Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Extracellular loop 2"'
Autor:
Michelle Clare, Alice Rothnie, Heike Böning, Thomas Krey, Roslyn M. Bill, Ivana Milic, Andrew Devitt, Nikola Paul Chmel, Hoor Ayub
Publikováno v:
Biochimica et Biophysica Acta. Biomembranes
Tetraspanins exert a wide range of cellular functions of broad medical importance. Despite this, their biophysical characteristics are incompletely understood. Only two high-resolution structures of full-length tetraspanins have been solved. One is t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76d7f926a89bb5fd1e830f119b5c65a1
https://publications.aston.ac.uk/id/eprint/41776/1/1_s2.0_S0005273620302625_main.pdf
https://publications.aston.ac.uk/id/eprint/41776/1/1_s2.0_S0005273620302625_main.pdf
Autor:
Jeanette Woolard, Mark Soave, Stephen J. Briddon, Barrie Kellam, Martine J. Smit, Raimond Heukers, Stephen J. Hill
Publikováno v:
Cell Chemical Biology, 27(10), 1250-1261.e5. Elsevier Inc.
Cell Chemical Biology
Soave, M, Heukers, R, Kellam, B, Woolard, J, Smit, M J, Briddon, S J & Hill, S J 2020, ' Monitoring Allosteric Interactions with CXCR4 Using NanoBiT Conjugated Nanobodies ', Cell Chemical Biology, vol. 27, no. 10, pp. 1250-1261.e5 . https://doi.org/10.1016/j.chembiol.2020.06.006
Cell Chemical Biology
Soave, M, Heukers, R, Kellam, B, Woolard, J, Smit, M J, Briddon, S J & Hill, S J 2020, ' Monitoring Allosteric Interactions with CXCR4 Using NanoBiT Conjugated Nanobodies ', Cell Chemical Biology, vol. 27, no. 10, pp. 1250-1261.e5 . https://doi.org/10.1016/j.chembiol.2020.06.006
Summary Camelid single-domain antibody fragments (nanobodies) offer the specificity of an antibody in a single 15-kDa immunoglobulin domain. Their small size allows for easy genetic manipulation of the nanobody sequence to incorporate protein tags, f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a430d237ac3fb61bdf37857926f45d84
https://research.vu.nl/en/publications/022c72aa-d9dd-4a45-bf34-a7cd260dbcbb
https://research.vu.nl/en/publications/022c72aa-d9dd-4a45-bf34-a7cd260dbcbb
Publikováno v:
The Journal of Biological Chemistry
K+–Cl− cotransporters (KCCs) play important roles in physiological processes such as inhibitory neurotransmission and cell-volume regulation. KCCs exhibit significant variations in K+ affinities, yet recent atomic structures demonstrated that K+-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07147f151e4fa6fe0ca557cd9fa66e59
https://doi.org/10.1016/j.jbc.2021.100793
https://doi.org/10.1016/j.jbc.2021.100793
Autor:
Soave, Mark, Cseke, Gabriella, Hutchings, Catherine J., Brown, Alastair J.H., Woolard, Jeanette, Hill, Stephen J.
Recent interest has focused on antibodies that can discriminate between different receptor conformations. Here we have characterised the effect of a monoclonal antibody (mAb3), raised against a purified thermo-stabilised turkey ?1-adrenoceptor (?1AR-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::c1d11a4c0c43c09ee1135690f3667d84
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Mark, Soave, Gabriella, Cseke, Catherine J, Hutchings, Alastair J H, Brown, Jeanette, Woolard, Stephen J, Hill
Publikováno v:
Biochemical Pharmacology
Graphical abstract
Recent interest has focused on antibodies that can discriminate between different receptor conformations. Here we have characterised the effect of a monoclonal antibody (mAb3), raised against a purified thermo-stabilised turke
Recent interest has focused on antibodies that can discriminate between different receptor conformations. Here we have characterised the effect of a monoclonal antibody (mAb3), raised against a purified thermo-stabilised turke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::63b12cac034dba90fb7f5e28b08c1ed2
https://pubmed.ncbi.nlm.nih.gov/29102678
https://pubmed.ncbi.nlm.nih.gov/29102678
Publikováno v:
FEBS Letters. 582:2863-2868
A peptide constrained to a conformation of second extracellular loop of human prostaglandin-E(2) (PGE(2)) receptor subtype3 (hEP3) was synthesized. The contacts between the peptide residues at S211 and R214, and PGE(2) were first identified by NMR sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e7add02112124118ce4929b10ff83c2
https://doi.org/10.1016/j.febslet.2008.07.018
https://doi.org/10.1016/j.febslet.2008.07.018
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Schiedel, Anke C., Hinz, Sonja, Thimm, Dominik, Sherbiny, Farag, Borrmann, Thomas, Maaß, Astrid, Müller, Christa E.
Publikováno v:
Biochemical Pharmacology
Biochemical Pharmacology, Elsevier, 2011, 82 (4), pp.389. ⟨10.1016/j.bcp.2011.05.008⟩
Biochemical Pharmacology, Elsevier, 2011, 82 (4), pp.389. ⟨10.1016/j.bcp.2011.05.008⟩
International audience; The adenosine A receptor is of considerable interest as a new drug target for the treatment of asthma, inflammatory diseases, pain, and cancer. In the present study we investigated the role of the cysteine residues in the extr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::dcbb7fba980d4c4f59b3f538b5138670
https://hal.archives-ouvertes.fr/hal-00718035/file/PEER_stage2_10.1016%2Fj.bcp.2011.05.008.pdf
https://hal.archives-ouvertes.fr/hal-00718035/file/PEER_stage2_10.1016%2Fj.bcp.2011.05.008.pdf
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.