A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strain

Autor: Samira Alliouachene, Jianmin Chen, Julius Kieswich, Muhammad M. Yaqoob, Christoph Thiemermann, Kieran McCafferty, Paul W. Caton

Publikováno v: BMC Nephrology, Vol 19, Iss 1, Pp 1-12 (2018)
BMC Nephrology

Background The end stage renal disease population has a 20 fold higher incidence of cardiovascular mortality compared to the overall population. The development of reno-cardiac syndrome in these patients will result in cardiovascular events to be the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f01f5cec4f2e72ac7100e6044a329d45
https://doi.org/10.1186/s12882-018-1155-3

Epidermal growth factor receptor inhibitor PKI-166 governs cardiovascular protection without beneficial effects on the kidney in hypertensive 5/6 nephrectomized rats

Autor: Gemma M. Mulder, Nadir Ulu, Sjoerd W. Landheer, Maaike Goris, Hakan Gurdal, Robert H. Henning, Basak Duman-Dalkilic, Hendrik Buikema, M Duin, Richard P. E. van Dokkum, Harry van Goor, Peter Vavrinec

Publikováno v: Journal of Pharmacology and Experimental Therapeutics, 345(3), 393-403. WILLIAMS & WILKINS

Transactivation of epidermal growth factor receptor (EGFR) signaling by G protein-coupled receptors has been implicated in several cardiovascular (CV) conditions, including hypertension, heart failure, and cardiac and vascular hypertrophy. However, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::519590fdc5fa6d86f3fd770d068d6479
https://doi.org/10.1124/jpet.113.203497

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Proteinuria-associated endothelial dysfunction Is strain dependent

Autor: Tom Teerlink, Freek J. Zijlstra, Nadir Ulu, Wiek H. van Gilst, Stephan J. L. Bakker, Robert H. Henning, Gerjan Navis, Regien G. Schoemaker, Hendrik Buikema

Publikováno v: American Journal of Nephrology, 30(3), 209-217. S. Karger AG
American Journal of Nephrology, 30(3), 209-217. KARGER
Ulu, N, Schoemaker, R G, Henning, R H, Buikema, H, Teerlink, T, Zijlstra, F, Bakker, S J L, van Gilst, W H & Navis, G 2009, ' Proteinuria-associated endothelial dysfunction Is strain dependent ', American Journal of Nephrology, vol. 30, no. 3, pp. 209-217 . https://doi.org/10.1159/000218062

Background: Proteinuria-associated endothelial dysfunction (ED) is assumed to play a main role in the cardiovascular morbidity in proteinuric patients. However, the connection between proteinuria and systemic endothelial function is not clear yet. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec1cc14a018ce9aac0c4baaeb852aff5
https://research.vumc.nl/en/publications/b3fcaace-cd92-43e2-99d4-0d95534a4f68

A novel model of adenine-induced tubulointerstitial nephropathy in mice

Autor: Ting Jia, Göran Andersson, Bengt Lindholm, Karin Edvardsson, Annika Wernerson, Tobias E. Larsson, Yves Sabbagh, Risul Amin, Susan C. Schiavi, Hannes Olauson, Karolina Lindberg

Publikováno v: BMC Nephrology

Background In vivo models of uremia are important tools to study numerous aspects of acute and chronic kidney disease. Mouse models are pivotal because most genetically engineered animal models are mice, which allow dissecting the impact of selected

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::251aefb362188f205b5ca9e6e6788a57
http://europepmc.org/articles/PMC3682934