Three-dimensional imaging mass cytometry for highly multiplexed molecular and cellular mapping of tissues and the tumor microenvironment

Autor: Kuett, L, Catena, R, ��zcan, A, Pl��ss, A, Ali, HR, Sa���d, MA, Alon, S, Aparicio, S, Battistoni, G, Balasubramanian, Shankar, Becker, R, Bodenmiller, B, Boyden, ES, Bressan, D, Bruna, A, Burger, M, Caldas, Carlos, Callari, M, Cannell, IG, Casbolt, H, Chornay, N, Cui, Y, Dariush, Aliakbar, Dinh, K, Emenari, A, Eyal-Lubling, Y, Fan, J, Fatemi, A, Fisher, E, Gonz��lez-Solares, EA, Gonz��lez-Fern��ndez, C, Goodwin, D, Greenwood, W, Grimaldi, F, Hannon, GJ, Harris, S, Jauset, C, Joyce, JA, Karagiannis, ED, Kova��evi��, T, Kunes, R, Yolda��, AK, Lai, D, Laks, E, Lee, H, Lee, M, Lerda, G, Li, Y, McPherson, A, Millar, N, Mulvey, CM, Nugent, I, O���Flanagan, CH, Paez-Ribes, M, Pearsall, I, Qosaj, F, Roth, AJ, Rueda, OM, Ruiz, T, Sawicka, K, Sep��lveda, LA, Shah, SP, Shea, A, Sinha, A, Smith, A, Tavar��, S, Tietscher, S, V��zquez-Garc��a, I, Vogl, SL, Walton, NA, Wassie, AT, Watson, SS, Weselak, J, Wild, SA, Williams, E, Windhager, J, Xia, C, Zheng, P, Zhuang, X, Schraml, P, Moch, H, De Souza, N

A holistic understanding of tissue and organ structure and function requires the detection of molecular constituents in their original three-dimensional (3D) context. Imaging mass cytometry (IMC) enables simultaneous detection of up to 40 antigens an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5caec60c9a651d8bc18ad1dee6053ac
https://www.repository.cam.ac.uk/handle/1810/333191

Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response

Autor: Georgopoulou, Dimitra, Callari, Maurizio, Rueda, Oscar M., Shea, Abigail, Martin, Alistair, Giovannetti, Agnese, Qosaj, Fatime, Dariush, Ali, Chin, Suet-Feung, Carnevalli, Larissa S., Provenzano, Elena, Greenwood, Wendy, Lerda, Giulia, Esmaeilishirazifard, Elham, O’Reilly, Martin, Serra, Violeta, Bressan, Dario, Mills, Gordon B., Ali, H. Raza, Cosulich, Sabina S., Hannon, Gregory J., Bruna, Alejandra, Caldas, Carlos, Ali, H. R., Al Sa’d, M., Alon, S., Aparicio, S., Battistoni, G., Balasubramanian, S., Becker, R., Bodenmiller, B., Boyden, E. S., Bressan, D., Bruna, A., Burger, Marcel, Caldas, C., Callari, M., Cannell, I. G., Casbolt, H., Chornay, N., Cui, Y., Dariush, A., Dinh, K., Emenari, A., Eyal-Lubling, Y., Fan, J., Fatemi, A., Fisher, E., González-Solares, E. A., González-Fernández, C., Goodwin, D., Greenwood, W., Grimaldi, F., Hannon, G. J., Harris, O., Harris, S., Jauset, C., Joyce, J. A., Karagiannis, E. D., Kovačević, T., Kuett, L., Kunes, R., Küpcü, Yoldaş A., Lai, D., Laks, E., Lee, H., Lee, M., Lerda, G., Li, Y., McPherson, A., Millar, N., Mulvey, C. M., Nugent, F., O’Flanagan, C. H., Paez-Ribes, M., Pearsall, I., Qosaj, F., Roth, A. J., Rueda, O. M., Ruiz, T., Sawicka, K., Sepúlveda, L. A., Shah, S. P., Shea, A., Sinha, A., Smith, A., Tavaré, S., Tietscher, S., Vázquez-García, I., Vogl, S. L., Walton, N. A., Wassie, A. T., Watson, S. S., Weselak, J., Wild, S. A., Williams, E., Windhager, J., Whitmarsh, T., Xia, C., Zheng, P., Zhuang, X.

Funder: Cancer Research UK (CRUK); doi: https://doi.org/10.13039/501100000289
Funder: AstraZeneca; doi: https://doi.org/10.13039/100004325
The heterogeneity of breast cancer plays a major role in drug response and resistance and has been ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f430d7cb89f2265521776cbb40a97a45

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Modeling Drug Responses and Evolutionary Dynamics using Patient-Derived Xenografts Reveals Precision Medicine Strategies for Triple Negative Breast Cancer.

Autor: Shea A; Institute of Cancer Research, London, United Kingdom., Eyal-Lubling Y; University of Cambridge, Cambridge, United Kingdom., Guerrero-Romero D; University of Cambridge, Cambridge, United Kingdom., Manzano Garcia R; University of Cambridge, Cambridge, United Kingdom., Greenwood W; University of Cambridge, Cambridge, United Kingdom., O'Reilly M; University of Cambridge, Cambridge, United Kingdom., Georgopoulou D; University of Cambridge, Cambridge, United Kingdom., Callari M; Michelangelo Foundation, Milan, Italy., Lerda G; University of Cambridge, Cambridge, United Kingdom., Wix S; University of Cambridge, Cambridge, United Kingdom., Giovannetti A; University of Cambridge, Cambridge, United Kingdom., Masina R; University of Cambridge, Cambridge, United Kingdom., Esmaeilishirazifard E; University of Cambridge, Cambridge, United Kingdom., Cope W; Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom., Martin AG; University of Cambridge, Cambridge, United Kingdom., Nagano A; Queen Mary University of London, London, United Kingdom., Young L; University of Cambridge, Cambridge, United Kingdom., Kupczak S; Cancer Research UK Cambridge Center, Cambridgeshire, United Kingdom., Cheng Y; University of Cambridge, Cambridge, United Kingdom., Bardwell H; University of Cambridge, Cambridge, United Kingdom., Provenzano E; Cambridge University Hospitals NHS Foundation Trust, United Kingdom., Kane J; University of Cambridge, Cambridge, United Kingdom., Lay J; University of Cambridge, Cambridge, United Kingdom., Grybowicz L; Cambridge University Hospitals NHS Foundation Trust, United Kingdom., McAdam K; Cambridge University NHS Foundation Trust, United Kingdom., Caldas C; University of Cambridge, Cambridge, United Kingdom., Abraham J; University of Cambridge, Cambridge, United Kingdom., Rueda OM; University of Cambridge, Cambridge, United Kingdom., Bruna A; Institute of Cancer Research, London, United Kingdom.

Publikováno v: Cancer research [Cancer Res] 2024 Nov 08. Date of Electronic Publication: 2024 Nov 08.