Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Exocytosis/physiology"'
Autor:
Padamsey, Zahid, McGuinness, Lindsay, Bardo, Scott J., Reinhart, Marcia, Tong, Rudi, Hedegaard, Anne, Hart, Michael L., Emptage, Nigel J.
Publikováno v:
Padamsey, Z, McGuinness, L, Bardo, S J, Reinhart, M, Tong, R, Hedegaard, A, Hart, M L & Emptage, N J 2017, ' Activity-Dependent Exocytosis of Lysosomes Regulates the Structural Plasticity of Dendritic Spines ', Neuron, vol. 93, no. 1, pp. 132-146 . https://doi.org/10.1016/j.neuron.2016.11.013
Lysosomes have traditionally been viewed as degradative organelles, although a growing body of evidence suggests that they can function as Ca2+ stores. Here we examined the function of these stores in hippocampal pyramidal neurons. We found that back
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::05e00eaf185c3f01b546c041c8c7d96b
https://www.pure.ed.ac.uk/ws/files/138858385/Padamsey_Z_Activity_Dependent_Exocytosis....pdf
https://www.pure.ed.ac.uk/ws/files/138858385/Padamsey_Z_Activity_Dependent_Exocytosis....pdf
Autor:
Pedro Luis Herrera, Negar Karimian, Patrick Gilon, Ya-Chi Huang, Marjan Slak Rupnik, Herbert Y. Gaisano, Zhong-Ping Feng
Publikováno v:
Diabetes, Vol. 62, No 2 (2013) pp. 519-30
Diabetes
Diabetes
Early-stage type 1 diabetes (T1D) exhibits hyperglucagonemia by undefined cellular mechanisms. Here we characterized α-cell voltage-gated ion channels in a streptozotocin (STZ)-induced diabetes model that lead to increased glucagon secretion mimicki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e727c3b39f6a958ed5b2b4a66898554
https://doi.org/10.2337/db11-0786
https://doi.org/10.2337/db11-0786
Autor:
Reinhard Jahn, Dirk Fasshauer
Publikováno v:
Nature
Nature, vol. 490, no. 7419, pp. 201-207
Nature, vol. 490, no. 7419, pp. 201-207
Calcium-dependent exocytosis of synaptic vesicles mediates the release of neurotransmitters. Important proteins in this process have been identified such as the SNAREs, synaptotagmins, complexins, Munc18 and Munc13. Structural and functional studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfc690028bd6bd724305ed21d1f4e561
Autor:
Iglesias José, Barg Sebastian, Vallois David, Lahiri Shawon, Roger Catherine, Yessoufou Akadiri, Pradevand Sylvain, McDonald Angela, Bonal Claire, Reimann Frank, Gribble Fiona, Debril Marie Bernard, Metzger Daniel, Chambon Pierre, Herrera Pedro, Rutter Guy A., Prentki Marc, Thorens Bernard, Wahli Walter
Publikováno v:
The Journal of clinical investigation
Journal of Clinical Investigation, Vol. 122, No 11 (2012) pp. 4105-17
Journal of Clinical Investigation
Journal of Clinical Investigation, Vol. 122, No 11 (2012) pp. 4105-17
Journal of Clinical Investigation
PPARβ/δ protects against obesity by reducing dyslipidemia and insulin resistance via effects in muscle, adipose tissue, and liver. However, its function in pancreas remains ill defined. To gain insight into its hypothesized role in β cell function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d320ba819c1297d8242136e012303cc
Autor:
Claes B. Wollheim, Benoit R. Gauthier
Publikováno v:
Médecine/Sciences, Vol. 22, No 5 (2006) pp. 463-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7af07f72d41c19d3b1958bdfa167031f
https://doi.org/10.1051/medsci/2006225463
https://doi.org/10.1051/medsci/2006225463
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32282 (2012)
PLoS ONE, 2012, 7(3), e32282
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
PloS one, 7 (3
PLoS ONE
PLoS ONE, 2012, 7(3), e32282
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
PloS one, 7 (3
PLoS ONE
Glucagon hormone is synthesized and released by pancreatic α-cells, one of the islet-cell types. This hormone, along with insulin, maintains blood glucose levels within the physiological range. Glucose stimulates glucagon release at low concentratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::244f15600738eb190c5cc51fdd8518c0
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22412861/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22412861/?tool=EBI
Publikováno v:
The Journal of Cell Biology
Journal of Cell Biology, vol. 188, no. 3, pp. 401-413
Journal of Cell Biology, vol. 188, no. 3, pp. 401-413
Time-resolved measurements of exocytosis identify a domain of the SNARE complex required to keep vesicles readily releasable.
Rapid neurotransmitter release depends on the ability to arrest the SNAP receptor (SNARE)–dependent exocytosis pathwa
Rapid neurotransmitter release depends on the ability to arrest the SNAP receptor (SNARE)–dependent exocytosis pathwa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ef744d749eaa66b8abfffbf62db3c61
Publikováno v:
Mass Spectrometry Reviews, Vol. 28, No 5 (2009) pp. 844-867
Regulated secretory organelles are important subcellular structures of living cells that allow the release in the extracellular space of crucial compounds, such as hormones and neurotransmitters. Therefore, the regulation of biogenesis, trafficking,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1400::e97ce8bd99706419a594f7ad6ac4467c
https://archive-ouverte.unige.ch/unige:19712
https://archive-ouverte.unige.ch/unige:19712
Autor:
Yves Benoît Mattenberger, Kyu Sang Park, Piero Marchetti, Andreas Wiederkehr, Jean-Claude Martinou, Clare L. Kirkpatrick, Nicolas Demaurex, Claes B. Wollheim
Publikováno v:
Journal of Biological Chemistry, Vol. 283, No 48 (2008) pp. 33347-56
Mitochondria form filamentous networks that undergo continuous fission/fusion. In the pancreatic β-cells, mitochondria are essential for the transduction of signals linking nutrient metabolism to insulin granule exocytosis. Here we have studied mito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a957684c2f41402177f10d43d1a4370
https://pubmed.ncbi.nlm.nih.gov/18832378
https://pubmed.ncbi.nlm.nih.gov/18832378
Autor:
Benoit R. Gauthier, Claes B. Wollheim
Publikováno v:
American Journal of Physiology. Endocrinology and Metabolism, Vol. 295, No 6 (2008) pp. E1279-86
Plasma insulin levels are determined mainly by the rate of exocytosis of the insulin-containing large dense core vesicles (LDCVs) of pancreatic islet β-cells. This process involves the recruitment of LDCVs to the plasma membrane, where they are dock
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65ebce12fc03141e300632feb9c03d16
https://pubmed.ncbi.nlm.nih.gov/18713958
https://pubmed.ncbi.nlm.nih.gov/18713958