Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Exequiel Barrera"'
Autor:
Andrea Medeiros, Diego Benítez, Ricarda S. Korn, Vinicius C. Ferreira, Exequiel Barrera, Federico Carrión, Otto Pritsch, Sergio Pantano, Conrad Kunick, Camila I. de Oliveira, Oliver C. F. Orban, Marcelo A. Comini
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1345-1358 (2020)
Trypanothione synthetase (TryS) produces N1,N8-bis(glutathionyl)spermidine (or trypanothione) at the expense of ATP. Trypanothione is a metabolite unique and essential for survival and drug-resistance of trypanosomatid parasites. In this study, we re
Externí odkaz:
https://doaj.org/article/c7e8b72ceda647528cd31f98709c09d0
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Externí odkaz:
https://doaj.org/article/83b4e849233b4f67bc2c146d4574d2ae
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Helminths use an alternative mitochondrial electron transport chain (ETC) under hypoxic conditions, such as those found in the gastrointestinal tract. In this alternative ETC, fumarate is the final electron acceptor and rhodoquinone (RQ) serves as an
Externí odkaz:
https://doaj.org/article/9bce135c9f23441e8ffdc1ad3ef61485
Autor:
María Florencia Gómez Castro, Emanuel Miculán, María Georgina Herrera, Carolina Ruera, Federico Perez, Eduardo Daniel Prieto, Exequiel Barrera, Sergio Pantano, Paula Carasi, Fernando Gabriel Chirdo
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Celiac disease (CD) is a chronic enteropathy elicited by a Th1 response to gluten peptides in the small intestine of genetically susceptible individuals. However, it remains unclear what drives the induction of inflammatory responses of this kind aga
Externí odkaz:
https://doaj.org/article/dd4610d4590d461f92febaa06dfcdc75
Publikováno v:
Journal of Chemical Information and Modeling. 60:964-973
Post-translational modifications (PTMs) on proteins significantly enlarge the physicochemical diversity present in biological macromolecules, altering function, localization, and interactions. Despite their critical role in regulating cellular proces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::041501a15e5276caeac38245cac0cb85
https://doi.org/10.1021/acs.jcim.9b00900
https://doi.org/10.1021/acs.jcim.9b00900
Publikováno v:
Biochimica et biophysica acta. Biomembranes. 1864(1)
Protein-lipid interactions modulate a plethora of physiopathologic processes and have been the subject of countless studies. However, these kinds of interactions in the context of viral envelopes have remained relatively unexplored, partially because
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f46227eeda34dd0cebb2044084240b
https://pubmed.ncbi.nlm.nih.gov/34656553
https://pubmed.ncbi.nlm.nih.gov/34656553
Autor:
Martín Soñora, Florencia Klein, Steffano Silva, Exequiel Barrera, Sergio Pantano, Matías R. Machado
Publikováno v:
Journal of Chemical Theory and Computation. 15:2719-2733
A new version of the coarse-grained (CG) SIRAH force field for proteins has been developed. Modifications to bonded and non-bonded interactions on the existing molecular topologies significantly ameliorate the structural description and flexibility o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b867bdf626b3e1fb8d159ebb4e834e
https://doi.org/10.1021/acs.jctc.9b00006
https://doi.org/10.1021/acs.jctc.9b00006
Publikováno v:
Journal of chemical theory and computation. 17(2)
The challenges posed by intrinsically disordered proteins (IDPs) to atomistic and coarse-grained (CG) simulations are boosting efforts to develop and reparametrize current force fields. An assessment of the dynamical behavior of IDPs' and unstructure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2327c25fa8a3800b189febd20ef5874
https://pubmed.ncbi.nlm.nih.gov/33411518
https://pubmed.ncbi.nlm.nih.gov/33411518
Autor:
Pablo Garay, Matías R. Machado, Martín Soñora, Florencia Klein, Sergio Pantano, Exequiel Barrera
Publikováno v:
Frontiers in Medical Technology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8e823b885bf55fc192d7d1b8f599f2c
https://pubmed.ncbi.nlm.nih.gov/35047913
https://pubmed.ncbi.nlm.nih.gov/35047913