Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells.

Autor: Haythorne E; Department of Physiology, Anatomy and Genetics and OXION, University of Oxford, Parks Road, Oxford, OX1 3PT, UK. Elizabeth.Haythorne@dpag.ox.ac.uk., Lloyd M; Department of Physiology, Anatomy and Genetics and OXION, University of Oxford, Parks Road, Oxford, OX1 3PT, UK., Walsby-Tickle J; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK., Tarasov AI; School of Biomedical Sciences, Ulster University, Coleraine, BT52 1SA, Northern Ireland, UK., Sandbrink J; Department of Physiology, Anatomy and Genetics and OXION, University of Oxford, Parks Road, Oxford, OX1 3PT, UK., Portillo I; Department of Physiology, Anatomy and Genetics and OXION, University of Oxford, Parks Road, Oxford, OX1 3PT, UK., Exposito RT; Department of Physiology, Anatomy and Genetics and OXION, University of Oxford, Parks Road, Oxford, OX1 3PT, UK.; Institute for Diabetes and Cancer (IDC), Helmholtz Center, Munich, Neuherberg, 85764, Germany., Sachse G; Department of Physiology, Anatomy and Genetics and OXION, University of Oxford, Parks Road, Oxford, OX1 3PT, UK.; Brandenburg Medical School (Theodor Fontane), ZTM-BB, Brandenburg a. d. H, 14770, Germany., Cyranka M; Department of Physiology, Anatomy and Genetics and OXION, University of Oxford, Parks Road, Oxford, OX1 3PT, UK., Rohm M; Department of Physiology, Anatomy and Genetics and OXION, University of Oxford, Parks Road, Oxford, OX1 3PT, UK.; Institute for Diabetes and Cancer (IDC), Helmholtz Center, Munich, Neuherberg, 85764, Germany., Rorsman P; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK., McCullagh J; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK., Ashcroft FM; Department of Physiology, Anatomy and Genetics and OXION, University of Oxford, Parks Road, Oxford, OX1 3PT, UK. frances.ashcroft@dpag.ox.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2022 Nov 14; Vol. 13 (1), pp. 6754. Date of Electronic Publication: 2022 Nov 14.

Metabolism as a central regulator of β‐cell chromatin state.

Autor: Vanderkruk, Ben^1,2,3 (AUTHOR), Hoffman, Brad G.^1,2,3 (AUTHOR) brad.hoffman@ubc.ca

Publikováno v: FEBS Journal. Jun2021, Vol. 288 Issue 12, p3683-3693. 11p.