Zobrazeno 1 - 10
of 8 695
pro vyhledávání: '"Extracellular signal regulated kinase"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Low fluid shear stress (FSS, ≤ 2 dyn/cm2) has been shown to exert protective effects on chondrocytes, but the underlying molecular mechanisms remain unclear. This study aimed to elucidate the mechanisms by which FSS promotes chondrocyte pr
Externí odkaz:
https://doaj.org/article/ac6933db158240cdababc1a89789f519
Publikováno v:
Journal of Orthopaedic Surgery and Research, Vol 19, Iss 1, Pp 1-13 (2024)
Abstract Objective This study investigated the protective effects of low fluid shear stress (FSS ≤ 2 dyn/cm²) against interleukin-1β (IL-1β)-induced chondrocyte apoptosis and explored the underlying molecular mechanisms. Methods Chondrocytes wer
Externí odkaz:
https://doaj.org/article/2fca0dbedc6e45dda393ce0683623e38
Publikováno v:
Zhongguo aizheng zazhi, Vol 34, Iss 7, Pp 650-658 (2024)
Background and purpose: The overexpression of carnitine palmitoyl transferase 1A (CPT1A) is related to the poor prognosis of breast cancer, and it can promote the utilization of fatty acids by mitochondria and maximize triphosphate (ATP) production.
Externí odkaz:
https://doaj.org/article/f81804f2db134bd195318e74331c6c59
Publikováno v:
Linchuang shenzangbing zazhi, Vol 24, Iss 7, Pp 536-542 (2024)
Objective To explore the expression and significance of mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway in vascular tissue of intimal hyperplasia after arteriovenous fistula (AVF) and explore the effect of
Externí odkaz:
https://doaj.org/article/5ff99402c61343e1bb632ab876c29064
Publikováno v:
Renal Failure, Vol 46, Iss 2 (2024)
Minimal change disease (MCD) is a universal primary glomerular disease contributing to nephrotic syndrome. Lon peptidase 1 (LONP1) has been suggested to protect podocytes from damage during the progression of MCD. Accordingly, our research further ex
Externí odkaz:
https://doaj.org/article/d926e08bfae6461d84297891801d0c0f
Autor:
Dan-Dan Hu, Lin Qi, Li-Tian Wang, Ya-Min Jin, Xiang-Xuan Yang, Huai-Liu Yin, Ren-Yi Zhang, Ye-Wei Huang, Jun Sheng, Xuan-Jun Wang
Publikováno v:
CyTA - Journal of Food, Vol 22, Iss 1 (2024)
Dihydrotanshinone I (DHT), a lipophilic compound extracted from Salvia miltiorrhiza, has cardiovascular protective effects, but the underlying molecular mechanisms of action have rarely been reported. Based on this, whether DHT affects cholesterol me
Externí odkaz:
https://doaj.org/article/17190395350a44f187a292b4c06a755a
Autor:
Ya-Chi Yang, Yueh Chien, Aliaksandr A. Yarmishyn, Lee-Yieng Lim, Hao-Yu Tsai, Wen-Chuan Kuo, Ping-Hsing Tsai, Sheng-Hsien Yang, Shao-I Hong, Shih-Jen Chen, De-Kuang Hwang, Yi-Ping Yang, Shih-Hwa Chiou
Publikováno v:
Journal of Advanced Research, Vol 60, Iss , Pp 141-157 (2024)
Introduction: Epithelial-mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells is related to the pathogenesis of various retinopathies including age-related macular degeneration (AMD). Oxidative stress is the major factor that induce
Externí odkaz:
https://doaj.org/article/d9aaf9dcd9f142e5bfe08fefa6711385
Autor:
Mototsugu Watanabe, Hiroko Nakai, Tatsuya Ohara, Kengo Kawasaki, Shinji Murosaki, Yoshitaka Hirose
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Heat-killed Lactiplantibacillus plantarum L-137 (HK L-137) has been suggested to enhance the intestinal barrier in obese mice, leading to improvement of metabolic abnormalities and adipose tissue inflammation, and in healthy humans with over
Externí odkaz:
https://doaj.org/article/e261d26a1bcf4eafa9b14534efe5d2ba
Publikováno v:
Biochemistry and Biophysics Reports, Vol 38, Iss , Pp 101670- (2024)
Plant homeodomain finger protein 8 (PHF8) is a histone demethylase that regulates the expression of various genes. PHF8 targets repressor histone markers and activates gene expression. Although PHF8 has been involved in X-linked mental retardation an
Externí odkaz:
https://doaj.org/article/49904e6b7e5d43568e2acee7752c0dc3
Autor:
Barbara Hausott, Lena Pircher, Michaela Kind, Jong-Whi Park, Peter Claus, Petra Obexer, Lars Klimaschewski
Publikováno v:
Cells, Vol 13, Iss 23, p 1967 (2024)
The Sprouty (SPRY) proteins are evolutionary conserved modulators of receptor tyrosine kinase (RTK) signaling. SPRY2 inhibits fibroblast growth factor (FGF) signaling, whereas it enhances epidermal growth factor (EGF) signaling through inhibition of
Externí odkaz:
https://doaj.org/article/7a01ff78ab784b5fb43dd2dd22fafc7d