Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Ewoud J. van Hoogdalem"'
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Akademický článek
Ototopical drops containing a novel antibacterial synthetic peptide: Safety and efficacy in adults with chronic suppurative otitis media.
Autor: Nanno F A W Peek, Marja J Nell, Ronald Brand, Thekla Jansen-Werkhoven, Ewoud J van Hoogdalem, Ruud Verrijk, Marcel J Vonk, Amon R Wafelman, A Rob P M Valentijn, Johan H M Frijns, Pieter S Hiemstra, Jan W Drijfhout, Peter H Nibbering, Jan J Grote
Publikováno v: PLoS ONE, Vol 15, Iss 4, p e0231573 (2020)
OBJECTIVE:Chronic suppurative otitis media (CSOM) is a chronic infectious disease with worldwide prevalence that causes hearing loss and decreased quality of life. As current (antibiotic) treatments often unsuccessful and antibiotic resistance is eme
Externí odkaz: https://doaj.org/article/016758d3e2bf487cacaca5ca149296a8
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2
Ototopical drops containing a novel antibacterial synthetic peptide
Autor: Johan H. M. Frijns, Marcel J. Vonk, Amon R. Wafelman, Jan W. Drijfhout, Peter H. Nibbering, R. Verrijk, Ewoud J. van Hoogdalem, Nanno F. A. W. Peek, Thekla Jansen-Werkhoven, Pieter S. Hiemstra, Jan J. Grote, Ronald Brand, A. Rob P. M. Valentijn, Marja J. Nell
Publikováno v: PLoS ONE, 15(4). PUBLIC LIBRARY SCIENCE
PLoS ONE, Vol 15, Iss 4, p e0231573 (2020)
PLoS ONE
Objective Chronic suppurative otitis media (CSOM) is a chronic infectious disease with worldwide prevalence that causes hearing loss and decreased quality of life. As current (antibiotic) treatments often unsuccessful and antibiotic resistance is eme
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b46e37635c0c11d8d947bc5fe8ca5da
https://hdl.handle.net/1887/3182073
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3
Evaluation of proinflammatory cytokines and inflammation markers as biomarkers for the action of thiazolidinediones in Type 2 diabetes mellitus patients and healthy volunteers
Autor: Adam F. Cohen, Margriet Ouwens, Marieke de Kam, Rik C. Schoemaker, Michiel J. B. Kemme, Hans Romijn, Martijn B A van Doorn, Ewoud J. van Hoogdalem, Richard Jones, K. Burggraaf
Publikováno v: British Journal of Clinical Pharmacology. 62:391-402
Aims Thiazolidinediones (TZDs) not only enhance cellular glucose transport but are reported to have potent anti-inflammatory effects. These effects may play an important role in the insulin sensitizing mechanism, and possibly precede the effects on p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9687314a4deca16754f510e05cbc6ee
https://doi.org/10.1111/j.1365-2125.2005.02532.x
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4
In-vitro Metabolism of YM17E, an Inhibitor of Acyl Coenzyme A: Cholesterol Acyltransferase, by Liver Microsomes in Man
Autor: Ewoud J. van Hoogdalem, Saburo Higuchi, Taisuke Uchida, Takashi Watanabe
Publikováno v: Journal of Pharmacy and Pharmacology. 48:1049-1056
Because YM17E (1,3-bis[[1-cycloheptyl-3-(p-dimethylaminophenyl)ureido]methyl]benzene dihydrochloride) inhibits acyl coenzyme A:cholesterol acyltransferase (ACAT) it has potential application in the treatment of hypercholesterolaemia. In man and anima
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e781ce9f67ad37c1d93f58a174ac23e
https://doi.org/10.1111/j.2042-7158.1996.tb05898.x
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6
Novel controlled-release Lemna-derived IFN-alpha2b (Locteron): pharmacokinetics, pharmacodynamics, and tolerability in a phase I clinical trial
Autor: Leo G.J. de Leede, Anne C. Bechet, Ewoud J. van Hoogdalem, John Elliott Humphries, Ruud Verrijk, David Gelvin. Spencer
Publikováno v: Journal of interferoncytokine research : the official journal of the International Society for Interferon and Cytokine Research. 28(2)
Locteron, a newly developed controlled-release formulation of Lemna-derived free (unpegylated) recombinant interferon-alpha2b (IFN-alpha2b, Biolex Therapeutics, Pittsboro, NC) in poly(ether-ester) microspheres (PolyActive, OctoPlus N.V., Leiden, the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abcfdc3962a6b543695a91d84eed211a
https://pubmed.ncbi.nlm.nih.gov/18279106
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7
Topical Effects of Absorption Enhancing Agents on the Rectal Mucosa of Rats in Vivo
Autor: Albertus G. de Boer, Douwe D. Breimer, Christl Vermeij-Kerrs, Ewoud J. van Hoogdalem
Publikováno v: Journal of Pharmaceutical Sciences. 79:866-870
In the present study, attempts have been made to assess the effects of cefoxitin formulations with various absorption promoters on mucosal integrity after rectal delivery in rats. Observations were made at 2 and 24 h following drug administration. On
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::725ef4c9d01cffd6967ac57f85c7aa56
https://doi.org/10.1002/jps.2600791004
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8
Disposition of the selective alpha1A-adrenoceptor antagonist tamsulosin in humans: comparison with data from interspecies scaling
Autor: Ewoud J. van Hoogdalem, Saburo Higuchi, Yoshiaki Soeishi, Hiroshi Matsushima
Publikováno v: Journal of pharmaceutical sciences. 86(10)
Tamsulosin-HCl is an alpha1A-adrenoceptor antagonist that is mainly eliminated by metabolism in animals and humans and is highly bound to alpha1-acid glycoprotein in blood plasma. The disposition of the compound (0.4 mg as modified-release granules i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::924c8a5fd6bb178e5ea21cf1970dafea
https://pubmed.ncbi.nlm.nih.gov/9344174
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