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A point-prevalence study on community and inpatient Clostridioides difficile infections (CDI): results from Combatting Bacterial Resistance in Europe CDI (COMBACTE-CDI), July to November 2018

Autor: Viprey, VF, Davis, GL, Benson, AD, Ewin, D, Spittal, W, Vernon, JJ, Rupnik, M, Banz, A, Allantaz, F, Cleuziat, P, the COMBACTE-CDI National Coordinators, Wilcox, MH, Davies, KA, the COMBACTE-CDI consortium

Background There is a paucity of data on community-based Clostridioides difficile infection (CDI) and how these compare with inpatient CDI. Aim To compare data on the populations with CDI in hospitals vs the community across 12 European countries. Me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::d0a1c168f0c0ab88404729b6916c2730
https://eprints.whiterose.ac.uk/188700/1/eurosurv-27-26-4.pdf

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From the hospital toilet to the ward: A pilot study on microbe dispersal to multiple hospital surfaces following hand drying using a jet air dryer versus paper towels

Autor: Moura, IB, Ewin, D, Wilcox, MH

Using a bacteriophage to represent microbial contamination, we investigated virus transmission to the hospital environment following hand drying. The use of paper towels resulted in lower rates of virus contamination on hands and clothing compared wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::6c397ed8d0d920c37619350913b67d0b
https://eprints.whiterose.ac.uk/173096/1/from-the-hospital-toilet-to-the-ward-a-pilot-study-on-microbe-dispersal-to-multiple-hospital-surfaces-following-hand-drying-using-a-jet-air-dryer-versus-paper-towels.pdf

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The use of first-generation cephalosporin antibiotics, cefalexin and cefradine, is not associated with induction of simulated Clostridioides difficile infection

Autor: Buckley, AM, Moura, IB, Altringham, J, Ewin, D, Clark, E, Bentley, K, Wilkinson, V, Spittal, W, Davis, G, Wilcox, MH

Objectives The use of broad-spectrum cephalosporins is associated with induction of Clostridioides difficile infection (CDI). Recent knowledge on the importance of the healthy microbiota in preventing pathogen colonization/outgrowth highlights the ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::3371d4d97be257f6b598237eff661fba
https://eprints.whiterose.ac.uk/180504/1/Proofs.pdf

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Eravacycline, a novel tetracycline derivative, does not induce Clostridioides difficile infection in an in vitro human gut model

Autor: Buckley, AM, Altringham, J, Clark, E, Bently, K, Spittal, W, Ewin, D, Wilkinson, V, Davis, G, Moura, IB, Wilcox, MH

Objectives: The approval of new antibiotics is essential to combat infections caused by antimicrobial-resistant pathogens; however, such agents should be tested to determine their effect on the resident microbiota and propensity to select for opportu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::a459e9a640f30c980fabc76118f5cede

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Omadacycline gut microbiome exposure does not induce Clostridium difficile proliferation or toxin production in a model that simulates the proximal, medial and distal human colon

Autor: Moura, IB, Buckley, AM, Ewin, D, Shearman, S, Clark, E, Wilcox, MH, Chilton, CH

A clinically reflective model of the human colon was used to investigate the effects of the broad-spectrum antibiotic omadacycline on the gut microbiome, and subsequent potential to induce simulated Clostridium difficile infection (CDI). Triple stage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::e20d1e044449fa2c2c23eab8da34e3a9

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224 Profiling the effects of acne therapeutics, including the novel narrow-spectrum antibiotic sarecycline, on the human microbiota

Autor: Moura, I., Spittal, W., Clark, E., Ewin, D., Altringham, J., Fumero, E., Grada, A., Wilcox, M., Buckley, A.

Publikováno v: In Journal of Investigative Dermatology October 2021 141(10) Supplement:S187-S187

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Efficacy of vancomycin extended dosing regimens for treatment of simulated Clostridium difficile infection (CDI) within an in vitro human gut model

Autor: Crowther, GS, Chilton, CH, Longshaw, C, Todhunter, SL, Ewin, D, Vernon, J, Karas, A, Wilcox, MH

Objectives: Effects of two vancomycin extended-dosing regimens on microbiota populations within an in-vitro gut model of simulated C. difficile infection (CDI) were evaluated. Methods: Two chemostat gut models were inoculated with faecal emulsion, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::99c4732f7c6eaccd050836c50bfb151d

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