Extended release promethazine HCl using acrylic polymers by freeze-drying and spray-drying techniques: formulation considerations

Autor: Gaurav Tiwari, Birendra Srivastava, Ruchi Tiwari, Awanik Rai

Publikováno v: Brazilian Journal of Pharmaceutical Sciences, Vol 45, Iss 4, Pp 829-840 (2009)
Brazilian Journal of Pharmaceutical Sciences; Vol. 45 No. 4 (2009); 829-840
Brazilian Journal of Pharmaceutical Sciences; Vol. 45 Núm. 4 (2009); 829-840
Brazilian Journal of Pharmaceutical Sciences; v. 45 n. 4 (2009); 829-840
Brazilian Journal of Pharmaceutical Sciences
Universidade de São Paulo (USP)
instacron:USP
Brazilian Journal of Pharmaceutical Sciences, Volume: 45, Issue: 4, Pages: 829-840, Published: DEC 2009

The present study investigated a novel extended release system of promethazine hydrochloride (PHC) with acrylic polymers Eudragit RL100 and Eudragit S100 in different weight ratios (1:1 and 1: 5), and in combination (0.5+1.5), using freeze-drying and

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000400029