Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Ewen D D, Calder"'
Corrigendum: HPLC for at-line reaction monitoring and purification improves yield and purity of tRNA
Autor:
Polona Megušar, Ewen D. D. Calder, Tina Vodopivec Seravalli, Sergeja Lebar, Louise J. Walport, Rok Sekirnik
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Externí odkaz:
https://doaj.org/article/5162f5b8cb7b4c169967c77223525909
Autor:
Polona Megušar, Ewen D. D. Calder, Tina Vodopivec Seravalli, Sergeja Lebar, Louise J. Walport, Rok Sekirnik
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Engineered transfer RNA is an emerging therapeutic modality, particularly suited to treatment of diseases caused by genetic disorders based on premature termination codons, frameshifts, or missense mutations. It is also extensively used in reprogramm
Externí odkaz:
https://doaj.org/article/779c136fa8384102820cf3811c0f1c73
Autor:
James Rowley, Dhira Joshi, M. Teresa Bertran, Louise J. Walport, Ewen D. D. Calder, Yuteng Wu
Publikováno v:
Chemmedchem
The major obstacle in applying peptides to intracellular targets is their low inherent cell permeability. Standard approaches to attach a fluorophore (e. g. FITC, TAMRA) can change the physicochemical properties of the parent peptide and influence th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e79aa3ba24e391afef57d179544090b
http://hdl.handle.net/10044/1/90277
http://hdl.handle.net/10044/1/90277
Publikováno v:
RSC Chemical Biology
Combining different compound classes gives molecular hybrids that can offer access to novel chemical space and unique properties. Peptides provide ideal starting points for such molecular hybrids, which can be easily modified with a variety of molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caa20a5d3ef09859343320a9131ac2de
http://hdl.handle.net/10044/1/85373
http://hdl.handle.net/10044/1/85373
Autor:
Ester M. Hammond, Stuart J. Conway, Lisa K. Folkes, Deborah Sneddon, Ewen D. D. Calder, Anna Skwarska, Ishna N. Mistry
Hypoxia (lower than normal oxygen) is a characteristic of most solid tumours that results in poor cancer patient prognosis. The difference in cellular environment between normoxia (21% oxygen) or physoxia (4–7.5% oxygen) and hypoxia (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16fe6169db43db30e8343400c8ecf39b
http://hdl.handle.net/10044/1/79101
http://hdl.handle.net/10044/1/79101
Autor:
Hannah Bolland, Maria L. Odyniec, Lisa K. Folkes, Jennifer L. Martin, Stuart J. Conway, Ishna N. Mistry, Deborah Sneddon, Anna Skwarska, Ester M. Hammond, Ewen D. D. Calder
Publikováno v:
Cell Chemical Biology. 28:1258-1270.e13
Tumor hypoxia is associated with therapy resistance and poor patient prognosis. Hypoxia-activated prodrugs, designed to selectively target hypoxic cells while sparing normal tissue, represent a promising treatment strategy. We report the pre-clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b21df8b7441c78233e3659c56efa467
https://doi.org/10.1016/j.chembiol.2021.04.004
https://doi.org/10.1016/j.chembiol.2021.04.004
Autor:
Ewen D. D. Calder, Anna Skwarska, Ishna N. Mistry, Deborah Sneddon, Stuart Conway, Ester M. Hammond
Hypoxia (lower than normal oxygen) is a characteristic of most solid tumours that results in poor cancer patient prognosis. The difference in cellular environment between normoxia (21% oxygen) or physoxia (4.5-7% oxygen) and hypoxia (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b775f586d4b458a551dff8539a7c34
https://doi.org/10.26434/chemrxiv.9963503
https://doi.org/10.26434/chemrxiv.9963503
Publikováno v:
The Journal of organic chemistry. 82(21)
A one-pot catalytic enantioselective allylboration/Mizoroki-Heck reaction of 2-bromoaryl ketones has been developed for the asymmetric synthesis of 3-methyleneindanes bearing a tertiary alcohol center. Brønsted acid-catalyzed allylboration with a ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::832f286ea5e8db7e7d84035fed3d8fac
https://pubmed.ncbi.nlm.nih.gov/28985675
https://pubmed.ncbi.nlm.nih.gov/28985675
Publikováno v:
International journal of radiation oncology, biology, physics. 98(5)
With the increasing incidence of cancer worldwide, the need for specific, effective therapies is ever more urgent. One example of targeted cancer therapeutics is hypoxia-activated prodrugs (HAPs), also known as bioreductive prodrugs. These prodrugs a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3c14d36e3f11a8b08c2b34064070bbf
https://pubmed.ncbi.nlm.nih.gov/28721903
https://pubmed.ncbi.nlm.nih.gov/28721903
Publikováno v:
Chemistry (Weinheim an Der Bergstrasse, Germany)
A mild, efficient and regioselective method for para‐amination of activated arenes has been developed through a combination of iron and copper catalysis. A diverse range of products were obtained from an operationally simple one‐pot, two‐step p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efd780dbf56d0426336e41a430eacc94
http://hdl.handle.net/10044/1/78634
http://hdl.handle.net/10044/1/78634