Výsledky vyhledávání - "Excitatory Amino Acid Transporter 2/metabolism"

Genetic deletion of xCT attenuates peripheral and central inflammation and mitigates LPS-induced sickness and depressive-like behavior in mice

Autor: Hideyo Sato, Laura Walrave, Yun Zhou, Ilse Julia Smolders, Sigrid Ottestad-Hansen, Lauren Deneyer, Ann Massie, Thomas Demuyser, Eduard Bentea, Dimitri De Bundel, Niels C. Danbolt, Giulia Albertini, Gamze Ates

Publikováno v: Glia. 66(9)

The communication between the immune and central nervous system (CNS) is affected in many neurological disorders. Peripheral injections of the endotoxin lipopolysaccharide (LPS) are widely used to study this communication: an LPS challenge leads to a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ecb497c0f2dab5a5ef8eb714e543c56
https://pubmed.ncbi.nlm.nih.gov/29693305

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The cystine-glutamate exchanger (xCT, Slc7a11) is expressed in significant concentrations in a subpopulation of astrocytes in the mouse brain

Autor: Ann Massie, Virgine Veronique Follin-Arbelet, Yun Zhou, Sigrid Ottestad-Hansen, Hideyo Sato, Qiu Xiang Hu, Niels C. Danbolt, Eduard Bentea

The cystine-glutamate exchanger (xCT) promotes glutathione synthesis by catalyzing cystine uptake and glutamate release. The released glutamate may modulate normal neural signaling and contribute to excitotoxicity in pathological situations. Uncertai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::955e3945db56a918d95376b04e60f3a2
http://hdl.handle.net/10852/73005

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