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pro vyhledávání: '"Experimental Research Articles"'
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Publikováno v:
The Korean Journal of Pain
Background We aimed to investigate the effect of epidural polydeoxyribonucleotide (PDRN) on mechanical allodynia and motor dysfunction in a rat model of lumbar foraminal stenosis (LFS). Methods This study was conducted in two stages, using male Sprag
Publikováno v:
The Korean Journal of Pain
Background: Transient receptor potential vanilloid 1 (TRPV1) is a non-selective cation channel implicated in pain sensation in response to heat, protons, and capsaicin (CAPS). It is well established that TRPV1 is involved in mechanical allodynia. Thi
Publikováno v:
The Korean Journal of Pain
Background Diabetes-related neuropathic pain frequently occurs, and the underpinning mechanism remains elusive. The periaqueductal gray (PAG) exhibits descending inhibitory effects on central pain transmission. The current work aimed to examine wheth
Publikováno v:
The Korean Journal of Pain
Background Management of pain from open wounds is a growing unmet healthcare need. However, the models available to study pain from wounds or to develop analgesics for the patients suffering from them have primarily relied on incisional models. Here,
Publikováno v:
The Korean Journal of Pain
Background: It is known that some analgesics as well as pain can affect the immune system. The aim of this study was to investigate the analgesic effect and immunomodulation of pregabalin (PGB) in a mouse incisional pain model. Methods: A postoperati
Autor:
Yaqun Li, Jeong Il Choi, Hyung Gon Lee, Seung Hoon Kim, Dong Ho Kang, Hyun Eung You, Myung Ha Yoon, Woong Mo Kim
Publikováno v:
The Korean Journal of Pain
Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a major reason for stopping or changing anticancer therapy. Among the proposed pathomecha-nisms underlying CIPN, proinflammatory processes have attracted increasing attention. Here we a
Publikováno v:
The Korean Journal of Pain
Background: The present investigation explored the therapeutic actions of oleuropein along with the possible signaling pathway involved in attenuating neuropathic pain in chronic constriction injury (CCI) and vincristine-induced neuropathic pain in m
Autor:
Jin Soo Ko, Yong Hun Jung, Jae Hyuk Do, Young Cheol Woo, Hyun Kang, Jun Mo Lee, Geun Joo Choi, Chong Wha Baek
Publikováno v:
The Korean Journal of Pain
Background In this study, we sought to evaluate whether systemic propentofylline (PPF) has antiallodynic effects in a rat model of postoperative pain, and to assess the mechanism involved. Methods After plantar incision, rats were intraperitoneally i
Publikováno v:
The Korean Journal of Pain
Background Chemotherapy-induced peripheral neuropathy (CIPN) is a major side effect of anti-cancer drugs. Neurotensin receptors (NTSRs) are widely distributed within the pain circuits in the central nervous system. The purpose of this study was to de