Utilizing Designed Receptors Exclusively Activated by Designer Drug Chemogenetic Tools to Identify Beneficial G Protein–Coupled Receptor Signaling for Fibrosis

Autor: Tzu-Ming Wang, Andrea M. Peier, Eric S. Muise, Ji Zhang, Eyal Vardy, Richard Visconti, Ashita Vadlamudi, Shirly Pinto

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 375:357-366

Fibrosis or accumulation of extracellular matrix is an evolutionarily conserved mechanism adopted by an organism as a response to chronic injury. Excessive fibrosis, however, leads to disruption of organ homeostasis and is a common feature of many ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9a9b5923c3cd63cd2fad83dc1204279
https://doi.org/10.1124/jpet.120.000103

Single Amino Acid Variation Underlies Species-Specific Sensitivity to Amphibian Skin-Derived Opioid-like Peptides

Autor: Richard B. Westkaemper, Andrew J. Rennekamp, Vsevolod Katritch, Eyal Vardy, Bryan L. Roth, Craig W. Stevens, Philip D. Mosier, Raymond C. Stevens, Wesley K. Kroeze, Randall T. Peterson, Maria F. Sassano

Publikováno v: Chemistry & Biology. 22(6):764-775

It has been suggested that the evolution of vertebrate opioid receptors (ORs) follow a vector of increased functionality. Here we test this idea comparing human and frog ORs. Interestingly, some of the most potent opioid peptides known have been isol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1668063a6a44df480cf6de3daeaa29b

Structural Basis for Molecular Recognition at Serotonin Receptors

Autor: Chenghai Zhang, Vsevolod Katritch, Karsten Melcher, Vadim Cherezov, Jinming Ma, Daniel Wacker, Fang Bai, Raymond C. Stevens, John D. McCorvy, X. Edward Zhou, Eyal Vardy, Gye Won Han, Hualiang Jiang, H. Eric Xu, Xi Ping Huang, Huixian Wu, Bryan L. Roth, Xiang Gao, Wei Liu, Huaiyu Yang, Yi Jiang, Chong Wang, Linlin Yang

Publikováno v: Science. 340:610-614

Dissecting Serotonin Receptors Serotonin receptors are the targets for many widely used drugs prescribed to treat ailments from depression to obesity and migraine headaches (see the Perspective by Palczewski and Kiser ). C. Wang et al. (p. 610 , publ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f44ace716378921b59ee455d5026048
https://doi.org/10.1126/science.1232807

Role of Ventral Subiculum in Context-Induced Relapse to Alcohol Seeking after Punishment-Imposed Abstinence

Autor: Yavin Shaham, Brandon K. Harvey, Nathan J. Marchant, Sweta Adhikary, Konstantin Kaganovsky, Thomas E. Prisinzano, Leslie R. Whitaker, Robert Conor Heins, Eyal Vardy, Antonello Bonci, Bruce T. Hope, Erin J. Campbell, Jennifer M. Bossert

Publikováno v: Journal of Neuroscience, 36(11), 3281-3294. Society for Neuroscience
Marchant, N J, Campbell, E J, Whitaker, L R, Harvey, B K, Kaganovsky, K, Adhikary, S, Hope, B T, Heins, R C, Prisinzano, T E, Vardy, E, Bonci, A, Bossert, J M & Shaham, Y 2016, ' Role of ventral subiculum in context-induced relapse to alcohol seeking after punishment-imposed abstinence ', Journal of Neuroscience, vol. 36, no. 11, pp. 3281-3294 . https://doi.org/10.1523/JNEUROSCI.4299-15.2016

In many human alcoholics, abstinence is self-imposed because of the negative consequences of excessive alcohol use, and relapse is often triggered by exposure to environmental contexts associated with prior alcohol drinking. We recently developed a r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23dd6c88ea3d29173efa44a738cdc7c7
https://europepmc.org/articles/PMC4792939/

Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic

Autor: Claudio Trapella, Vadim Cherezov, Eugene Chun, Xi Ping Huang, Eyal Vardy, Bryan L. Roth, Huixian Wu, Remo Guerrini, Vsevolod Katritch, Wei-Wei Liu, Girolamo Calo, Aaron Thompson, Raymond C. Stevens

Publikováno v: Nature

Members of the Opioid Receptor (OR) family of G protein-coupled receptors (GPCRs) are found throughout the peripheral and central nervous system where they play key roles in nociception and analgesia. Unlike the classical ORs, δ–OR, κ–OR,1 and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ac57e77ff58da9343c39d841e71656f
https://doi.org/10.1038/nature11085