Nanoparticles targeting extra domain B of fibronectin-specific to the atherosclerotic lesion types III, IV, and V-enhance plaque detection and cargo delivery

Autor: Azita Lotfi, Frederick J. Schoen, Mi Kyung Yu, Omid C. Farokhzad, In-Hyun Lee, Peter Libby, Phei Er Saw, Renata Carvalho Leitao, Mirna M. B. Brayner, Jinjun Shi, Morteza Mahmoudi, Xiao-Ding Xu, Carleena Angelica Ortega, Kevin Si, Jerry Liu, Suyeon Ahn, Sangyong Jon, Roberto Molinaro

Publikováno v: Theranostics

Extra domain B of fibronectin (FN-EDB) is upregulated in the extracellular matrix during tissue remodeling and has been postulated as a potential biomarker for atherosclerosis, yet no systematic test for FN-EDB in plaques has been reported. We hypoth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a68483248b7448efbfaf174ec02b4b
https://doi.org/10.7150/thno.24365

Effect of PEG Pairing on the Efficiency of Cancer-Targeting Liposomes

Autor: Phei Er Saw, Eunbeol Lee, Jinho Park, Jinjoo Kim, Minsuk Choi, Jinju Lee, Omid C. Farokhzad, Hyungjun Kim, Sukyung Ahn, Sangyong Jon

Publikováno v: THERANOSTICS(5): 7
Theranostics

Standardized poly(ethylene glycol)-modified (PEGylated) liposomes, which have been widely used in research as well as in pre-clinical and clinical studies, are typically constructed using PEG with a molecular weight of 2000 Da (PEG(2000)). Targeting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::140767a037dbeb72433a72c06793661a
https://doi.org/10.7150/thno.10732

I-124-L19-SIP for immuno-PET imaging of tumour vasculature and guidance of I-131-L19-SIP radioimmunotherapy

Autor: C. René Leemans, Bernard M. Tijink, Marijke Stigter-van Walsum, Ludger Dinkelborg, Reina W. Kloet, Guus A.M.S. van Dongen, Gerard W. M. Visser, Lars R. Perk, Dario Neri, Marianne Budde

Publikováno v: European Journal of Nuclear Medicine and Molecular Imaging, 36(8), 1235-1244. Springer Verlag
Tijink, B M, Perk, L R, Budde, M, Stigter-van Walsum, M, Visser, G W M, Kloet, R W, Dinkelborg, L M, Leemans, C R, Neri, D & van Dongen, G A M S 2009, ' I-124-L19-SIP for immuno-PET imaging of tumour vasculature and guidance of I-131-L19-SIP radioimmunotherapy ', European Journal of Nuclear Medicine and Molecular Imaging, vol. 36, no. 8, pp. 1235-1244 . https://doi.org/10.1007/s00259-009-1096-y
European Journal of Nuclear Medicine and Molecular Imaging

The human monoclonal antibody (MAb) fragment L19-SIP is directed against extra domain B (ED-B) of fibronectin, a marker of tumour angiogenesis. A clinical radioimmunotherapy (RIT) trial with (131)I-L19-SIP was recently started. In the present study,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e286e88e7ea642f41f467f6e0a1eb053
https://doi.org/10.1007/s00259-009-1096-y

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.