Zobrazeno 1 - 10
of 245
pro vyhledávání: '"Eyasu, Makonnen"'
Autor:
Abel Gedefaw, Birkneh Tilahun Tadesse, Yifru Berhan, Eyasu Makonnen, Stefano Vella, Eleni Aklillu
Publikováno v:
BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background A dolutegravir (DTG)-based antiretroviral regimen has been rolled out for pregnant women in low- and middle-income countries since 2020. However, available safety data are limited to a few clinical trials and observational studies
Externí odkaz:
https://doaj.org/article/db669a576ae44d25a3dd400e082886c3
Autor:
Tigist Dires Gebreyesus, Eyasu Makonnen, Nigus Fikrie Telele, Abbie Barry, Rajabu Hussein Mnkugwe, Heran Gerba, Marja-Liisa Dahl, Eleni Aklillu
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Metabolism of praziquantel (PZQ), a racemic mixture and the only drug approved to treat S. mansoni infection, is mediated by genetically polymorphic enzymes. Periodic school-based mass drug administration (MDA) with PZQ is the core intervent
Externí odkaz:
https://doaj.org/article/2bafea5de4f74380983c947626a0106c
Autor:
Tigist Dires Gebreyesus, Eyasu Makonnen, Tafesse Tadele, Kalkidan Mekete, Habtamu Gashaw, Heran Gerba, Eleni Aklillu
Publikováno v:
Infectious Diseases of Poverty, Vol 13, Iss 1, Pp 1-11 (2024)
Abstract Background Mass drug administration (MDA) program of albendazole to at-risk populations as preventive chemotherapy is the core public health intervention to control soil-transmitted helminths (STHs). Achieving this goal relies on drug effect
Externí odkaz:
https://doaj.org/article/84268f179de74eef88e6055d170d0605
Autor:
Tafese Tadele, Ayalew Astatkie, Birkneh Tilahun Tadesse, Eyasu Makonnen, Eleni Aklillu, Solomon Mequanente Abay
Publikováno v:
Tropical Medicine and Health, Vol 51, Iss 1, Pp 1-12 (2023)
Abstract Background Preventive chemotherapy with a single dose of praziquantel given to an all-at-risk population through mass drug administration is the cornerstone intervention to control and eliminate schistosomiasis as a public health problem. Th
Externí odkaz:
https://doaj.org/article/8bbbb662a6b149cbbb20ef773df44713
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Unfavorable treatment outcomes for tuberculosis (TB) treatment might result from altered plasma exposure to antitubercular drugs in TB patients. The present study investigated the distribution of the N-Acetyltransferase 2 (NAT2) genotype, is
Externí odkaz:
https://doaj.org/article/d621e6b3cc764e4da3acc99dd1755330
Autor:
Adugna Chala, Eliford Ngaimisi Kitabi, Jemal Hussien Ahmed, Birkneh Tilahun Tadesse, Tolossa Eticha Chaka, Eyasu Makonnen, Eleni Aklillu
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 6, Pp 783-794 (2023)
Abstract Despite the potential for efavirenz (EFV) to be an effective alternative antiretroviral agent, its sources of wide inter‐ and intra‐individual pharmacokinetic (PK) variability are not well‐characterized in children. We investigated the
Externí odkaz:
https://doaj.org/article/7cf022a5a3bd475c8fc6c38a045b754a
Autor:
Michele Joseph, Yimtubeznash Woldeamanuel, Girmay Medhin, Tsegahun Manyazewal, Abebaw Fekadu, Eyasu Makonnen
Publikováno v:
Tropical Medicine and Health, Vol 51, Iss 1, Pp 1-9 (2023)
Abstract Background Tetanus remains a severe life-threatening infectious disease and neurological disorder in many parts of the world, where immunization programs are suboptimal. Any human injury or trauma has the possibility of getting infected with
Externí odkaz:
https://doaj.org/article/aaaab279e1d241aa8430f878a8157b86
Publikováno v:
Systematic Reviews, Vol 12, Iss 1, Pp 1-9 (2023)
Abstract Background Antimicrobial resistance is currently a recognized global health problem stemming from poor antibiotic stewardship by health workers and inappropriate antimicrobial use by patients. Data showing the extent of poor antimicrobial st
Externí odkaz:
https://doaj.org/article/529052db46294af091b9b1f8fe4daab0
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Efavirenz is metabolized by CYP2B6, an inducible enzyme whose expression is regulated by the constitutive androstane receptor and pregnane X receptor nuclear receptors. CAR and PXR are encoded by genetically polymorphic NR1I2 and NR1I3, resp
Externí odkaz:
https://doaj.org/article/6b81b561214a417a8819857d758f7bd6
Autor:
Tigist Dires Gebreyesus, Eyasu Makonnen, Tafesse Tadele, Kalkidan Mekete, Habtamu Gashaw, Heran Gerba, Eleni Aklillu
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: The World Health Organization recommends efficacy and safety surveillance of anti-helminths used in mass drug administration campaigns. We evaluated the effectiveness of single-dose praziquantel against Schistosoma mansoni infection, and
Externí odkaz:
https://doaj.org/article/eb0b8e46757146acadf48c614d6595ed