like protein implicated in multiple steps of RNA processing and nucleocytoplasmic export. Although its biochemical functions have been extensively described, its genetic interactions and potential participation in signaling pathways r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aebb28d9190af512af4a313f659562d3
https://hal.archives-ouvertes.fr/hal-02191571

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Whole exome sequencing of a dominant retinitis pigmentosa family identifies a novel deletion in PRPF31

Autor: Jason R. Willer, Julien Bryois, Adda Villanueva, Nicholas Katsanis, Erica E. Davis, Emmanouil T. Dermitzakis

Publikováno v: Investigative Ophthalmology & Visual Science, Vol. 55, No 4 (2014) pp. 2121-2129

PURPOSE Mutations at some retinitis pigmentosa (RP) loci are associated with variable penetrance and expressivity, exacerbating diagnostic challenges. The purpose of this study was to dissect the genetic underpinnings of nonsyndromic RP with variable

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4f7d5fa1d0cc82a41b93c44feaef587
https://pubmed.ncbi.nlm.nih.gov/24595387

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Glucagon gene expression in the endocrine pancreas: the role of the transcription factor Pax6 in α-cell differentiation, glucagon biosynthesis and secretion

Autor: Charna Dibner, Claire Cheyssac, Yvan Gosmain, M. Heddad Masson, Jacques Philippe

Publikováno v: Diabetes, Obesity and Metabolism, Vol. 13 Suppl 1 (2011) pp. 31-8
Diabetes obesity & metabolism

The glucagon gene is expressed in α-cells of the pancreas, L cells of the intestine and the hypothalamus. The determinants of the α-cell-specific expression of the glucagon gene are not fully characterized, although Arx, Pax6 and Foxa2 are critical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9662250ca3fa0f22320257e53babf73d
https://archive-ouverte.unige.ch/unige:25626

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Vitreous treatment of cultured human RPE cells results in differential expression of 10 new genes

Autor: Kociok N, Arno Hueber, Esser P, Schraermeyer U, Thumann G, Tt, Luther, Jordan J, Welsandt G, Kirchhof B

Publikováno v: Investigative Ophthalmology & Visual Science, Vol. 43, No 7 (2002) pp. 2474-2480
ResearcherID
Europe PubMed Central

To analyze the differential gene expression in cultured human retinal pigment epithelial (RPE) cells after treatment with vitreous.Cultured human RPE cells were incubated for 48 hours with 25% human vitreous from donor eyes. Total RNA from treated an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9ebcac6b0311f78a5731692f342ec4c7
https://archive-ouverte.unige.ch/unige:89328

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