Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Extracellular matrix-cell signaling"'
Publikováno v:
Blood Advances. 4:667-671
To diagnose graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is sometimes difficult. We showed previously that MEK inhibitors selectively suppress murine GVHD while retaining antiviral and antitumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc9fe64495813a453244906e14cbf4c6
https://doi.org/10.1182/bloodadvances.2019000343
https://doi.org/10.1182/bloodadvances.2019000343
Autor:
Evyn Woodhouse, Liyam Laraba, David Parkinson, Alison C. Lloyd, Charlotte Lespade, Marie Srotyr
Publikováno v:
Neuro Oncol
Aims Previous work has shown that increased numbers of macrophages are associated with more rapid schwannoma tumour growth and we are interested in signals that control entry of macrophages and other immune cells into these tumours. Activation of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dc43611f335d25ad42b3f2ea2f55f38
https://europepmc.org/articles/PMC8517855/
https://europepmc.org/articles/PMC8517855/
Autor:
Charlotte Lespade, Evyn Woodhouse, David Parkinson, Glenn M. Harper, Alison C. Lloyd, Marie Srotyr, Liyam Laraba
Publikováno v:
Neuro Oncol
Aims Our lab is interested in signals that trigger schwannoma tumour formation and we have previously shown that peripheral nerve injury triggers tumour formation in nerves with Schwann cell-specific loss of the Merlin (NF2) tumour suppressor. The Ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5371ab1367e243e4bd1ff1e4c236a1d8
https://doi.org/10.1093/neuonc/noab195.014
https://doi.org/10.1093/neuonc/noab195.014
Autor:
Emily Krzykwa, Susan N. Chi, Karen Wright, Michael D. Prados, Lianne Greenspan, Daphne A. Haas-Kogan, Kee Kiat Yeo, Sabine Mueller
Publikováno v:
Neuro Oncol
BACKGROUND We report phase I data examining pharmacokinetics, safety and preliminary efficacy of the dimeric, pan-RAF inhibitor DAY101 (formerly TAK-580/MLN2480) in pediatric patients with radiographically recurrent/progressive LGGs harboring MEK/ERK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a53d7000da52cf67daa27bd7094d43
https://europepmc.org/articles/PMC7650315/
https://europepmc.org/articles/PMC7650315/
Autor:
Serge Sultan, Édith Cantin, Marie-Élaine Métras, Uri Tabori, Yves Théorêt, Jean-Claude Décarie, Marie-Eve Routhier, Nada Jabado, Lucie Lafay-Cousin, Juliette Hukin, Eric Bouffet, Sarah Lippé, Geneviève Legault, Craig Erker, Sébastien Perreault, Maxime Caru, Valerie Larouche, Cynthia Hawkins, Benjamin Ellezam
Publikováno v:
Neuro Oncol
BACKGROUND Pediatric low-grade gliomas (PLGG) are the most frequent brain tumors in children. It is known that the majority of PLGG have activation of the MAPK/ERK pathway. METHODS This multicenter phase II included three progressing/refractory PLGG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c09468d62e77ed8da7d523d8039f80
https://europepmc.org/articles/PMC7650427/
https://europepmc.org/articles/PMC7650427/
Publikováno v:
Human molecular genetics. 29(23)
The Ras–Erk pathway is frequently overactivated in human tumors. Neurofibromatosis types 1 and 2 (NF1, NF2) are characterized by multiple tumors of Schwann cell origin. The NF1 tumor suppressor neurofibromin is a principal Ras-GAP accelerating Ras
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1305541bf49777d20fb4c29465b9c30
https://pubmed.ncbi.nlm.nih.gov/33331896
https://pubmed.ncbi.nlm.nih.gov/33331896
Autor:
Diane Platel, Sacha Flammier, Bruno Ranchin, Ségolène Gaillard, Irma Machuca-Gayet, Olivier Peyruchaud, Julie Bernardor, Justine Bacchetta
Publikováno v:
Nephrology Dialysis Transplantation. 35
Background and Aims Active vitamin D analogs and calcimimetics are cornerstones for managing secondary hyperparathyroidism (SHPT) in chronic kidney disease (CKD). Their direct effects on bone cells remain to be determined. Method Peripheral blood mon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::627bc4adfe46c78d4f26342745b43c4c
https://doi.org/10.1093/ndt/gfaa140.mo058
https://doi.org/10.1093/ndt/gfaa140.mo058
Autor:
Pan Yunzhi, Ningling Ding, Junping Cheng, Chuan-wu Zhu, Li Zhu, Runing Ji, Haiyan Wang, Sai Ma, Feng Zhou
Publikováno v:
Carcinogenesis. 42(1)
Increasing evidence suggests that liver cancer stem cells (LCSCs) are the cellular determinants that promote tumor recurrence and metastases. Aberrantly expressed miRNAs were identified in LCSCs and found to play a significant role in modulating biol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4bec7e90797019327c35a942696b4fb
https://pubmed.ncbi.nlm.nih.gov/32531042
https://pubmed.ncbi.nlm.nih.gov/32531042
Autor:
Anna Malashicheva, Alessandra Pasquali, Francesco Onorati, Olga Irtyega, Maddalena Marconi, Elisabetta Trabetti, Ilaria Pierpaola Dal Prà, Pier F Pignatti, Ubaldo Armato, Giuseppe Faggian, Cristina Patuzzo, Anna Maria Chiarini
Publikováno v:
European Journal of Preventive Cardiology. 25:51-58
BackgroundSporadic non-syndromic thoracic aortic aneurysms (SNSTAAs) are less well understood than familial non-syndromic or syndromic ones. Here, we focused on morphologic and molecular changes of the extracellular matrix of the tunica media of SNST
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9003d90bd0a5d26a8554c2fdb49499a8
https://doi.org/10.1177/2047487318759120
https://doi.org/10.1177/2047487318759120
Autor:
Raul Rabadan, Jeffrey N. Bruce, Peter A. Sims, Daniel J. Brat, Matthew R McCord, Pavan S. Upadhyayula, Andrew Gould, Hui Zhang, Gerson Rothschild, Xiaoyang Ling, Kirsten Bell Burdett, Fabio M. Iwamoto, Lee Cooper, Joseph Shilati, Rimas V. Lukas, Junfei Zhao, Cynthia Kassab, Uttiya Basu, Brice Laffleur, Wenting Zhao, Dinesh Jaishankar, Li Chen, Daniel Zhang, Peter Canoll, Robert M. Prins, Amy B. Heimberger, J. Robert Kane, Timothy F. Cloughesy, Catalina Chang, Crismita Dmello, Jared K. Burks, Craig Horbinski, Jinzhou Yuan, David Cieremans, Jonathan T. Yamaguchi, Andrew X. Chen, Roger Stupp, Christina Amidei, Víctor A. Arrieta, Bin Zhang, Adam M. Sonabend, Seong Jae Kang
Publikováno v:
Neuro-Oncology. 23:vi17-vi17
PD-1 checkpoint inhibition has led to remarkable clinical responses in several cancer types. Whereas PD-1 blockade has not shown an overall survival (OS) benefit for glioblastoma (GBM) patients, a subset of them exhibit long-term responses to this im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3dc2336f73232af4ed232db838d44d0
https://doi.org/10.1093/neuonc/noab196.062
https://doi.org/10.1093/neuonc/noab196.062