Zobrazeno 1 - 10
of 472
pro vyhledávání: '"Experimental Drug"'
Publikováno v:
Clinical and Biomedical Research, Vol 43, Iss 3 (2023)
Centros de pesquisa clínica são estabelecimentos de saúde que possuem capacidade de conduzir estudos clínicos em medicamentos experimentais. Essa atuação é realizada em conformidade com a legislação do órgão regulador de cada país e com o
Externí odkaz:
https://doaj.org/article/9d60a5143a7a4f2c8df0969d82777a71
Publikováno v:
Frontiers in Public Health, Vol 10 (2022)
BackgroundDrug use among adolescents are still crucial issues that endanger their lifetime health. Evidence concerning the interpersonal-related factors influencing youngsters' experimental drug use behavior, especially from longitudinal and school-b
Externí odkaz:
https://doaj.org/article/d6f13996ca61482e808128444802cf8e
Autor:
Solenne, Vigne, Donovan, Duc, Benjamin, Peter, Jessica, Rebeaud, Yannick, Yersin, Florian, Ruiz, Valentine, Bressoud, Tinh-Hai, Collet, Caroline, Pot
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-12 (2022)
Journal of neuroinflammation, vol. 19, no. 1, pp. 42
Journal of neuroinflammation, vol. 19, no. 1, pp. 42
Background Multiple sclerosis (MS) is a chronic disabling disease of the central nervous system (CNS) commonly affecting young adults. There is increasing evidence that environmental factors are important in the development and course of MS. The meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c7ec1971c1b3566d492b09b7623067aa
https://doaj.org/article/bcf2ff87b9074735a9b5e0413603412d
https://doaj.org/article/bcf2ff87b9074735a9b5e0413603412d
Autor:
Morwena J. Solivio, Alessia Stornetta, Julie Gilissen, Peter W. Villalta, Sofie Deschoemaeker, Arne Heyerick, Ludwig Dubois, Silvia Balbo
Publikováno v:
Chemical Research in Toxicology, 35(2), 275-282. American Chemical Society
Many chemotherapeutic drugs exert their cytotoxicity through the formation of DNA modifications (adducts), which interfere with DNA replication, an overactive process in rapidly dividing cancer cells. Side effects from the therapy are common, however
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff84922cf533120ef66599dbfa0717e8
https://doi.org/10.1021/acs.chemrestox.1c00329
https://doi.org/10.1021/acs.chemrestox.1c00329
Publikováno v:
ACS Omega
ACS Omega, Vol 6, Iss 42, Pp 28366-28372 (2021)
ACS Omega, Vol 6, Iss 42, Pp 28366-28372 (2021)
Molnupiravir (MK-4482, EIDD-2801) is an experimental drug that has been demonstrated to be effective for the treatment of COVID-19 in human clinical trials. Herein, we report a concise synthesis of the drug via a novel thionated derivative that relie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1f27432f107d2ac0a42bccb417bdee4
http://europepmc.org/articles/PMC8552467
http://europepmc.org/articles/PMC8552467
Publikováno v:
Journal of Experimental Pharmacology
JOURNAL OF EXPERIMENTAL PHARMACOLOGY
JOURNAL OF EXPERIMENTAL PHARMACOLOGY
Marfan syndrome (MFS) is a heritable connective tissue disorder caused by pathogenic variants in the gene coding for the extracellular matrix protein fibrillin-1. While the disease affects multiple organ systems, the most life-threatening manifestati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37609031a7bfed43c9dc23c0ab6c76d3
https://doi.org/10.2147/jep.s265271
https://doi.org/10.2147/jep.s265271
Publikováno v:
Ukrainian Journal of Veterinary and Agricultural Sciences, Vol 4, Iss 2, Pp 52-57 (2021)
The article presents data on the effectiveness of new domestic antiparasitic drug “Insectostop for dogs and cats” in comparison to the reference drugs “Burdi Fipro for dogs” and “Burdi Fipro for cats” that is used for therapeutic and prop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86af3f4ba5c1dbb1fb07d08658e8f75f
https://ujvas.com.ua/index.php/journal/article/view/91
https://ujvas.com.ua/index.php/journal/article/view/91
Publikováno v:
Journal of Medicinal Chemistry. 64:10621-10640
MDM4 is a homologue of MDM2, serving cooperatively as the negative regulator of tumor suppressor p53. Under the shadow of MDM2 inhibitors, limited efforts had been put into the discovery of MDM4 modulators. Recent studies of the experimental drug ALR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fa5899d02c80813b8de613ff8f2f295
https://doi.org/10.1021/acs.jmedchem.1c00940
https://doi.org/10.1021/acs.jmedchem.1c00940
Publikováno v:
Damgaard, M V, Jepsen, S L, Ashcroft, S P, Holst, J J & Treebak, J T 2022, ' Pterostilbene Fails to Rescue Insulin Secretion and Sensitivity in Multiple Murine Models of Diabetes ', Nutrients, vol. 14, no. 18, 3741 . https://doi.org/10.3390/nu14183741
Nutrients; Volume 14; Issue 18; Pages: 3741
Nutrients; Volume 14; Issue 18; Pages: 3741
Diabetes incidence is rising globally at an accelerating rate causing issues at both the individual and societal levels. However, partly inspired by Ayurvedic medicine, a naturally occurring compound called pterostilbene has been demonstrated to prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd22c4db72393b3ba761b32f25694d7
https://pubmed.ncbi.nlm.nih.gov/36145121
https://pubmed.ncbi.nlm.nih.gov/36145121
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 40:6603-6618
Repurposing of antivirals is an attractive therapeutic option for the treatment of COVID-19. Main protease (Mpro), also called 3 C-like protease (3CLpro) is a key protease of SARS-CoV-2 involved in viral replication, and is a promising drug target fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0686505f34972bd8ba58e7ac0ff0d480
https://doi.org/10.1080/07391102.2021.1891141
https://doi.org/10.1080/07391102.2021.1891141