Zobrazeno 1 - 10
of 1 613
pro vyhledávání: '"Extrasynaptic"'
Publikováno v:
The Journal of Headache and Pain, Vol 25, Iss 1, Pp 1-15 (2024)
Abstract Background GABA, a key inhibitory neurotransmitter, has synaptic and extrasynaptic receptors on the postsynaptic neuron. Background GABA, which spills over from the synaptic cleft, acts on extrasynaptic delta subunit containing GABAA recepto
Externí odkaz:
https://doaj.org/article/42431302e7c843399a5a0d1659566016
Autor:
Yusheng Sui, Martin Mortensen, Banghao Yuan, Martin W. Nicholson, Trevor G. Smart, Jasmina N. Jovanovic
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
GABAA receptors (γ-aminobutyric acid-gated receptors type A; GABAARs), the major structural and functional postsynaptic components of inhibitory synapses in the mammalian brain, belong to a family of GABA-gated Cl−/HCO3− ion channels. They are a
Externí odkaz:
https://doaj.org/article/529b606f5b0f412881dc9abf0b3d1af1
Autor:
Yosuke Yawata, Ryoichi Tashima, Hiroyuki Aritomi, Shinji Shimada, Tsukasa Onodera, Teruhiko Taishi, Keiko Takasu, Koichi Ogawa
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Effective treatments for major depressive disorder (MDD) have long been needed. One hypothesis for the mechanism of depression involves a decrease in neuroactive steroids such as allopregnanolone, an endogenous positive allosteric modulator of the γ
Externí odkaz:
https://doaj.org/article/970cc357d40247e9828dd85ac033555c
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-29 (2023)
Abstract Stroke and late-onset Alzheimer’s disease (AD) are risk factors for each other; the comorbidity of these brain disorders in aging individuals represents a significant challenge in basic research and clinical practice. The similarities and
Externí odkaz:
https://doaj.org/article/e1512064a32a46c7a8810611d864651b
Autor:
Keiko Takasu, Yosuke Yawata, Ryoichi Tashima, Hiroyuki Aritomi, Shinji Shimada, Tsukasa Onodera, Teruhiko Taishi, Koichi Ogawa
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2024)
The rapid relief of depressive symptoms is a major medical requirement for effective treatments for major depressive disorder (MDD). A decrease in neuroactive steroids contributes to the pathophysiological mechanisms associated with the neurological
Externí odkaz:
https://doaj.org/article/27cea76ef7de47bf89a32ecc39793a7c
Publikováno v:
Molecular Brain, Vol 16, Iss 1, Pp 1-4 (2023)
Abstract Jacob is a synapto-nuclear messenger protein that encodes and transduces the origin of synaptic and extrasynaptic NMDA receptor signals to the nucleus. The protein assembles a signalosome that differs in case of synaptic or extrasynaptic NMD
Externí odkaz:
https://doaj.org/article/f818bb40a99642d297f09ccc23c38f0e
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
GABAA receptors present in extrasynaptic areas mediate tonic inhibition in hippocampal neurons regulating the performance of neural networks. In this study, we investigated the effect of NMDA-induced plasticity on tonic inhibition in somatostatin- an
Externí odkaz:
https://doaj.org/article/ec883cc3ef3241acbc45c46405e4f872
Akademický článek
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Akademický článek
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Autor:
Raman Sankar
Publikováno v:
Epilepsia Open, Vol 8, Iss S1, Pp S141-S148 (2023)
Abstract The review presents retrospective, present views and future perspectives on the treatment of status epilepticus (SE). First, presynaptic, postsynaptic, and extrasynaptic mechanisms underlying sustaining ongoing seizure activity are highlight
Externí odkaz:
https://doaj.org/article/8d78bc281a56403da83709f0044ffc4f