Chonggu Granules Improve Cartilage Matrix Metabolism in Knee Osteoarthritis via the miR-148a-3p/Wnt/β-Catenin Pathway

Autor: Cheng L, Huang C, Li M, Shang S, Chen J, Tang Z

Publikováno v: Journal of Inflammation Research, Vol Volume 16, Pp 4751-4762 (2023)

Lili Cheng,1 Chuanbing Huang,2 Ming Li,2 Shuangshuang Shang,2 Junjie Chen,1 Zhongfu Tang1 1The First Clinical Medical College, Anhui University of Traditional Chinese Medicine, Hefei, Anhui Province, 230038, People’s Republic of China; 2Department

Externí odkaz: https://doaj.org/article/662bc8a2bc484f5d8c8d21470a422f8c

The Mechanisms and Functions of GDF‐5 in Intervertebral Disc Degeneration

Autor: Sheng Guo, Liqiang Cui, Changming Xiao, Chenglong Wang, Bin Zhu, Xueli Liu, Yujie Li, Xinyue Liu, Dingxuan Wang, Sen Li

Publikováno v: Orthopaedic Surgery, Vol 13, Iss 3, Pp 734-741 (2021)

Intervertebral disc degeneration (IDD) is widely recognized as the main cause of low back pain, which leads to disability in aging populations and induces great losses both socially and economically worldwide. Unfortunately, current treatments for ID

Externí odkaz: https://doaj.org/article/0274bae8a54c44c8a13a8088be59eec0

Age-associated differences in the human lung extracellular matrix

Autor: M.L. Koloko Ngassie, M. De Vries, T. Borghuis, W. Timens, Don D. Sin, D. Nickle, P. Joubert, P. Horvatovich, G. Marko-Varga, J.J. Teske, J.M. Vonk, R. Gosens, Y.S. Prakash, J.K. Burgess, C.A. Brandsma

Publikováno v: American Journal of Physiology - Lung Cellular and Molecular Physiology. 324(6):799-814

IntroductionExtracellular matrix (ECM) remodelling has been associated with chronic lung diseases. However, information about specific age-associated differences in lung ECM is currently limited. In this study we aimed to identify and localize age-as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4486ec0619ed5676ca69dd4c11d78c9
https://research.rug.nl/en/publications/39666b6b-f667-48f7-adba-afffa8bf1432

Nampt promotes fibroblast extracellular matrix degradation in stress urinary incontinence by inhibiting autophagy

Autor: Hui Zhang, Lu Wang, Yuancui Xiang, Yali Wang, Hongjuan Li

Publikováno v: Bioengineered, Vol 13, Iss 1, Pp 481-495 (2022)
Bioengineered
article-version (VoR) Version of Record

Stress urinary incontinence (SUI) is defined as involuntary urinary leakage happening in exertion. Nicotinamide phosphoribosyltransferase (Nampt) is seldom researched in the pathogenesis of SUI. Accordingly, the current study set out to elucidate the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5845248721e26f29269ba6a1a03456a
https://doaj.org/article/b583ef714f9e41f2af4eba2d903809ed

Anastellin impacts on the processing of extracellular matrix fibronectin and stimulates release of cytokines from coronary artery smooth muscle cells

Autor: Jianfei He, Jonas Hyld Steffen, Peter Waaben Thulstrup, Jannik Nedergaard Pedersen, Max B. Sauerland, Daniel E. Otzen, Clare L. Hawkins, Pontus Gourdon, Michael J. Davies, Per Hägglund

Publikováno v: He, J, Steffen, J H, Thulstrup, P W, Pedersen, J N, Sauerland, M B, Otzen, D E, Hawkins, C L, Gourdon, P, Davies, M J & Hägglund, P 2022, ' Anastellin impacts on the processing of extracellular matrix fibronectin and stimulates release of cytokines from coronary artery smooth muscle cells ', Scientific Reports, vol. 12, no. 1, 22051 . https://doi.org/10.1038/s41598-022-26359-9

Anastellin, a recombinant protein fragment from the first type III module of fibronectin, mimics a partially unfolded intermediate implicated in the assembly of fibronectin fibrils. Anastellin influences the structure of fibronectin and initiates in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c2e3a6986e64ae6fed03c2e29c8b41b
https://pure.au.dk/portal/da/publications/anastellin-impacts-on-the-processing-of-extracellular-matrix-fibronectin-and-stimulates-release-of-cytokines-from-coronary-artery-smooth-muscle-cells(fd4aba68-64f0-4461-a77f-fba1c79a6e38).html