Zobrazeno 1 - 10
of 676
pro vyhledávání: '"Experimental models of disease"'
Autor:
Völkner, Manuela, Wagner, Felix, Steinheuer, Lisa Maria, Carido, Madalena, Kurth, Thomas, Yazbeck, Ali, Schor, Jana, Wieneke, Stephanie, Ebner, Lynn J. A., Runzer, Claudia Del Toro, Taborsky, David, Zoschke, Katja, Vogt, Marlen, Canzler, Sebastian, Hermann, Andreas, Khattak, Shahryar, Hackermüller, Jörg, Karl, Mike O.
Human organoids could facilitate research of complex and currently incurable neuropathologies, such as age-related macular degeneration (AMD) which causes blindness. Here, we establish a human retinal organoid system reproducing several parameters of
Externí odkaz:
https://tud.qucosa.de/id/qucosa%3A89844
https://tud.qucosa.de/api/qucosa%3A89844/attachment/ATT-0/
https://tud.qucosa.de/api/qucosa%3A89844/attachment/ATT-0/
Autor:
Karin Dijkman, Richard A. W. Vervenne, Claudia C. Sombroek, Charelle Boot, Sam O. Hofman, Krista E. van Meijgaarden, Tom H. M. Ottenhoff, Clemens H. M. Kocken, Krista G. Haanstra, Michel P. M. Vierboom, Frank A. W. Verreck
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
While tuberculosis continues to afflict mankind, the immunological mechanisms underlying TB disease development are still incompletely understood. Advanced preclinical models for TB research include both rhesus and cynomolgus macaques (Macaca mulatta
Externí odkaz:
https://doaj.org/article/60dd21741d194b77915749c68bee85a6
Autor:
María Páramo, Eva Santamaría, Miguel A. Idoate, Macarena Rodríguez-Fraile, Alberto Benito, Maria Collantes, Gemma Quincoces, Iván Peñuelas, Carmen Berasain, Josepmaria Argemi, Jorge Quiroga, Bruno Sangro, José I. Bilbao, Mercedes Iñarrairaegui
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Scientific Reports
Scientific Reports
Lobar selective internal radiation therapy (SIRT) is widely used to treat liver tumors inducing atrophy of the treated lobe and contralateral hypertrophy. The lack of animal model has precluded further investigations to improve this treatment. We dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::928f954f72c54b9dc95e884f55c2544c
https://doaj.org/article/9b8adb35808e471683505cf5bacd215d
https://doaj.org/article/9b8adb35808e471683505cf5bacd215d
Autor:
Alycia G. Berman, Daniel J. Romary, Katherine E. Kerr, Natalyn E. Gorazd, Morgan M. Wigand, Sourav S. Patnaik, Ender A. Finol, Abigail D. Cox, Craig J. Goergen
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Scientific Reports
Scientific Reports
Abdominal aortic aneurysm (AAA) formation and expansion is highly complex and multifactorial, and the improvement of animal models is an important step to enhance our understanding of AAA pathophysiology. In this study, we explore our ability to infl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ff1700bc04130583ee6c33368893b33
https://doaj.org/article/58bb105c53454f0aab1b07f8e032f186
https://doaj.org/article/58bb105c53454f0aab1b07f8e032f186
Autor:
Tomoya, Soma, Ryotaro, Iwasaki, Yuiko, Sato, Tami, Kobayashi, Eri, Ito, Tatsuaki, Matsumoto, Atsushi, Kimura, Kana, Miyamoto, Morio, Matsumoto, Masaya, Nakamura, Mayu, Morita, Seiji, Asoda, Hiromasa, Kawana, Taneaki, Nakagawa, Takeshi, Miyamoto
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Scientific Reports
Scientific Reports
Invasive dental treatment such as tooth extraction following treatment with strong anti-bone resorptive agents, including bisphosphonates and denosumab, reportedly promotes osteonecrosis of the jaw (ONJ) at the extraction site, but strategies to prev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f5b58b23dcd573b53fd95a256d3f556
https://doaj.org/article/ce6fd803db684c4ebfcc0c4e761a4f2f
https://doaj.org/article/ce6fd803db684c4ebfcc0c4e761a4f2f
Autor:
Angelique Wolter, Christian H. Bucher, Sebastian Kurmies, Viktoria Schreiner, Frank Konietschke, Katharina Hohlbaum, Robert Klopfleisch, Max Löhning, Christa Thöne-Reineke, Frank Buttgereit, Jörg Huwyler, Paulin Jirkof, Anna E. Rapp, Annemarie Lang
Adequate pain management is essential for ethical and scientific reasons in animal experiments and should completely cover the period of expected pain without the need for frequent re-application. However, current depot formulations of Buprenorphine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf4ef48009816f3561147b9849a581c0
https://refubium.fu-berlin.de/handle/fub188/38831
https://refubium.fu-berlin.de/handle/fub188/38831
Publikováno v:
Experimental & Molecular Medicine
Caspase-2 was discovered almost three decades ago. It was one of the first two mammalian homologs of CED-3, the other being interleukin 1β-converting enzyme (ICE/caspase-1). Despite high similarity with CED-3 and its fly and mammalian counterparts (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ecba0868924a9a39d19b627ffcde23a
https://doi.org/10.1038/s12276-021-00590-2
https://doi.org/10.1038/s12276-021-00590-2
Autor:
Robert Patejdl, Felix Klawitter, Uwe Walter, Karim Zanaty, Frank Schwandner, Tina Sellmann, Katrin Porath, Johannes Ehler
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Patients suffering from critical illness are at risk to develop critical illness neuromyopathy (CINM). The underlying pathophysiology is complex and controversial. A central question is whether soluble serum factors are involved in the pathogenesis o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4fdb387672ab683eb5813231b9809b4
https://doaj.org/article/d9fce5aeb29743788f7686e522874e14
https://doaj.org/article/d9fce5aeb29743788f7686e522874e14
Autor:
Liying Tang, Xiao Zhang, Lixia Wang, Yaqi Lu, Xiankuo Yu, Hanyan Luo, Cong Liu, Hongwei Wu, Shuiming Xiao, Zhuju Wang
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Communications Biology
Communications Biology
Cassiae Semen (CS), the seeds of Cassia obtusifolia L. and C. tora L, have a long medicinal history in China, with suggestions for it to relieve constipation and exert hepatoprotective effects. However, the underlying mechanisms are still unclear. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::822881059032383de8b735a126a803f8
https://doaj.org/article/751ca22369664970a69dc151bdf0d922
https://doaj.org/article/751ca22369664970a69dc151bdf0d922
Publikováno v:
npj Regenerative Medicine, Vol 6, Iss 1, Pp 1-12 (2021)
NPJ Regenerative Medicine
NPJ Regenerative Medicine
Chronic non-healing wounds, frequently caused by diabetes, lead to lower quality of life, infection, and amputation. These wounds have limited treatment options. We have previously engineered growth factors to bind to exposed extracellular matrix (EC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b101510e2f190fb0dd7e1997966ec674
https://doaj.org/article/c930dc77d1ca49068331a5f7d4510f03
https://doaj.org/article/c930dc77d1ca49068331a5f7d4510f03