A Jacob/nsmf gene knockout does not protect against acute hypoxia- and NMDA-induced excitotoxic cell death

Autor: Guilherme M. Gomes, Julia Bär, Anna Karpova, Michael R. Kreutz

Publikováno v: Molecular Brain, Vol 16, Iss 1, Pp 1-4 (2023)

Abstract Jacob is a synapto-nuclear messenger protein that encodes and transduces the origin of synaptic and extrasynaptic NMDA receptor signals to the nucleus. The protein assembles a signalosome that differs in case of synaptic or extrasynaptic NMD

Externí odkaz: https://doaj.org/article/f818bb40a99642d297f09ccc23c38f0e

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Visual Disfunction due to the Selective Effect of Glutamate Agonists on Retinal Cells

Autor: Nicolás Cuenca, Ariadna Díaz-Tahoces, Eduardo Fernández, Pedro de la Villa, Santiago Milla-Navarro, Isabel Ortuño-Lizarán, Francisco Germain

Publikováno v: RUA. Repositorio Institucional de la Universidad de Alicante
Universidad de Alicante (UA)
International Journal of Molecular Sciences
Volume 22
Issue 12
International Journal of Molecular Sciences, Vol 22, Iss 6245, p 6245 (2021)

One of the causes of nervous system degeneration is an excess of glutamate released upon several diseases. Glutamate analogs, like N-methyl-DL-aspartate (NMDA) and kainic acid (KA), have been shown to induce experimental retinal neurotoxicity. Previo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5e47292ab8956e180b19f83d44eae81
https://pubmed.ncbi.nlm.nih.gov/34200611

Status Epilepticus Induces Changes in the Expression and Localization of Endogenous Palmitoyl-Protein Thioesterase 1

Autor: J. Suopanki, M. Lintunen, H. Lahtinen, M. Haltia, P. Panula, M. Baumann, J. Tyynelä

Publikováno v: Neurobiology of Disease, Vol 10, Iss 3, Pp 247-257 (2002)

Kainic acid (KA)-induced experimental epilepsy, a model of excitotoxicity, leads to selective neuronal death and synaptic restructuring. We used this model to investigate the effects of neuronal hyperactivation on palmitoyl-protein thioesterase 1 (PP

Externí odkaz: https://doaj.org/article/4c75aea8211b45808730dc05bcfa4431

Climate change and neurodegenerative diseases

Autor: Silvia Maria Masciandaro, Roberto Buizza, Marco Dini, Andrea Diana, Paolo Bongioanni, Gabriella Cavallini, Silvia Corbianco, Renata Del Carratore

Publikováno v: Environmental Research. 201:111511

The climate change induced global warming, and in particular the increased frequency and intensity of heat waves, have been linked to health problems. Among them, scientific works have been reporting an increased incidence of neurological diseases, e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa31a447810581bdaf8229d3cc370493
https://doi.org/10.1016/j.envres.2021.111511