Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Eyal Sobol"'
Publikováno v:
Toxicology and applied pharmacology. 343
5-Methoxy-2-aminoindane (MEAI) is a novel psychoactive aminoindane derivative, exerting euphoric, alcohol-like tipsy experience and reduced desire to consume alcoholic beverages. Our previous toxicological evaluation of MEAI in rats, clearly indicate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcfdc55cb216531d586865997c891285
https://pubmed.ncbi.nlm.nih.gov/29458138
https://pubmed.ncbi.nlm.nih.gov/29458138
Autor:
Bogdan J. Wlodarczyk, John G. Lamb, H. Steve White, Boris Yagen, Meir Bialer, Eyal Sobol, Richard H. Finnell
Publikováno v:
Epilepsy Research. 73:75-84
N-methoxy-2,2,3,3-tetramethylcyclopropane carboxamide (OM-TMCD) is a methoxyamide derivative of a cyclopropyl analogue of valproic acid (VPA). The structural considerations used in the design of OM-TMCD were aimed to enhance OM-TMCD anticonvulsant po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f452f80e012cd0c287402e573bb57db
https://doi.org/10.1016/j.eplepsyres.2006.08.004
https://doi.org/10.1016/j.eplepsyres.2006.08.004
Publikováno v:
Journal of psychopharmacology (Oxford, England). 29(6)
3-Methyl-methcathinone (3-MMC) is a novel, synthetic cathinone analog, recently linked to poisoning events among recreational users. The lack of pharmacological data on 3-MMC, prompted us to explore its pharmacokinetic profile as well as its effect o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc2e67dcb901f4126a30ebd4477eab45
https://pubmed.ncbi.nlm.nih.gov/25804420
https://pubmed.ncbi.nlm.nih.gov/25804420
Autor:
Boris Yagen, Yuko Onishi, Yoshinobu Aoki, Meir Bialer, Michio Fujiwara, Akinobu Okada, Eyal Sobol
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 77:227-233
BACKGROUND: Although valproic acid (VPA) is used extensively for treating various kinds of epilepsies, it is well known that it causes neural tube and skeletal defects in both humans and animals. The amide and urea derivatives of the tetramethylcylco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c165239bed8762cab57bc192f88a5e17
https://doi.org/10.1002/bdrb.20078
https://doi.org/10.1002/bdrb.20078
Autor:
Eyal Sobol, Meir Bialer
Publikováno v:
Biopharmaceutics & Drug Disposition. 26:51-58
It is well known that in the two-compartment open body model the values of apparent volume of distribution (V(beta)) and volume of distribution at steady state (V(ss)) are never identical. There are at least two conditions when V(beta) significantly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ad155882a8721b59492cc36d30e11b
https://doi.org/10.1002/bdd.431
https://doi.org/10.1002/bdd.431
Publikováno v:
Journal of Medicinal Chemistry. 47:4316-4326
Although valproic acid (VPA) is an extensively used antiepileptic drug for treatment of various kinds of epilepsies, it has been proven to possess two life-threatening side effects: hepatotoxicity and teratogenicity. Amide and urea derivatives of 2,2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::753be8eb3771db0f42005b7f84ce27bd
https://doi.org/10.1021/jm0498351
https://doi.org/10.1021/jm0498351
Publikováno v:
Epilepsia. 45:737-744
Summary: Purpose: Valproic acid (VPA), one of the widely used antiepileptic drugs (AEDs), was recently found to inhibit histone deacetylases (HDACs). HDAC inhibitors of a wide range of structures, such as hydroxamic acids, carboxylic acids, and cycli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b94c5a51a763b004f79cc390523ba205
https://doi.org/10.1111/j.0013-9580.2004.00104.x
https://doi.org/10.1111/j.0013-9580.2004.00104.x
Autor:
Eyal Sobol, Meir Bialer
Publikováno v:
Biopharmaceutics & Drug Disposition. 25:157-162
In the one-compartment model following i.v. administration the mean residence time (MRT) of a drug is always greater than its half-life (t(1/2)). However, following i.v. administration, drug plasma concentration (C) versus time (t) is best described
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d426a763de28f3047842acf5f82dd19e
https://doi.org/10.1002/bdd.396
https://doi.org/10.1002/bdd.396
Autor:
Eyal Sobol, Meir Bialer
Publikováno v:
Biopharmaceutics & Drug Disposition. 25:99-101
Pharmacokinetic textbooks state that the (apparent) volume of distribution based on drug concentration in plasma (V or Vbeta) is always greater than the volume of distribution (apparent) under steady state conditions (Vss), but do not provide a gener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9581851b6298d5e7f1642fcfaa204747
https://doi.org/10.1002/bdd.372
https://doi.org/10.1002/bdd.372
Autor:
Bogdan J. Wlodarczyk, H. Steve White, Richard H. Finnell, Orit Pappo, Meir Bialer, Karen S. Wilcox, Boris Yagen, John G. Lamb, Eyal Sobol
Publikováno v:
Neuropharmacology. 51(4)
2,2,3,3-Tetramethylcyclopropanecarbonylurea (TMCU) is an amide derivative of a tetramethylcyclopropyl analogue of valproic acid (VPA), one of the leading antiepileptic drugs. Structural considerations used in the design of TMCU aimed to enhance the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a331e55107464535d74300f47d05af1
https://pubmed.ncbi.nlm.nih.gov/16890251
https://pubmed.ncbi.nlm.nih.gov/16890251