Výsledky vyhledávání - "Ewoud N. Speksnijder"

In Vitro, In Vivo Comparison of Cyclosporin A Induced Hepatic Protein Expression Profiles

Autor: Ewoud N. Speksnijder, Freek G. Bouwman, Johan Renes, Jean-Paul Noben, Leo T.M. van der Ven, Anke Van Summeren, Edwin C. M. Mariman, Anne S. Kienhuis, Jos C. S. Kleinjans

Publikováno v: Journal of Clinical Toxicology, 6:299. Omics Publishing Group

To reduce the amount of laboratory animals which are used to analyze hepatotoxic properties of chemicals and drugs, the development of alternative in vitro models is necessary. Ideally these in vitro models reflect the in vivo toxicological response

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d35900f422f037554fdb4999bc63d0db
https://doi.org/10.4172/2161-0495.1000299

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Developmental stage-specific contribution of LGR5+cells to basal and luminal epithelial lineages in the postnatal mammary gland

Autor: Metamia Ciampricotti, David Wei Min Tan, Cheei-Sing Hau, Karin E. de Visser, Nick Barker, Ewa M. Michalak, Ewoud N. Speksnijder, Jos Jonkers, Hans Clevers

Publikováno v: The Journal of Pathology. 228:300-309

The leucine-rich repeat-containing heterotrimeric guanine nucleotide-binding protein-coupled receptor 5 (LGR5) has been identified as a marker of cycling stem cells in several epithelial tissues, including small intestine, colon, stomach and hair fol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d1504aaec0e9ec1b652d7b6c311165f5
https://doi.org/10.1002/path.4096

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Development of metastatic HER2+ breast cancer is independent of the adaptive immune system

Autor: Karin E. de Visser, Cheei-Sing Hau, Kim Vrijland, Metamia Ciampricotti, Tea Pemovska, Katharina Wartha, Ewoud N. Speksnijder, Chris W. Doornebal, Jos Jonkers

Publikováno v: The Journal of Pathology. 224:56-66

The tumour-modulating effects of the endogenous adaptive immune system are rather paradoxical. Whereas some clinical and experimental observations offer compelling evidence for the existence of immunosurveillance, other studies have revealed promotin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cbd5ca9df4376c1350da79c6cd7740e7
https://doi.org/10.1002/path.2837

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Dominant-Negative but not Gain-of-Function Effects of a p53.R270H Mutation in Mouse Epithelium Tissue after DNA Damage

Autor: X. Liu, Jos Jonkers, Rudolf B. Beems, Harry van Steeg, Susan W.P. Wijnhoven, Edwin P. Zwart, Laura D. Attardi, Ewoud N. Speksnijder, Annemieke de Vries, Conny Th. M. vanOostrom, Mirjam M. Schaap, Esther M. Hoogervorst, Tyler Jacks

Publikováno v: Cancer Research. 67:4648-4656

p53 alterations in human tumors often involve missense mutations that may confer dominant-negative or gain-of-function properties. Dominant-negative effects result in inactivation of wild-type p53 protein in heterozygous mutant cells and as such in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db8c7d62f5030e8eb2bf5de83ced58c
https://doi.org/10.1158/0008-5472.can-06-4681

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Mammary gland tumor promotion by chronic administration of IGF1 and the insulin analogue AspB10 in the p53(R270H/+)WAPCre mouse model

Autor: Esmee Koedoot, Bob van de Water, Harry van Steeg, Christine L E Siezen, Ewoud N Speksnijder, Jan Willem van der Laan, Daniela C.F. Salvatori, Bas ter Braak

Publikováno v: Breast cancer research, 17, 14
Breast Cancer Research : BCR
Breast cancer research

Introduction Insulin analogues are structurally modified molecules with altered pharmaco-kinetic and -dynamic properties compared to regular human insulin used by diabetic patients. While these compounds are tested for undesired mitogenic effects, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52a44ef2a76d9f269f14bad03f9ac274
https://doi.org/10.1186/s13058-015-0518-y

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An Xpd mouse model for the combined xeroderma pigmentosum/Cockayne syndrome exhibiting both cancer predisposition and segmental progeria

Autor: Wim Vermeulen, Marcel Volker, Rudolph B. Beems, Wendy Toussaint, Anja Raams, James R. Mitchell, Ewoud N. Speksnijder, Nicolaas G. J. Jaspers, Jaan-Olle Andressoo, Harry van Steeg, Jan H.J. Hoeijmakers, Alan R. Lehmann, Jan de Wit, Deborah Hoogstraten, Chris I. De Zeeuw, Gijsbertus T. J. van der Horst, Judith Jans

Publikováno v: Cancer Cell, 10(2), 121-132. Cell Press

SummaryInborn defects in nucleotide excision DNA repair (NER) can paradoxically result in elevated cancer incidence (xeroderma pigmentosum [XP]) or segmental progeria without cancer predisposition (Cockayne syndrome [CS] and trichothiodystrophy [TTD]

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4d419bd0fc63900ef6d2754f475ec30

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The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/-) and Trp53(-/-) mice

Autor: Annette M, Krais, Ewoud N, Speksnijder, Joost P M, Melis, Radek, Indra, Michaela, Moserova, Roger W, Godschalk, Frederik-J, van Schooten, Albrecht, Seidel, Klaus, Kopka, Heinz H, Schmeiser, Marie, Stiborova, David H, Phillips, Mirjam, Luijten, Volker M, Arlt

Publikováno v: Archives of Toxicology

The tumour suppressor p53 is one of the most important cancer genes. Previous findings have shown that p53 expression can influence DNA adduct formation of the environmental carcinogen benzo[a]pyrene (BaP) in human cells, indicating a role for p53 in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c7e83b0103f49024fcc9d7e6611651b1
https://pubmed.ncbi.nlm.nih.gov/25995008

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