Fluoxetine ameliorates mucopolysaccharidosis type IIIA

Autor: Antonella Capuozzo, Sandro Montefusco, Vincenzo Cacace, Martina Sofia, Alessandra Esposito, Gennaro Napolitano, Eduardo Nusco, Elena Polishchuk, Maria Teresa Pizzo, Maria De Risi, Elvira De Leonibus, Nicolina Cristina Sorrentino, Diego Luis Medina

Publikováno v: Mol Ther

Mucopolysaccharidosis type IIIA (MPS-IIIA) is an autosomal recessive disorder caused by mutations in SGSH involved in the degradation of heparan sulfate. MPS-IIIA presents severe neurological symptoms such as progressive developmental delay and cogni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac3f587c91126773c40abf800d88d65d
https://doi.org/10.1016/j.ymthe.2022.01.037

Elastocytosis

Autor: Gaetano Napoli, Alain Goriely

Endocytosis and exocytosis are key mechanisms in cellular systems by which a cell deforms its plasma membrane to move substances in or out of the cell. Whereas these cellular processes typically rely on active mechanisms, we study here the problem of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f766c9be9ca4dce4b667d729b8517be
https://doi.org/10.1016/j.jmps.2020.104133

Melatonin affects the motility and adhesiveness of in vitro capacitated boar spermatozoa via a mechanism that does not depend on intracellular ROS levels

Autor: Martina Rocco, Teresa Rigau, Teresa Muiño-Blanco, Adriana Casao, Marcella Spinaci, Rafael Pedroso Betarelli, Josep M. Fernández-Novell, Anna Placci, Joan E. Rodríguez-Gil, José A Cebrián-Pérez, A Peña, Miriam Castillo-Martín, Sergi Bonet, Marc Yeste

Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Zaguán. Repositorio Digital de la Universidad de Zaragoza
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)

This work sought to address the effects of melatonin during invitro capacitation (IVC) and progesterone-induced acrosome exocytosis (IVAE) in boar spermatozoa. With this purpose, two different experiments were set. In the first one, IVC and IVAE were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35efe6410a423e2cab20540762c08c49
http://zaguan.unizar.es/record/78944

Mutations in the Neuronal Vesicular SNARE VAMP2 Affect Synaptic Membrane Fusion and Impair Human Neurodevelopment

Autor: Salpietro, Vincenzo, Malintan, Nancy T, Llano-Rivas, Isabel, Spaeth, Christine G, Efthymiou, Stephanie, Striano, Pasquale, Vandrovcova, Jana, Cutrupi, Maria C, Chimenz, Roberto, David, Emanuele, Di Rosa, Gabriella, Marce-Grau, Anna, Raspall-Chaure, Miquel, Martin-Hernandez, Elena, Zara, Federico, Minetti, Carlo, Bello, Oscar D, De Zorzi, Rita, Fortuna, Sara, Dauber, Andrew, Alkhawaja, Mariam, Sultan, Tipu, Mankad, Kshitij, Vitobello, Antonio, Thomas, Quentin, Mau-Them, Frederic Tran, Faivre, Laurence, Martinez-Azorin, Francisco, Prada, Carlos E, Macaya, Alfons, Kullmann, Dimitri M, Rothman, James E, Krishnakumar, Shyam S, Houlden, Henry, Kriouile, Yamna, El Khorassani, Mohamed, Aguennouz, Mhammed, Karashova, Blagovesta, Avdjieva, Daniela, Kathom, Hadil, Tincheva, Radka, Van Maldergem, Lionel, Nachbauer, Wolfgang, Boesch, Sylvia, Arning, Larissa, Timmann, Dagmar, Cormand, Bru, Pérez-Dueñas, Belen, Pironti, Erica, Goraya, Jatinder S, Kirmani, Salman, Ibrahim, Shahnaz, Jan, Farida, Mine, Jun, Banu, Selina, Veggiotti, Pierangelo, Ferrari, Michel D, Verrotti, Alberto, Marseglia, Gian Luigi, Savasta, Salvatore, Garavaglia, Barbara, Scuderi, Carmela, Borgione, Eugenia, Dipasquale, Valeria, Cutrupi, Maria Concetta, Portaro, Simona, Sanchez, Benigno Monteagudo, Pineda-Marfa’, Mercedes, Munell, Francina, Boles, Richard, Heimer, Gali, Papacostas, Savvas, Manole, Andreea, Malintan, Nancy, Zanetti, Maria Natalia, Hanna, Michael G, Houlden, Henry.

Publikováno v: American Journal of Human Genetics

VAMP2 encodes the vesicular SNARE protein VAMP2 (also called synaptobrevin-2). Together with its partners syntaxin-1A and synaptosomal-associated protein 25 (SNAP25), VAMP2 mediates fusion of synaptic vesicles to release neurotransmitters. VAMP2 is e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::16e847325e2274e0b21469ce2adde331
http://hdl.handle.net/11368/2945858

MID2 can substitute for MID1 and control exocytosis of lytic granules in cytotoxic T cells

Autor: Trine B. Levring, Carsten Geisler, Germana Meroni, Lasse Boding, Ann Kathrine Hansen, Niels Ødum, Charlotte M. Bonefeld, Anders Woetmann

Publikováno v: APMIS. 123:682-687

We have recently shown that the E3 ubiquitin ligase midline 1 (MID1) is upregulated in murine cytotoxic lymphocytes (CTL), where it controls exocytosis of lytic granules and the killing capacity. Accordingly, CTL from MID1 knock-out (MID1(-/-)) mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6bef4c0b1c084c276d353c874a1f5c0
https://doi.org/10.1111/apm.12402